New Adeno-Associated Virus (AAV) Variants and Uses Thereof for Gene Therapy

ABSTRACT

Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. The aimed of the inventors was to characterize the natural history of AAV infection in the liver. Viral DNA was thus quantified in tumor and non-tumor liver tissues of 1461 patients. Presence of episomal form and viral mRNA expression were analyzed using a DNAse/TaqMan based assay and quantitative RT-PCR. In silico analyses using viral capture data explored viral variants and new clonal insertions. AAV DNA was detected in 21% of the patients equally distributed in 2 major viral subtypes: one similar to AAV2, the other hybrid between AAV2 and AAV13 sequences. Thus the inventors provided an integrated analysis of the wild type AAV infection in the liver with the identification of viral genotypes, molecular forms, helper virus relationship and viral integrations. These findings are important to understand wild type AAV biology and particularly relevant considering the large usage of AAV vector in liver-targeted gene therapy. Thus, the present invention relates to new adeno-associated virus (AAV) variants and uses thereof for gene therapy.

FIELD OF THE INVENTION

The present invention relates to new adeno-associated virus (AAV) variants and uses thereof for gene therapy.

BACKGROUND OF THE INVENTION

Adeno-associated virus (AAV) is a small non-enveloped DNA virus composed by an icosahedral capsid that contains a 4.7 kb linear single-stranded genome.^(1, 2) AAV genome codes for non-structural proteins (Rep78, 68, 52 and 40), capsid proteins (VP1, VP2, VP3) and the assembly-activating protein (AAP).^(3, 4) At the extremities, inverse tandem repeats (ITR) are important for the integration in host genomes.^(5, 6) AAV is a defective virus requiring the presence of a helper virus for an active infection, otherwise it establishes a latent infection through integration into host genome or persistence as circular episomal form.⁷⁻⁹ AAV seroprevalence showed that the infection is endemic in human populations (35-80%) starting during childhood.¹⁰⁻¹² Twelve distinct serotypes and more than 100 natural variants have been identified, among which AAV2 is the most frequent type in human.¹³⁻¹⁶

This small virus has attracted the attention of the gene therapy field because of the lack of identifiable associated disease and the remarkable ability of recombinant AAV (rAAV) vectors to transduce dividing and non-dividing cells with high efficiency, long-term transgene expression, low immunogenicity and specific tissue tropism.¹⁷ Although AAV discovery was performed in 1965, many questions regarding AAV infection remain unanswered.^(2, 18) It is well known that the vector predominantly persist in the nucleus as episomal form with sustained RNA expression raising question about the potential presence of episomal AAV in wild type infection.⁸ Several helper viruses have been identified but their precise association with wild type liver AAV infection remains unclear. Few data on the specific AAV genotypes in the population and on the frequency of AAV persistence after first infection are available.¹⁹

SUMMARY OF THE INVENTION

As defined by the claims, the present invention relates to new adeno-associated virus (AAV) variants and uses thereof for gene therapy.

DETAILED DESCRIPTION OF THE INVENTION

Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed in normal liver. The aim of the inventors was to characterize the natural history of AAV infection in the liver. Viral DNA was thus quantified in tumor and non-tumor liver tissues of 1461 patients. Presence of episomal form and viral mRNA expression were analyzed using a DNAse/TaqMan based assay and quantitative RT-PCR. In silico analyses of viral capture data identified viral variants and new clonal insertions. AAV DNA was detected in 21% of the patients equally distributed in 2 major viral subtypes: one similar to AAV2, the other hybrid between AAV2 and AAV13 sequences. Thus, the inventors provided an integrated analysis of the wild type AAV infection in the liver with the identification of viral genotypes, molecular forms, helper virus relationship and viral integrations. These findings are important to understand wild type AAV biology. The data are particularly relevant considering the therapeutic potential of this new AAV variants in liver-targeted gene therapy.

Main Definitions

As used herein, the term “polynucleotide” or “nucleic acid” refers to a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. Thus, this term includes, but is not limited to, single-, double- or multi-stranded DNA or RNA, genomic DNA, cDNA, DNA-RNA hybrids, or a polymer comprising purine and pyrimidine bases, or other natural, chemically or biochemically modified, non-natural, or derivatized nucleotide bases. The backbone of the polynucleotide can comprise sugars and phosphate groups (as may typically be found in RNA or DNA), or modified or substituted sugars or phosphate groups. Alternatively, the backbone of the polynucleotide can comprise a polymer of synthetic subunits such as phosphoramidates and thus can be an oligodeoxynucleoside phosphoramidate (P—NH2) or a mixed phosphoramidate-phosphodiester oligomer. In addition, a double-stranded polynucleotide can be obtained from the single stranded polynucleotide product of chemical synthesis either by synthesizing the complementary strand and annealing the strands under appropriate conditions, or by synthesizing the complementary strand de novo using a DNA polymerase with an appropriate primer.

As used herein, the terms “polypeptide” and “protein” are used interchangeably to refer to a polymer of amino acid residues, and are not limited to a minimum length. Such polymers of amino acid residues may contain natural or non-natural amino acid residues, and include, but are not limited to, peptides, oligopeptides, dimers, trimers, and multimers of amino acid residues. Both full-length proteins and fragments thereof are encompassed by the definition. The terms also include post-expression modifications of the polypeptide, for example, glycosylation, sialylation, acetylation, phosphorylation, and the like. Furthermore, for purposes of the present invention, a “polypeptide” refers to a protein which includes modifications, such as deletions, additions, and substitutions (generally conservative in nature), to the native sequence, as long as the protein maintains the desired activity. These modifications may be deliberate, as through site-directed mutagenesis, or may be accidental, such as through mutations of hosts which produce the proteins or errors due to PCR amplification.

As used herein, “expression” refers to the process by which a polynucleotide is transcribed from a DNA template (such as into and mRNA or other RNA transcript) and/or the process by which a transcribed mRNA is subsequently translated into peptides, polypeptides, or proteins. Transcripts and encoded polypeptides may be collectively referred to as “gene product.”

As used herein the term “wild type” or “native” is a term of the art understood by skilled persons and means the typical form of an organism, strain, gene or characteristic as it occurs in nature as distinguished from mutant forms.

As used herein, the term “mutation” has its general meaning in the art and refers to a substitution, deletion or insertion. In particular, the term “substitution” means that a specific amino acid residue at a specific position is removed and another amino acid residue is inserted into the same position.

As used herein, the term “variant” refers to a first composition (e.g., a first molecule), that is related to a second composition (e.g., a second molecule, also termed a “parent” molecule). The variant molecule can be derived from, isolated from, based on or homologous to the parent molecule. A variant molecule can have entire sequence identity with the original parent molecule, or alternatively, can have less than 100% sequence identity with the parent molecule. For example, a variant of a sequence can be a second sequence that is at least 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94; 95; 96; 97; 98; 99; 100% identical in sequence compared to the original sequence. Sequence identity is frequently measured in terms of percentage identity (or similarity or homology); the higher the percentage, the more similar are the two sequences. Methods of alignment of sequences for comparison are well known in the art. Various programs and alignment algorithms are described in: Smith and Waterman, Adv. Appl. Math., 2:482, 1981; Needleman and Wunsch, J. Mol. Biol., 48:443, 1970; Pearson and Lipman, Proc. Natl. Acad. Sci. U.S.A., 85:2444, 1988; Higgins and Sharp, Gene, 73:237-244, 1988; Higgins and Sharp, CABIOS, 5:151-153, 1989; Corpet et al. Nuc. Acids Res., 16:10881-10890, 1988; Huang et al., Comp. Appls Biosci., 8:155-165, 1992; and Pearson et al., Meth. Mol. Biol., 24:307-31, 1994). Altschul et al., Nat. Genet., 6:119-129, 1994, presents a detailed consideration of sequence alignment methods and homology calculations. By way of example, the alignment tools ALIGN (Myers and Miller, CABIOS 4:11-17, 1989) or LFASTA (Pearson and Lipman, 1988) may be used to perform sequence comparisons (Internet Program® 1996, W. R. Pearson and the University of Virginia, fasta20u63 version 2.0u63, release date December 1996). ALIGN compares entire sequences against one another, while LFASTA compares regions of local similarity. These alignment tools and their respective tutorials are available on the Internet at the NCSA Website, for instance. Alternatively, for comparisons of amino acid sequences of greater than about 30 amino acids, the Blast 2 sequences function can be employed using the default BLOSUM62 matrix set to default parameters, (gap existence cost of 11, and a per residue gap cost of 1). When aligning short peptides (fewer than around 30 amino acids), the alignment should be performed using the Blast 2 sequences function, employing the PAM30 matrix set to default parameters (open gap 9, extension gap 1 penalties). The BLAST sequence comparison system is available, for instance, from the NCBI web site; see also Altschul et al., J. Mol. Biol., 215:403-410, 1990; Gish. & States, Nature Genet., 3:266-272, 1993; Madden et al. Meth. Enzymol., 266:131-141, 1996; Altschul et al., Nucleic Acids Res., 25:3389-3402, 1997; and Zhang & Madden, Genome Res., 7:649-656, 1997.

As used herein, the term “adeno-associated virus” or “AAV” has its general meaning in the art and refers to a Dependoparvovirus within the Parvoviridae genus of viruses. The term can refer to an AAV derived from a naturally occurring “wild-type” virus, or an AAV derived from a rAAV genome packaged into a capsid derived from capsid proteins encoded by a naturally occurring cap gene. The term “AAV” includes AAV type 1 (AAV-1), AAV type 2 (AAV-2), AAV type 3 (AAV-3), AAV type 4 (AAV-4), AAV type 5 (AAV-5), AAV type 6 (AAV-6), AAV type 7 (AAV-7), AAV type 8 (AAV-8), avian AAV, bovine AAV, canine AAV, porcine AAV, equine AAV, primate AAV, non-primate AAV, and ovine AAV. “Primate AAV” refers to AAV that infect primates, “non-primate AAV” refers to AAV that infect non-primate mammals, “bovine AAV” refers to AAV that infect bovine mammals, etc. The genomic sequences of various serotypes of AAV, as well as the sequences of the native inverted terminal repeats (ITRs), Rep proteins, and capsid subunits are known in the art. Such sequences may be found in the literature or in public databases such as GenBank. See, e.g., GenBank Accession Numbers NC-002077 (AAV-1), AF063497 (AAV-1), NC-001401 (AAV-2), AF043303 (AAV-2), NC-001729 (AAV-3), NC-001829 (AAV-4), U89790 (AAV-4), NC-006152 (AAV-5), AF513851 (AAV-7), AF513852 (AAV-8), and NC-006261 (AAV-8); the disclosures of which are incorporated by reference herein for teaching AAV nucleic acid and amino acid sequences. See also, e.g., Srivistava et al. (1983) J. Virology 45:555; Chiorini et al. (1998) J. Virology 71:6823; Chiorini et al. (1999) J. Virology 73:1309; Bantel-Schaal et al. (1999) J. Virology 73:939; Xiao et al. (1999) J. Virology 73:3994; Muramatsu et al. (1996) Virology 221:208; Shade et al. (1986) J. Virol. 58:921; Gao et al. (2002) Proc. Nat. Acad. Sci. USA 99:11854; Moris et al. (2004) Virology 33:375-383; international patent publications WO 00/28061, WO 99/61601, WO 98/11244; and U.S. Pat. No. 6,156,303. The complete genome of AAV2 is represented by the reference sequence as set forth in SEQ ID NO:1.

SEQ ID NO: 1 >NCBI Reference Sequence: NC_001401.2 1 ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 61 cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 121 gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag 181 ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat 241 gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga 301 ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg 361 accttgacga gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg 421 aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga 481 ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc 541 cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc 601 tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg 661 aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg 721 tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc 781 ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac 841 agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga 901 cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc 961 cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca 1021 aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca 1081 atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta 1141 tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt 1201 ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt 1261 ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg 1321 ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct 1381 acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg 1441 tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc 1501 tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga 1561 ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga 1621 ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc 1681 tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa 1741 aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa 1801 gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc 1861 agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat 1921 gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga 1981 atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg 2041 tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc 2101 atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt 2161 tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat 2221 cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa 2281 cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg 2341 cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac 2401 gaggcagacg ccgcggccct cgagcacgac aaagcctacg accggcagct cgacagcgga 2461 gacaacccgt acctcaagta caaccacgcc gacgcggagt ttcaggagcg ccttaaagaa 2521 gatacgtctt ttgggggcaa cctcggacga gcagtcttcc aggcgaaaaa gagggttctt 2581 gaacctctgg gcctggttga ggaacctgtt aagacggctc cgggaaaaaa gaggccggta 2641 gagcactctc ctgtggagcc agactcctcc tcgggaaccg gaaaggcggg ccagcagcct 2701 gcaagaaaaa gattgaattt tggtcagact ggagacgcag actcagtacc tgacccccag 2761 cctctcggac agccaccagc agccccctct ggtctgggaa ctaatacgat ggctacaggc 2821 agtggcgcac caatggcaga caataacgag ggcgccgacg gagtgggtaa ttcctcggga 2881 aattggcatt gcgattccac atggatgggc gacagagtca tcaccaccag cacccgaacc 2941 tgggccctgc ccacctacaa caaccacctc tacaaacaaa tttccagcca atcaggagcc 3001 tcgaacgaca atcactactt tggctacagc accccttggg ggtattttga cttcaacaga 3061 ttccactgcc acttttcacc acgtgactgg caaagactca tcaacaacaa ctggggattc 3121 cgacccaaga gactcaactt caagctcttt aacattcaag tcaaagaggt cacgcagaat 3181 gacggtacga cgacgattgc caataacctt accagcacgg ttcaggtgtt tactgactcg 3241 gagtaccagc tcccgtacgt cctcggctcg gcgcatcaag gatgcctccc gccgttccca 3301 gcagacgtct tcatggtgcc acagtatgga tacctcaccc tgaacaacgg gagtcaggca 3361 gtaggacgct cttcatttta ctgcctggag tactttcctt ctcagatgct gcgtaccgga 3421 aacaacttta ccttcagcta cacttttgag gacgttcctt tccacagcag ctacgctcac 3481 agccagagtc tggaccgtct catgaatcct ctcatcgacc agtacctgta ttacttgagc 3541 agaacaaaca ctccaagtgg aaccaccacg cagtcaaggc ttcagttttc tcaggccgga 3601 gcgagtgaca ttcgggacca gtctaggaac tggcttcctg gaccctgtta ccgccagcag 3661 cgagtatcaa agacatctgc ggataacaac aacagtgaat actcgtggac tggagctacc 3721 aagtaccacc tcaatggcag agactctctg gtgaatccgg gcccggccat ggcaagccac 3781 aaggacgatg aagaaaagtt ttttcctcag agcggggttc tcatctttgg gaagcaaggc 3841 tcagagaaaa caaatgtgga cattgaaaag gtcatgatta cagacgaaga ggaaatcagg 3901 acaaccaatc ccgtggctac ggagcagtat ggttctgtat ctaccaacct ccagagaggc 3961 aacagacaag cagctaccgc agatgtcaac acacaaggcg ttcttccagg catggtctgg 4021 caggacagag atgtgtacct tcaggggccc atctgggcaa agattccaca cacggacgga 4081 cattttcacc cctctcccct catgggtgga ttcggactta aacaccctcc tccacagatt 4141 ctcatcaaga acaccccggt acctgcgaat ccttcgacca ccttcagtgc ggcaaagttt 4201 gcttccttca tcacacagta ctccacggga caggtcagcg tggagatcga gtgggagctg 4261 cagaaggaaa acagcaaacg ctggaatccc gaaattcagt acacttccaa ctacaacaag 4321 tctgttaatg tggactttac tgtggacact aatggcgtgt attcagagcc tcgccccatt 4381 ggcaccagat acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc 4441 gtttcagttg aactttggtc tctgcgtatt tctttcttat ctagtttcca tggctacgta 4501 gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc 4561 actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc 4621 ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa

As used herein, the term “cap gene” refers to the polynucleotide that encode capsid proteins that form, or contribute to the formation of, the capsid, or protein shell, of the virus. In the case of AAV2, the capsid protein may be VP1, VP2, or VP3. For other parvoviruses, the names and numbers of the capsid proteins can differ. The VP1 capsid protein of AAV2 is represented by the reference amino acid sequence as set forth in SEQ ID NO:2. The VP2 capsid protein of AAV2 is represented by the amino acid sequence that ranges from the amino acid residue at position 138 to the last amino acid residue in SEQ ID NO:2. The VP3 capsid protein of AAV2 is represented by the amino acid sequence that ranges from the amino acid residue at position 203 to the last amino acid residue in SEQ ID NO:2.

SED ID NO: 2 >sp|P03135|CAPSD_AAV2S Capsid protein VP1 OS = Adeno-associated virus 2 (isolate Srivastava/ 1982) OX = 648242 GN = VP1 PE = 1 SV = 2 MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGY KYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEF QERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSP VEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGT NTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALP TYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLI NNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQL PYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNT PSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEY SWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKT NVDIEKVMITDEEEIRTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGV LPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKN TPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQY TSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL

As used herein, the term “rep gene” refers to the nucleic acid sequences that encode the non-structural proteins (rep78, rep68, rep52 and rep40) required for the replication and production of virus.

As used herein, the term “packaging” refers to a series of intracellular events that result in the assembly and encapsidation of an AAV virus.

A “helper virus” for AAV refers to a virus that allows AAV (e.g. wild-type AAV) to be replicated and packaged by a mammalian cell. A variety of such helper viruses for AAV are known in the art, including adenoviruses, herpesviruses and poxviruses such as vaccinia. The adenoviruses encompass a number of different subgroups, although Adenovirus type 5 of subgroup C is most commonly used. Numerous adenoviruses of human, non-human mammalian and avian origin are known and available from depositories such as the ATCC. Viruses of the herpes family include, for example, herpes simplex viruses (HSV) and Epstein-Barr viruses (EBV), as well as cytomegaloviruses (CMV) and pseudorabies viruses (PRV); which are also available from depositories such as ATCC. “Helper virus function(s)” refers to function(s) encoded in a helper virus genome which allow AAV replication and packaging (in conjunction with other requirements for replication and packaging described herein). As described herein, “helper virus function” may be provided in a number of ways, including by providing helper virus or providing, for example, polynucleotide sequences encoding the requisite function(s) to a producer cell in trans. For example, a plasmid or other expression vector comprising nucleotide sequences encoding one or more adenoviral proteins is transfected into a producer cell along with nucleotidic sequences enconding for the AAV rep and cap genes and a transgene expression cassette flanked by two ITRs to produce a rAAV

As used herein, the term “virus viral particle” is one that comprises a competently assembled viral capsid and is capable of delivering a polynucleotide component into a cell for which the viral species is tropic. The term does not necessarily imply any replication capacity of the virus. Assays for counting infectious viral particles are described elsewhere in this disclosure and in the art. Viral infectivity can be expressed as the ratio of infectious viral particles to total viral particles. Methods of determining the ratio of infectious viral particle to total viral particle are known in the art. See, e.g., Grainger et al. (2005) Mol. Ther. 11:S337 (describing a TCID50 infectious titer assay); and Zolotukhin et al. (1999) Gene Ther. 6:973. See also the Examples.

As used herein, the term “transgene” refers to a polynucleotide that is introduced into a cell and is capable of being transcribed into RNA and optionally, translated and/or expressed under appropriate conditions. In aspects, it confers a desired property to a cell into which it is introduced, or otherwise leads to a desired therapeutic outcome. In another aspect, it may be transcribed into a molecule that mediates RNA interference, such as miRNA, siRNA, or shRNA.

As used herein, the term “control element” or “control sequence” is a nucleotide sequence involved in an interaction of molecules that contributes to the functional regulation of a polynucleotide, including replication, duplication, transcription, splicing, translation, or degradation of the polynucleotide. The regulation may affect the frequency, speed, or specificity of the process, and may be enhancing or inhibitory in nature. Control elements known in the art include, for example, transcriptional regulatory sequences such as promoters and enhancers. A promoter is a DNA region capable under certain conditions of binding RNA polymerase and initiating transcription of a coding region usually located downstream (in the 3′ direction) from the promoter.

As used herein, the term “operatively linked” or “operably linked” refers to a juxtaposition of genetic elements, wherein the elements are in a relationship permitting them to operate in the expected manner. For instance, a promoter is operatively linked to a coding region if the promoter helps initiate transcription of the coding sequence. There may be intervening residues between the promoter and coding region so long as this functional relationship is maintained.

As used herein, the term “heterologous” means derived from a genotypically distinct entity from that of the rest of the entity to which it is being compared. For example, a polynucleotide introduced by genetic engineering techniques into a plasmid or vector derived from a different species is a heterologous polynucleotide. A promoter removed from its native coding sequence and operatively linked to a coding sequence with which it is not naturally found linked is a heterologous promoter. Thus, for example, an rAAV that includes a heterologous nucleic acid encoding a heterologous gene product is an rAAV that includes a nucleic acid not normally included in a naturally-occurring, wild-type AAV, and the encoded heterologous gene product is a gene product not normally encoded by a naturally-occurring, wild-type AAV.

As used herein, the term “isolated” when referred to a plasmid, nucleic acid, vector, virus, virion, host cell, or other substance refers to a preparation of the substance devoid of at least some of the other components that may also be present where the substance or a similar substance naturally occurs or is initially prepared from. Thus, for example, an isolated substance may be prepared by using a purification technique to enrich it from a source mixture. Enrichment can be measured on an absolute basis, such as weight per volume of solution, or it can be measured in relation to a second, potentially interfering substance present in the source mixture. Increasing enrichments of the embodiments of this disclosure are increasingly more isolated. An isolated plasmid, nucleic acid, vector, virus, host cell, or other substance is in some embodiments purified, e.g., from about 80% to about 90% pure, at least about 90% pure, at least about 95% pure, at least about 98% pure, or at least about 99%, or more, pure.

The term “Pharmaceutically” or “pharmaceutically acceptable” refer to molecular entities and compositions that do not produce an adverse, allergic or other untoward reaction when administered to a mammal, especially a human, as appropriate.

By a “therapeutically effective amount” is meant a sufficient amount of the rAAV of the present invention to treat the disease at a reasonable benefit/risk ratio. It will be understood that the total daily usage of the rAAV of the present invention will be decided by the attending physician within the scope of sound medical judgment. The specific therapeutically effective dose level for any particular patient will depend upon a variety of factors including the age, body weight, general health, sex and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidental with the specific polypeptide employed; and like factors well known in the medical arts. For example, it is well known within the skill of the art to start doses of the compound at levels lower than those required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved. Thus, the doses of vectors may be adapted depending on the disease condition, the subject (for example, according to his weight, metabolism, etc.), the treatment schedule, etc. A preferred effective dose within the context of this invention is a dose allowing an optimal transduction of the cone photoreceptors. Typically, from 10⁸ to 10¹⁰ viral genomes (vg) are administered per dose in mice. Typically, the doses of AAV to be administered in humans may range from 10⁹ to 10¹² vg.

Variant AAV2 Capsid Protein:

An object of the present invention relates to a variant VP1 capsid protein that consists of the amino acid sequence as set forth in SEQ ID NO:2 comprising at least one mutation of the table 1.

An object of the present invention relates to a variant VP2 capsid protein that consists of the amino acid sequence that ranges from the amino acid at position 138 to the last amino acid in SEQ ID NO:2 comprising at least one mutation of the table 1.

An object of the present invention relates to a variant VP3 capsid protein that consists of the amino acid sequence that ranges from the amino acid at position 203 to the last amino acid in SEQ ID NO:2 comprising at least one mutation of the table 1.

TABLE 1 List of the mutations present in the capsid sequences Nucleotide Change (coordinates on NC_001401) Protein Change Samples with variant 2236G > C 12E > Q #2112 2237A > G 12E > G #1010 2238G > A #2112 2241C > G 13D > E #1010 2241C > A 13D > E #2112 2243_2244delinsAC 14T > N #1024 #2112 2244T > C #1010 2246T > C 15L > P #985 2247C > A #2112 2248_2249delinsAG #1024 2249C > T 16S > F #2112 2251G > C 17E > Q #1010 2251_2253delinsTTC 17E > F #2112 2252A > C 17E > A #985 2255_2256delinsAT 18G > D #2112 2259A > T #1024 2260A > C #1024 #2112 2262A > C #1024 2262A > T 20R > S #985 2263C > G 21Q > E #1024 2272_2275delinsGCTT 24K > A #1024 2277C > G #1024 2277C > T #442 2286_2287delinsAG 29P > A #1024 2289A > C #1024 2292A > T #1024 2292A > G #668 2294C > A 31P > Q #1024 2295A > G #M258 2298A > C #1024 2302C > T 34P > S #1602 2302_2313delinsGCAAATCAACAA 34_37delinsANQQ #1024 2316T > C #3013 #3511 #777 2317A > C 39K > Q #1024 #1273 #129 #1534 #2102 #2112 2319G > A #1024 #767 2323G > A 41D > N #1024 #2112 #2806 #3086 2326_2329delinsGCTC 42S > A #1024 2326A > G 42S > G #1260 2327G > A 42S > N #1449 #668 2328C > T #3013 2346T > G #1024 2349G > T #1024 2355G > A #1024 2361C > T #1024 #2206 2367C > T #508 2368_2369delinsGG 56F > G #1024 2385G > A #1602 #1704 #2102 #3013 #777 2388A > G #1024 #1343 #1449 #2040 #3765 #387 #471 #473 2391G > A #1010 2402AG > CA 67E > A #1024 2412C > G #1024 2419C > A 73L > I #508 2424G > A #1010 #2497 #2557 #2806 #3013 2433A > G #1010 #1017 #1020 #1024 #1158 #1260 #1273 #1286 #1343 #1350 #1449 #1534 #1570 #1591 #1602 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2497 #2557 #2731 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 #M258 2436C > A #1024 2443_2444delinsAA 81R > K #1024 2448G > A #767 2452_2456delinsGAGGC 84DS > KA #1024 2454C > A 84D > E #2102 2461G > C 87D > H #1010 2465A > T 88N > I #1010 2466C > T #1449 2478G > A #471 2499G > A #767 2502T > C #1704 2508G > T 102E > D #1273 2511C > T #1020 #1024 #129 #1350 #1449 #1591 #2040 #2112 #217 #2208 #2320 #2806 #3013 #3086 #3142 #3511 #3765 #387 #471 #508 #685 #777 2538C > A #1343 2546G > C 115G > A #1704 2548C > A #1704 2556C > T #1704 2565G > A #1704 #714 #767 #877 #M258 2565G > C #2557 2580T > C #1024 2584C > A 128P > T #2320 2604A > G #1343 #2112 #2141 #2557 #2806 #3086 #3765 #471 #714 #777 #M258 2606C > A 135P > H #2320 2606C > G 135P > R #2731 2613G > A #1273 #1343 #1350 #1449 #2112 #2141 #387 #685 #714 #777 2622G > T #667 #767 2625A > T #2320 2635C > G 145P > A #2320 2637G > A #2731 #508 2643G > A #471 2642_2705delins_56nt 147_168delins_22aa #2731 2646_2647delinsTG 149S > A #2320 2646C > T #2497 #3013 2651C > A 150P > H #2320 2654T > C 151V > A #1024 #1260 #129 #1534 #1591 #1704 #2112 #2128 #2206 #2208 #2557 #3013 #3142 #3511 #3765 #387 #471 #473 #508 #685 #714 #767 #877 #M258 2655G > T #2208 2658G > A #2040 #508 2664C > T #1024 #1704 #2208 #3511 #387 2670C > T #1017 2673G > C #1024 #1449 #1704 #2208 #3511 #387 2678C > T 159T > I #714 2679C > T #1024 #1449 #1704 #2208 #3511 #387 2679C > A #2087 2685G > A #1010 #1017 #1020 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1534 #1570 #1591 #1602 #163 #2040 #2087 #2107 #2112 #217 #2206 #2557 #2731 #2806 #3086 #367 #371 #3765 #442 #471 #473 #667 #668 #685 #704 #714 #767 #777 #790 #M258 2686G > T 162A > S #1024 #1449 #1704 #2208 #3511 #387 2692C > A 164Q > K #2112 2692_2694delinsAAC 164Q > N #1534 #1704 #1919 #2087 #2102 #2128 #2141 #2206 #2557 #3142 #3765 #387 #471 #508 #790 #877 #M258 2694G > A #1024 #1449 #2208 #2806 #3086 #3511 2703A > G #1343 #2112 #2806 #3013 #3086 #777 2705G > A 168R > K #2806 #3086 2709A > G #1273 #1343 #1704 #1919 #2102 #2557 #3013 #3511 #387 #442 #508 #777 2713T > C #1017 #1158 #1260 #129 #1350 #1602 #2040 #2206 #2806 #3086 #3142 #3765 2716_2724delAATTTTGGT 172_175delNFG #1273 2718T > G 172N > K #2806 2721T > C #1010 #1017 #1158 #1260 #129 #1343 #1350 #1449 #1534 #1602 #1919 #2040 #2087 #2102 #2128 #2141 #2206 #2557 #3013 #3142 #387 #442 #471 #473 #508 #667 #668 #685 #714 #767 #777 #877 #985 #M258 2724T > C #1010 2734_2742delinsCCTTATGCT 178DA > PY #1055 2737G > T 179A > S #1602 2742C > T #2731 2744_2751delinsGGCATTGC 181_183delinsWHC #2731 2745A > C #1010 #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1591 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2557 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 #M258 2746_2776delins_31nt 182_192delins_SSRDMRKVFSA #1602 2751T > A #2208 2757C > T #2208 2760G > A #2102 #2128 #2208 2764C > A 188L > I #3142 2770C > A 190Q > K #1158 2770C > G 190Q > E #2208 #M258 2772G > A #2208 #442 #790 #M258 2788T > A 196S > T #129 #1602 #2208 #3142 #508 #M258 2790T > A #129 #1602 #2208 #3142 #508 #M258 2791G > A 197G > S #129 #1602 #2208 #3142 #508 #M258 2794C > T #1286 #129 #1570 #1591 #1602 #163 #1704 #2107 #217 #2208 #2731 #3142 #367 #508 #685 #767 #M258 2800A > T 200T > S #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #217 #2208 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 2804A > C 201N > T #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2040 #2107 #217 #2208 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 2808G > A #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #217 #2208 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 2815A > T 205T > S #1017 #1602 #2087 #2206 #2208 #2320 #M258 2821A > G 207S > G #1602 #2208 #M258 2831_2851delins_21nt 210_217delinsLLLLESLS #2731 2833A > G 211M > V #1010 #1286 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2208 #367 #714 #767 #790 #976 #M258 2837C > A 212A > E #667 2853C > T #1010 #1020 #1024 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2208 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 2859C > T #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2208 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 2877G > A #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #2107 #2112 #217 #2208 #2320 #2731 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 2879_2880insG N227Kfs277 #M258 2899_2900delinsCA 233T > Q #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2208 #2320 #2731 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #985 2905A > C 235M > L #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2102 #2107 #2112 #217 #2208 #2320 #2731 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #985 2905A > T 235M > L #1591 2911G > A 237D > N #685 2922C > T #3142 2937A > C #1055 #1260 #1273 #1343 #1534 #1919 #2102 #3511 #371 #473 #777 #877 2946C > T #1055 #1260 #1273 #1286 #1343 #1449 #1534 #1919 #2040 #2087 #2102 #2128 #3013 #3511 #371 #3765 #387 #471 #473 #508 #777 #790 #877 #976 2964C > T #1024 2967C > T #1017 #1055 #1260 #1273 #1343 #1449 #1534 #1919 #2040 #2087 #2128 #2206 #3013 #3511 #371 #3765 #387 #471 #473 #777 #877 2970C > G #1055 #1260 #1273 #1343 #1449 #1534 #1919 #2040 #3013 #3511 #371 #3765 #471 #473 #777 #877 2970C > T #129 2976_2997delins_22nt 258_265delins_NFFQIKIN #1010 2976A > G #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1591 #1602 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #217 #2206 #2208 #2320 #2497 #2557 #2731 #3013 #3086 #3142 #3511 #367 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 2979A > G #1017 #1055 #1260 #1273 #1343 #1449 #1534 #1919 #2040 #2087 #2128 #2206 #2557 #3013 #3142 #3511 #371 #3765 #387 #471 #473 #508 #777 #877 2982T > C #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2102 #2107 #2112 #217 #2208 #2320 #2731 #3086 #3142 #367 #442 #508 #668 #704 #714 #790 #976 #985 2982T > A #1273 #1534 2984C > G 261S > C #667 2991A > G #1055 #1260 #1273 #1534 #1919 #2128 #2557 #3511 #387 2994A > T #1055 #1260 #1273 #1534 #1919 #2128 #2557 #3511 #387 3000C > T #1017 #1024 #163 #2206 #2320 #3142 #508 #790 #985 3000C > A #1343 #3013 #777 3001TCG > AGC #1055 #1260 #1273 #1286 #1534 #1602 #1919 #2208 #2557 #3511 #371 #473 #976 3003G > A #1017 #1020 #1158 #129 #1350 #1449 #1570 #1591 #163 #2040 #2087 #2107 #2112 #2128 #217 #2206 #2320 #2497 #2731 #3086 #3142 #367 #3765 #387 #442 #471 #667 #668 #685 #704 #714 #790 #877 #985 3006C > T #985 3007_3012delGACAAT 269_270delDN #767 3012T > C #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1591 #1602 #163 #1704 #1919 #2040 #2087 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2497 #2557 #2731 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #714 #777 #790 #877 #976 #985 3018C > T #790 3019_3020insC N273Kfs277 #M258 #M258 3025_3026insC N255Kfs277 #M258 #M258 3028A > T #M258 3032C > A #M258 3035_3536delinsGG 278P > R #667 3036T > C #1017 #1020 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1534 #163 #1919 #2102 #2112 #2141 #217 #2206 #2320 #2557 #2806 #3142 #3511 #367 #371 #387 #442 #473 #508 #668 #704 #714 #767 #790 #877 #976 #985 #M258 3043T > G 281Y > D #667 3072C > T #1343 3075T > C #1017 #1343 #1704 #2206 #3013 #3511 #777 3078A > G #1017 #1055 #1343 #1704 #2206 3078A > C #3013 #3511 #777 3084T > C #1055 #1704 3087C > T #1020 #1704 #367 #767 3093A > G #1017 #1055 #2206 3111C > T #1017 3123A > T #1343 #1449 #1602 #2040 #2102 #2208 #3142 #3765 #387 #777 3123A > G #1055 #1273 #1286 #1602 #1704 #2087 #2102 #2141 #2208 #3142 #3511 #387 #442 #473 #667 #685 #777 #877 #976 #M258 3126C > A #1273 #1534 #2557 #471 #473 3129G > A #1055 #1273 #1534 #2087 #2102 #2208 #2320 #2497 #2557 #2806 #3086 #3142 #387 #473 #667 #685 #714 #777 #M258 3131G > A 310R > K #163 #985 3137A > G 312N > S #3511 3147C > G #1017 #1055 #2102 #2208 #387 3147C > T #2087 3147C > A #371 3151_3152delinsCT 317N > L #1010 3165A > G #1055 #1273 #1343 #1350 #1449 #1534 #2320 #2557 #3013 #3142 #3511 #387 #471 #473 #777 #877 3191C > A 330T > K #217 3192G > A #1273 #1286 #1534 3195_3198delinsCCCC 332I > P #217 3198T > C #3765 3236A > G 345D > G #985 3242A > G 347E > G #985 3247_3248delinsGG 349Q > G #985 3250C > A 350L > I #M258 3254C > G 351P > R #985 3261C > T #3765 3264C > T #2087 3264C > G #473 3267C > T #1017 3276T > C #1020 #217 #367 #668 3287T > C 362L > P #2208 3297C > T #1024 #1158 #1343 #1570 #1591 #163 #1919 #2107 #2320 #2731 #3142 #508 #714 #777 #790 #985 3303A > G #1010 #1020 #1024 #1158 #1260 #1343 #1570 #1591 #1602 #163 #1919 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #508 #667 #668 #704 #714 #767 #777 #790 #985 3309C > T #2497 #442 3312C > T #685 3318G > C #1010 #1020 #1158 #1260 #1286 #1343 #1350 #1570 #1602 #163 #1704 #2107 #2141 #217 #2320 #2497 #2806 #3086 #3142 #367 #442 #508 #668 #685 #777 #790 #976 #985 3318G > T #667 #767 3333C > T #976 3342G > A #1024 #1449 #3142 #471 3351G > A #2128 3357G > A #1449 #2040 #3765 #471 #714 3360A > G #1010 #1017 #1020 #1024 #1055 #1158 #1260 #129 #1343 #1350 #1570 #1591 #1602 #163 #1704 #1919 #2102 #2107 #2112 #217 #2208 #2320 #2497 #2806 #3013 #3086 #3142 #3511 #367 #442 #473 #508 #667 #668 #685 #714 #767 #777 #790 #976 #M258 3363A > C #1055 #2102 3375A > C #1020 #1024 #1055 #1158 #129 #1343 #1350 #1449 #1570 #1591 #1602 #163 #1704 #1919 #2102 #2107 #217 #2208 #2320 #3086 #3142 #367 #371 #442 #473 #508 #667 #668 #685 #767 #777 #790 #976 #985 #M258 3385C > T #442 #M258 3387G > A #387 3390G > A #3765 3405G > A #2087 #2102 #2128 #2320 #508 3411G > T #1020 #1055 #1260 #1273 #1449 #1534 #1919 #2040 #2102 #2112 #2208 #2557 #3765 #471 #473 #704 #877 3411G > A #1704 3417C > T #1010 #1020 #1158 #1286 #1350 #1570 #1591 #1602 #163 #2107 #2112 #2320 #2497 #2731 #3086 #3142 #3511 #367 #442 #508 #668 #685 #704 #790 #976 #985 #M258 3417C > A #1024 #1055 3426C > T #1704 3429T > C #1704 #M258 3430ACC > CAG 410T > Q #2497 #2731 #1602 #1010 #985 #1591 #508 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3430ACC > CAA 410T > Q #M258 3435C > T #1602 #790 #976 3441C > T #1449 #2040 #2141 #3765 #471 3444T > C #1010 #1017 #1020 #1055 #1158 #1260 #1286 #1343 #1350 #1449 #1534 #1570 #1591 #163 #1919 #2040 #2087 #2102 #2107 #2112 #2141 #2206 #2208 #2320 #2497 #2557 #2731 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #667 #668 #685 #704 #714 #777 #790 #877 #976 #985 #M258 3444T > A #2128 3450G > A #1010 #1020 #1024 #1055 #1158 #1260 #1286 #1350 #1534 #1570 #1602 #163 #1704 #1919 #2102 #2107 #2112 #2128 #217 #2208 #2320 #2497 #2557 #2731 #3086 #3142 #367 #442 #473 #508 #667 #668 #685 #704 #714 #790 #877 #976 #985 #M258 3453C > T #2141 3456T > G #1024 #1534 #2128 #2557 #508 #877 3459T > G #2141 3463_3465delinsACA 421H > T #2141 3471C > A 423S > R #2141 3474C > T #3142 3483C > T #1260 #1534 #1919 #2102 #2208 #2557 #473 #877 3486G > A #1260 #1534 #1919 #2102 #2208 #2557 #473 #877 3490C > T #1017 #1273 #1343 #1449 #1919 #2040 #2087 #2128 #2141 #2206 #2497 #3013 #3511 #371 #3765 #387 #471 #508 #777 3495C > T #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3496C > A #2112 3498T > G #1010 #1020 #1024 #1158 #1286 #1343 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #3086 #3142 #367 #442 #471 #508 #667 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 3498T > C #3765 3501C > G #1158 #1286 #129 #1343 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 3501C > A #1024 3513C > G #1010 #1020 #1024 #1158 #1286 #1343 #1350 #1570 #1591 #1602 #163 #2107 #2112 #217 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 3516C > T #1591 #163 #2112 #2320 #2806 #3086 #704 #790 #985 3525C > T #1343 #777 3528G > A #1260 3534C > T #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3535T > C #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3537G > A #1024 #1260 #129 #508 #685 #790 3539G > A 446S > N #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3541A > G 447R > G #2102 3542G > A 447R > K #1010 #1020 #1158 #1286 #1343 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 3543A > G #1024 #1158 #1350 #1591 #1602 #163 #1704 #2320 #2806 #3086 #3142 #442 #508 #668 #685 #714 #790 #976 #985 #M258 3547_3549delinsCAA 449N > Q #129 #2731 #1602 #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3547_3549delinsCAG 449N > Q #1350 3550A > T 450T > S #1010 #1020 #1158 #1286 #1350 #1591 #163 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3550A > G 450T > A #1343 #1570 #777 3552T > A #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #790 #976 #985 #M258 3552T > G #1055 #1260 #2206 3552_3554delTCC 451delP #767 3553_3555delinsAAT 451P > N #2731 #1602 #1010 #985 #2806 #217 #1591 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #790 #976 #1286 #163 #685 #442 #2320 3553_3555delinsGCC 451P > A #M258 #508 #1024 3555A > G #1260 #1055 3555A > C #129 3558T > C #1017 #1055 #1260 #1273 #1343 #1449 #1534 #1919 #2040 #2087 #2102 #2128 #2206 #2208 #2497 #2557 #3013 #3511 #371 #3765 #387 #471 #473 #777 #877 3560G > A 453G > E #2806 3564C > T #1010 #1020 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3564_3566delCAC 454T_del #1024 #508 3564C > A #2806 #442 3565_3567delinsCTT 455T > L #1602 #1010 #985 #767 #1591 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #790 #976 #1286 #163 #685 #442 #2320 3565_3567delinsGTT 455T > V #M258 #3142 3565A > C 455T > P #129 3566C > A 455T > N #217 3567C > T #1017 #1273 #877 #2557 #1919 #1260 #2208 #2806 3567_3620delins_54nt 456_473delins_18aa #2806 3568_3569delinsCA 456T > Q #1602 #1010 #985 #M258 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #976 #1286 #163 #685 #442 #2320 3568_3570delinsCAA 456T > Q #790 3571_3572delinsAT 457Q > M #1343 #777 #3511 #3013 #2731 3576A > T #777 #129 #1602 #1010 #667 #M258 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3576A > C #2102 #371 #1017 #473 #1273 #2087 #2206 #877 #1534 #2557 #1919 #1260 #3765 #471 #387 #2040 #1449 #2128 #1343 #3511 #3013 #2208 #1055 #2806 3577A > C #129 #1602 #1010 #667 #M258 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3579G > A #2206 3580C > T #767 3582T > A #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3584A > T 461Q > L #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3589_3590delinsAG #2731 #1010 #667 #767 #1591 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #790 #1286 #163 #2320 3589_3591delinsAGC #129 #1602 #M258 #508 #3086 #3142 #1024 #976 #685 #442 3594G > A #1010 #1020 #1024 #1158 #1286 #129 #1350 #1449 #1570 #1591 #1602 #163 #1704 #2107 #2112 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3597C > T #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3597C > A #1343 3601_3603delinsCCC 467A > P #129 #2731 #1010 #667 #M258 #767 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3601_3603delinsCCA 467A > P #1602 3603G > A #2102 #2206 #1919 #1260 #3765 #471 #387 #1449 #2128 #1343 #777 3605_3606delinsCC 468S > T #2731 #1602 #1010 #667 #M258 #767 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3605_3606delinsCA 468S > T #129 #2806 3607_3608delinsAG 469D > S #129 #2731 #1010 #667 #2806 #M258 #767 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3607G > A 469D > N #1602 #3086 3612T > G 470I > M #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2107 #2112 #2320 #2731 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3613_3615delinsTCT 471R > S #129 #2731 #1602 #1010 #667 #M258 #767 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3616_3618delinsCTT 472D > L #129 #2731 #1602 #1010 #667 #M258 #767 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3618C > T #2141 3621G > A 473Q > H #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2107 #2112 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3621G > C #2731 3622T > G 474S > A #1010 #1020 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2107 #2112 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3624T > C #2806 3626_3627delins > AA 475R > K #129 #2731 #1602 #1010 #667 #M258 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3627G > A #1343 #777 #2806 3628_3629delinsGT 476N > V #2806 3630C > T #442 3636T > G #1010 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3636T > A #1020 3645C > T #1020 #1024 #1158 #1286 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3645C > G #129 3648T > C #1020 #1024 #1158 #1286 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3651C > T #129 #2141 3652C > A #1020 #1024 #1158 #1286 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3654C > A #1020 #1024 #1158 #1286 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3657G > A #1024 3660G > A #371 3663A > T #1020 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3664_3666delinsTTG 488V > L #129 #3086 #1024 3664_3666delinsCTG 488V > L #2731 #1602 #667 #M258 #217 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3142 #790 #976 #1286 #163 #685 #442 #2320 3664G > T 488V > L #2806 3672G > A #1017 #1350 3673_3675delinsCAG 491T > Q #129 #2731 #1602 #667 #2806 #M258 #217 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3676T > G 492S > A #1020 #1024 #1055 #1158 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1602 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #217 #2208 #2320 #2497 #2557 #2731 #2806 #3013 #3086 #3142 #3511 #367 #442 #473 #508 #667 #668 #685 #704 #714 #777 #790 #877 #976 #M258 3676T > C 492S > P #3765 #387 #471 3678T > A #1020 #1024 #1158 #1286 #129 #1350 #1570 #1602 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3679_3681delinsAAC 493A > N #129 #2731 #1602 #667 #2806 #M258 #217 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #1024 #790 #976 #1286 #163 #685 #442 3679_3681delinsAGC 493A > S #3142 3679G > A 493A > T #2320 3681G > A #2128 3684T > C #1020 #1024 #1158 #1273 #1286 #129 #1343 #1350 #1570 #1602 #163 #1704 #2087 #2102 #2107 #2112 #217 #2497 #2557 #2731 #2806 #3013 #3086 #3142 #3511 #367 #442 #508 #667 #668 #685 #704 #714 #777 #790 #877 #976 3684T > A 494D > E #M258 3687C > A 495N > K #767 3689A > G 496N > S #2102 #2497 3690C > T #2806 #3086 3693C > T #1024 #2128 3693delC N497Kfs511 #2112 3696T > C #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #217 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #M258 3697_3699delinsAAC 499E > N #129 #2731 #1602 #667 #2806 #M258 #217 #1591 #508 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 3697_3699delinsAAT 499E > N #1704 3699A > T 499E > D #1343 #777 #3511 #3013 3699A > G #2497 #2102 #2087 3701_3702delinsTT 500Y > F #129 #2731 #1602 #667 #2806 #M258 #217 #1591 #1704 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3702C > T #371 #1534 3703_3705delinsCCC 501S > P #129 #2731 #1602 #667 #2806 #M258 #217 #1591 #1704 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3711T > A #217 3713_3714delinsCG 504G > A #667 #M258 #767 #1591 #1704 #1350 #668 #367 #1158 #704 #714 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3713G > C 504G > A #2731 #1602 #2806 #1020 #2107 #1570 #3086 3714A > T #2497 3720C > A #1020 #1024 #1158 #1286 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2112 #2320 #2731 #2806 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3723G > A #371 3726C > T #1020 #1158 #1286 #1350 #1570 #1591 #1602 #163 #1704 #2107 #2320 #2731 #2806 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3728A > C 3729C > T #1020 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #2320 #2731 #2806 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3732C > A #1020 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #2731 #2806 #3086 #3142 #367 #667 #668 #685 #704 #714 #767 #790 #976 3733_3734insT #2112 3734_3756delins_26nt 511_518delinsGYKVSTKW #2112 3738C > A #1343 #2087 #2102 #2497 #777 3738C > T #387 #508 3739_3741delinsCGG #3511 #3013 #667 #2806 #M258 #767 #1591 #1704 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #790 #976 #1286 #163 #685 #442 #2320 3741A > T 513R > S #2731 3747T > G #1020 #1158 #1286 #1350 #1570 #1591 #163 #2107 #2320 #2731 #2806 #3013 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3747T > A 3748C > T #1020 #1055 #1158 #1286 #129 #1350 #1570 #1591 #163 #2107 #2112 #2320 #2731 #2806 #3013 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3751_3753delinsATT 517V > I #2731 3753G > T #3013 #667 #2806 #M258 #767 #1591 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #790 #976 #1286 #163 #685 #442 #2320 #1449 3753G > A #1449 3756T > C #129 #508 3759G > A #1020 #1158 #1286 #1350 #1570 #1591 #163 #1704 #1919 #2107 #2320 #2731 #2806 #3013 #3086 #3142 #3511 #367 #442 #667 #685 #704 #714 #767 #790 #976 #M258 3762C > A #1020 #1158 #1286 #1570 #1591 #163 #1704 #2107 #2112 #2320 #2731 #2806 #3013 #3086 #3142 #3511 #367 #442 #667 #685 #704 #714 #767 #790 #976 #M258 3762C > G #1350 3763_3765delinsACA 521P > T #1343 #777 3765G > A #3511 #3013 #2731 #667 #2806 #M258 #217 #767 #1591 #1704 #2112 #1350 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #790 #976 #1286 #163 #685 #442 #2320 3765G > T #508 #1024 3768C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #M258 3774A > C #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1591 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2497 #2557 #2731 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #714 #767 #777 #790 #877 #976 #M258 3777C > T #1020 #1024 #1704 #2141 #2806 #3086 #3142 #M258 3780C > T #2806 #3086 3783G > A #1024 #1158 #1286 #1350 #1570 #1591 #163 #2107 #2112 #2141 #217 #2320 #2731 #2806 #3013 #3086 #3511 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 3786C > T #1020 #1704 #3142 #442 #714 #M258 3789T > C #1020 #1704 #3142 #714 #M258 3795A > G #1449 3795_3796insGAA 531_533insE #1570 3800T > A 533F > Y #1343 #3013 #3511 #777 3804T > C #1020 #1024 #1158 #1286 #129 #1350 #1449 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3807T > C #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3808_3809delinsAT 536Q > M #129 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3810G > A #1055 #1449 #1534 #2040 #2087 #2206 #2208 #2557 #371 #3765 #471 #877 3810G > C 536Q > H #2497 3811_3813delinsCAT 537S > H #129 #M258 #217 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3811_3813delinsCCT 537S > P #767 3816G > A #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3817_3819delinsACC 539V > T #129 #M258 #217 #767 #1591 #508 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3817_3819delinsACA 539V > T #1704 3820C > T #1704 3822C > G #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3822C > A #129 3825C > A #1020 #1024 #1158 #1260 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3828T > C #1343 #3013 #777 3831G > A #371 #1017 #473 #1273 #2206 #2128 #1343 #777 #3511 #3013 3831G > T #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3834G > A #1017 #1020 #1024 #1158 #1273 #1286 #1343 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2206 #2320 #2806 #3013 #3086 #3142 #3511 #367 #371 #442 #473 #508 #668 #685 #704 #714 #767 #777 #790 #976 #M258 3835C > G 545Q > E #1024 #3142 #508 #767 3839G > A 546G > D #1017 #1273 #1343 #3013 #3511 #473 #777 3840C > A #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3840C > T #2128 #1343 3841T > A 547S > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3843A > G #1273 #1343 #3013 #3511 #777 3843A > T #2320 #442 #M258 3844_3846delinsAAT 548E > N #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #1024 #790 #976 #1286 #163 #685 3845_3846delinsGA 548E > G #1017 #473 #1273 #1343 #777 #3511 #3013 #M258 #442 3844_3846delinsAAA 548E > K #2320 3844_3846delinsACT 548E > T #3142 3847A_3849delinsGCT 549K > A #217 #767 #1591 #508 #2112 #1350 #668 #367 #1158 #2107 #1570 #704 #714 #1024 #790 #976 #1286 #163 3847A_3849delinsTCT 549K > S #3142 3847A_3849delinsTGC 549K > C #2320 3848A > G 549K > R #M258 #442 3847_3849delinsGCC 549K > A #1704 #1020 #3086 #685 3850_3852delinsGAC 550T > D #M258 #442 3851_3852delinsAC 550T > N #217 #767 #1591 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #790 #976 #1286 #163 #685 #2320 3852A > T #1017 #473 #1273 #1343 #777 #3511 #3013 3852A > C #129 #2806 #508 #1024 3853_3855delinsGAC 551N > D #217 #1591 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #790 #976 #1286 #163 #685 #2320 3855T > C #129 #M258 #767 #508 #3142 #1024 #442 3857T > C 552V > A #129 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3858G > A #217 #767 #367 3859_3864del 553_554delVD #2128 3861C > T #M258 #217 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3861C > A 553D > E #129 #767 3862_3864delinsTTG 554I > L #129 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3867A > C 555E > D #1024 #1158 #1286 #1350 #1570 #1591 #163 #2107 #2112 #217 #2320 #3086 #367 #442 #508 #668 #685 #704 #714 #790 #976 #M258 3868_3870delinsCAT 556K > H #3142 3870G > T 556K > N #1020 #1024 #1158 #1286 #129 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #M258 3873C > T #1286 #1591 #1704 #2320 #3511 3885C > T #1024 #1158 #1286 #129 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #442 #668 #685 #704 #714 #767 #790 #976 #M258 3887A > G 562E > G #2141 3891G > A #1010 #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #3086 #3142 #367 #387 #442 #668 #685 #704 #714 #767 #790 #976 #M258 3898_3900delinsCGC #1010 #M258 #217 #767 #1591 #2112 #1350 #668 #367 #1158 #2107 #1570 #704 #3086 #1024 #790 #976 #1286 #163 #685 #442 #2320 3903A > C #1010 #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1591 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2497 #2557 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #668 #685 #704 #714 #767 #777 #790 #877 #976 #M258 3906C > A #1024 #3086 #508 3906C > T #3142 3912C > T #1024 #3086 #3142 #508 3912C > A #976 3915G > A #1024 #1158 #3086 #508 3915G > C #2141 3918T > C #2141 3921G > A #129 #371 3930T > C #1010 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3933T > A #1010 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2731 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3933T > G #1020 3934T > G 578S > A #2497 #1449 #1020 3935C > A 578S > Y #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1158 #2107 #1570 #704 #714 #3086 #1024 #790 #976 #1286 #163 #685 #442 #2320 3934_3935delinsAA 578S > N #3142 3939A > G #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #685 #442 #2320 3939A > C #163 3942T > A #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3944_3945delinsAT 581T > N #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3948C > T #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3949_3951_delinsTTG #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3951C > T #3013 3954G > A #1343 #777 #3013 #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3956_3957delinsAC 585R > N #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3957A > C 585R > S #2497 #2102 #371 #1017 #473 #1273 #2087 #2206 #877 #1534 #2557 #1919 #1260 #3765 #471 #387 #2040 #1449 #2128 #1343 #777 #3511 #3013 #2208 #1055 #1350 3958_3960delinsTCA 586G > S #1010 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3963C > T #1010 #985 #667 #2806 #217 #767 #1591 #2112 #668 #367 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #163 #685 #2320 3965_3966delinsCT 588R > T #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 3959G > C 588R > T #2497 #2102 #371 #1017 #473 #1273 #2087 #2206 #877 #1534 #2557 #1919 #1260 #3765 #471 #387 #2040 #1449 #2128 #2141 #1343 #777 #3511 #3013 #2208 #1055 #1350 3967_3969delinsGGT 589Q > G #985 #667 #2806 #217 #767 #1591 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #790 #976 #1286 #163 #685 #442 #2320 3968A > G 589Q > R #2731 3967_3969delinsGCT 589Q > A #M258 #508 #1024 3970G > C 590A > P #1020 #1158 #1286 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3972A > G #M258 3973G > A 591A > T #985 #667 #2806 #217 #767 #1591 #508 #1704 #2112 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 3973_3974delinsAG 591A > S #M258 3978C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3979G > T 593A > S #1017 #1055 #1260 #1273 #1343 #1449 #1534 #1919 #2087 #2102 #2206 #2208 #2497 #3013 #3511 #473 #777 3980C > G 593A > G #985 #667 #2806 #M258 #217 #767 #1591 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #790 #976 #1286 #163 #685 #442 #2320 3980C > A 593A > E #508 #3142 #1024 3982_3983delinsAC 594D > T #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #1024 #790 #976 #1286 #163 #685 #442 #2320 3982G > A 594D > N #3142 3987C > A #163 3990C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 3991A > G 597T > A #1017 #473 #1273 #1260 3991_3993delinsCAC 597T > H #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #1024 #790 #976 #1286 #163 #685 #442 #2320 3992_3993delinsAC 597T > N #3142 3999C > T #1017 #1273 #2087 #1260 3999C > A #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 4000G > A 600V > I #2497 #1449 4001_4002delinsCG 600V > A #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 4003_4005delinsTTA #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 4006C > T 602P > S #777 4008A > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3013 #3086 #3142 #3511 #367 #371 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4011C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4017C > G #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4017C > A #2557 4026C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2320 #2806 #3086 #3142 #367 #442 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4027A > C #1020 #1158 #1286 #1350 #1570 #1591 #163 #2107 #2112 #217 #2320 #2806 #3086 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 4032T > C #1020 #1024 #1055 #1158 #1260 #1273 #1286 #1343 #1350 #1449 #1570 #1591 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2497 #2557 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 #M258 4035G > A #1704 4041T > G #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #1343 #1350 #1449 #1534 #1570 #1591 #163 #1919 #2087 #2102 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2497 #2557 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #667 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 #M258 4041T > A #1704 #508 4047G > A #1020 #1024 #1158 #1286 #1343 #1350 #1449 #1570 #1591 #163 #2107 #2112 #217 #2208 #2320 #2497 #2806 #3013 #3086 #3142 #3511 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4047G > T #1704 4050C > T #1534 #2102 #2141 #2557 #387 #877 4053C > T #1020 #1024 #1158 #1286 #1350 #1449 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #3142 #367 #442 #471 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4053C > A #2806 #3086 4059A > C #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4062G > A #1024 #471 4068A > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4068A > C #1260 #2128 #777 4074G > C #1020 #1024 #1158 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4074G > A #2206 4077C > T #1020 #1024 #1158 #1350 #1570 #1591 #163 #1704 #2107 #2112 #2128 #217 #2208 #2320 #2806 #3086 #367 #3765 #442 #471 #508 #667 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 4083T > C #1020 #1024 #1158 #1260 #1350 #1570 #1591 #163 #1704 #2107 #2112 #2128 #217 #2208 #2320 #2497 #2806 #3013 #3086 #3142 #3511 #367 #3765 #442 #471 #508 #667 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 4089C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #767 #790 #976 #985 #M258 4092C > T #1020 #1024 #1158 #1260 #1286 #1343 #1350 #1570 #1591 #163 #1704 #2107 #2112 #2128 #217 #2208 #2320 #2497 #2806 #3013 #3086 #3142 #3511 #367 #3765 #442 #471 #508 #667 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 4095T > C #777 4098C > A #1020 #1158 #1286 #1350 #1591 #163 #2112 #217 #2320 #367 #442 #668 #685 #714 #767 #790 #976 #985 4098C > G #1024 #1570 #1704 #2107 #2208 #2806 #3086 #3142 #704 #777 #M258 4098C > T #1260 #1343 #2128 #3765 #471 4101C > G #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #367 #442 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4101C > T #1260 #1343 #2128 #3142 #3765 #471 4107T > C #1017 #1055 #1260 #1273 #1534 #1919 #2040 #2087 #2141 #2206 #2557 #3013 #3511 #371 #387 #508 #877 4107T > A #1020 #1024 #1158 #1286 #1343 #1350 #1570 #1591 #163 #1704 #2107 #2112 #2128 #217 #2208 #2320 #2806 #3086 #3142 #367 #3765 #442 #471 #668 #685 #704 #714 #767 #777 #790 #976 #985 #M258 4110A > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4113C > T #1020 #1024 #1055 #1158 #1286 #1343 #1350 #1534 #1570 #1591 #163 #1704 #2087 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2557 #2806 #3013 #3086 #3142 #3511 #367 #3765 #442 #471 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 #M258 4116A > G #1020 #1158 #1286 #1350 #1570 #1591 #2107 #2112 #217 #367 #668 #685 #767 #790 4117C > T #2087 #2206 4119T > G #1017 #1055 #1343 #1919 #2087 #3013 #3511 #877 4119T > C #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4119T > A #2206 4122A > G #1055 #1343 #1919 #2087 #2206 #3013 #3511 #877 4123C > A 641H > N #508 4128T > G #1020 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #367 #668 #685 #714 #790 #985 4128T > A #1024 #2208 #2320 #3086 #3142 #442 #508 #704 #767 #976 #M258 4128T > C #1343 4131T > C #1260 #1343 #2087 #2128 #2141 #2206 #3013 #3511 #3765 #471 #473 #777 4134A > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #3086 #3142 #367 #442 #508 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4134A > G #1260 #1343 #2040 #2087 #2128 #2141 #2206 #3013 #3511 #3765 #387 #471 #473 #777 4137G > A #1017 #1273 #2040 #2206 #3142 #387 4140T > C #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4141_4143delinsATG 647L > M #2208 #985 #667 #2806 #M258 #217 #767 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #1570 #704 #714 #3086 #3142 #1024 #790 #976 #1286 #163 #685 #442 #2320 4146C > T #1055 #2206 #442 4149G > A #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2102 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #3765 #442 #471 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4151A > G 650N > S #667 4152C > T #1055 #1343 #2206 #3013 #3511 #777 4153A > T 651T > S #667 4155C > T #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4158G > C #1020 #1024 #1158 #1286 #1350 #1591 #163 #1704 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #714 #767 #777 #790 #976 #985 #M258 4158G > A #1055 #1570 #2107 #704 4158G > T #1273 4161A > T #1010 #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4164T > A #1010 #1020 #1024 #1158 #1286 #1350 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4165_4209delins_46nt 655_669delins_15aa #1570 4167G > C #1010 #1020 #1024 #1158 #1286 #1350 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4167G > A #1534 #2206 #2557 4174T > C 658S > P #1010 #1020 #1024 #1158 #1286 #1350 #1570 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4176G > T #1010 #1020 #1055 #1158 #1286 #1343 #1570 #1591 #217 #2206 #3013 #3086 #3142 #367 #667 #767 #790 #877 #976 #M258 4176G > A #1017 #471 #685 4176G > C #1024 #1350 #163 #1704 #2107 #2112 #2208 #2320 #442 #508 #668 #704 #714 #985 4178C > G 4179C > A #1010 #1020 #1024 #1158 #1286 #1350 #1591 #163 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4179C > G #1704 4181C > A 660T > N #1010 #1020 #1024 #1158 #1286 #1350 #1591 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #767 #790 #976 #985 #M258 4182C > T #2206 #3765 #714 #877 4185C > T #1024 #1570 #2128 #2320 4188T > C #1055 #1260 #1343 #2206 #3013 4189_4191delinsTCT 663A > S #2208 #1010 #985 #667 #2806 #217 #1591 #508 #1704 #2112 #1350 #668 #367 #1020 #1158 #2107 #704 #714 #3086 #790 #976 #1286 #163 #685 #442 #2320 4191G > A #2087 #3765 #471 4192G > T 664A > S #1602 #1570 4194A > C #1010 #1020 #1158 #1286 #1350 #1591 #1602 #163 #1704 #2107 #2112 #217 #2208 #2320 #2806 #3086 #367 #442 #508 #667 #668 #685 #704 #714 #790 #976 #985 4197G > A #767 #877 #M258 4206C > T #1010 #1020 #1024 #1158 #1286 #1350 #1534 #1591 #1602 #163 #1704 #2107 #2112 #217 #2206 #2320 #2557 #2806 #3086 #3142 #367 #442 #508 #667 #668 #685 #704 #714 #790 #877 #976 #985 4209C > T #2141 #473 #767 #985 #M258 4212C > T #1273 #2208 #371 #3765 #471 4221C > T #1024 #1055 #1158 #1260 #1286 #129 #1350 #1570 #1591 #1602 #163 #1704 #1919 #2040 #2087 #2107 #2112 #2128 #2208 #2320 #2806 #3086 #3765 #387 #442 #508 #668 #685 #767 #777 #976 #985 #M258 4230A > G #1010 #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #1343 #1350 #1449 #1534 #1570 #1602 #163 #1704 #1919 #2087 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2557 #2806 #3013 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #704 #714 #767 #777 #790 #877 #976 #985 4233G > A #1024 #1570 #2107 #2320 4239C > T #2128 #2557 4239C > A 679S > R #2806 4242G > A #1260 4245G > A #1260 #714 #767 4248C > T #2557 #685 4248C > A #3511 4251G > A #1055 #371 4258C > T #2040 #387 4260G > A #1286 #1534 4263G > A #1055 4266G > A #1273 #1343 #1449 #3142 #371 #668 #777 4269A > G #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1350 #1449 #1534 #1570 #1591 #1602 #163 #1704 #1919 #2040 #2087 #2107 #2112 #2128 #2141 #217 #2206 #2208 #2320 #2557 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #714 #767 #777 #790 #877 #976 #985 #M258 4278A > G #2128 #2208 4287T > C #1024 #129 #1343 #1449 #1570 #2087 #2102 #2107 #2128 #2208 #2320 #3013 #3086 #3142 #3511 #3765 #387 #442 #668 #704 #777 #790 #M258 4290C > T #2208 #387 4293A > G #1010 #1020 #1024 #1260 #1273 #129 #1343 #1449 #1534 #1570 #1602 #163 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2141 #2206 #2208 #2320 #2557 #2806 #3013 #3086 #3142 #3511 #367 #371 #3765 #387 #442 #471 #473 #508 #667 #668 #685 #704 #767 #777 #790 #877 #976 #985 #M258 4296T > C #1024 #1260 #129 #1343 #1449 #1570 #1704 #1919 #2040 #2087 #2102 #2107 #2112 #2128 #2208 #2320 #2497 #2557 #2806 #3013 #3086 #3142 #3511 #3765 #387 #442 #508 #668 #704 #767 #777 #M258 4299G > A #2128 #2206 #471 4302C > T #1158 #1286 #3511 #714 4308C > A #1055 #367 #667 #877 4308C > T #3086 4311C > T #1449 #3142 4314C > T #1260 #1919 #2087 #2208 #668 4320G > A #1010 #1017 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1449 #1534 #1570 #1591 #1602 #163 #2040 #2102 #2107 #2128 #217 #2206 #2208 #3013 #3086 #3142 #3511 #371 #3765 #442 #471 #473 #685 #714 #790 #976 4331T > C 710V > A #2557 4336T > C 712F > L #2557 4344G > A #1273 4356C > T #1010 #1020 #1024 #1055 #1158 #1260 #1273 #1286 #129 #1343 #1449 #1534 #1570 #1591 #1602 #163 #1919 #2102 #2107 #2112 #2141 #217 #2206 #2208 #2497 #2557 #2806 #3086 #3511 #371 #3765 #387 #442 #471 #508 #667 #668 #685 #704 #714 #777 #790 #976 #M258 4369C > G 723P > A #129 4400G > T 733R > L #2102 4401T > C #163

An object of the present invention relates to a variant VP1 capsid protein that consists of the amino acid sequence as set forth in SEQ ID NO:2 comprising at least one mutation selected from the group consisting of V151A, Q164N; T200S; N201T; M211V; T233Q; M235L; T410Q; S446N; R447K; N449Q; T450S; P451N; T455L; T456Q; Q461L; A467P; S468T; D469S; I470M; R471S; D472L; S474A; R475K; V488L; T491Q; S492A; A493N; E499N; Y500F; S501P; G504A; Q536M; S537H; V539T; S547T; E548N; K549A; T550N; N551D; V552A; I554L; E555D; K556N; S578Y; T581N; R585N; R585S; G586S; R588T; Q589G; A590P; A591T; A593S; A593G; D594T; T597H; V600A; L647M; S658P; T660N; and A663S.

In some embodiments, the variant VP1 capsid protein of the present invention has an amino acid sequence selected from the group consisting of SEQ ID NO: 3 to SEQ ID NO:61.

A further object of the present invention relates to a variant VP1 capsid protein of the present invention has an amino acid sequence selected from the group consisting of SEQ ID NO:26 (i.e. capsid #3013), SEQ ID NO:9 (i.e. capsid #2087), SEQ ID NO: 20 (i.e. capsid #1449), SEQ ID NO: 10 (i.e. capsid #2206), SEQ ID NO: 12 (i.e. capsid #1534), SEQ ID NO: 56 (i.e. capsid #163), SEQ ID NO: 23 (i.e. capsid #1343), SEQ ID NO: 53 (i.e. capsid #790), SEQ ID NO: 6 (i.e. capsid #1017), SEQ ID NO: 11 (i.e. capsid #877), SEQ ID NO:8 (i.e. capsid #1273), SEQ ID NO: 3 (i.e. capsid #2497), SEQ ID NO: 60 (i.e. capsid #1055), SEQ ID NO:14 (i.e. capsid #1919), SEQ ID NO: 4, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:13, SEQ ID NO:15 to SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:27 to SEQ ID NO:55, SEQ ID NO:57 to SEQ ID NO:59, SEQ ID NO:61.

SEQ ID NO: 3 >#2497_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2497N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNSNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPHSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGTVSTNLQSGNTQAATSDVNTQGILPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 4 >#2102_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2102N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHQDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLESGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSGTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNSNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTLNL* SEQ ID NO: 5 >#371_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC371N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 6 >#1017_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1017N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMASGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQDSGKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNAQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 7 >#473_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC473N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQDSGKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNAQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 8 >#1273_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1273N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHQDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQDRLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTS TRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEV TQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQML RTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCY RQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQDSGKTNVDIEKVMITDEE EIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNAQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPP PQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEP RPIGTRYLTRNL* SEQ ID NO: 9 >#2087_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2087N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMASGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 10 >#2206_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2206N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMASGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 11 >#877_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC877N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 12 >#1534_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1534N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHQDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 13 >#2557_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2557N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNADLTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 14 >#1919_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1919N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 15 >#1260_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1260N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDGRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNAQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 16 >#3765_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC3765N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTPADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 17 >#471_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC471N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTPADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 18 >#387_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC387N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KSGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTPADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 19 >#2040_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2040N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTTTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 20 >#1449_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1449N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDNRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KSGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTPADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGTVSTNLQSGNTQAATSDVNTQGILPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 21 >#2128_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2128N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVEKVMITDE EEIRTTNPVATEQYGAVSTNLQSGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHP PPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSE PRPIGTRYLTRNL* SEQ ID NO: 22 >#2141_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2141N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFTSRYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DGEEIRTTNPVATEQYGSVSTNLQRGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 23 >#1343_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1343N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSKTNAPSGTTTMSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSDYSWTGATKYHLNGRDSLVNPGTAMASHKDDEEKYFPQSGVLIFGKQDSGKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 24 >#777_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC777N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSKTNAPSGTTTMSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSDYSWTGATKYHLNGRDSLVNPGTAMASHKDDEEKYFPQSGVLIFGKQDSGKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLSGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 25 >#3511_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC3511N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KSGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLSFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTMSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSDYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKYFPQSGVLIFGKQDSGKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 26 >#3013_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC3013N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTMSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSDYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKYFPQSGVLIFGKQDSGKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 27 >#2208_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2208N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KSGQQPARKRLNFGQTGDADSVPDPQPLGEPPAAPTSLGSTTMASGGGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCPPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 28 >#129_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC129N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHQDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPTSLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQTXSGTPTQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGSEKTNAELENVMIT DEEEIRTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEARPIGTRYLTRNL* SEQ ID NO: 29 >#2731_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2731N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEERVKTAPGKKRPVAVAHQWQTITRVPM EWVIPQEKRLNFGQTGDADWHCDPQPLGQPPAAPSGLGSTTMATGSGALLLLESLSADGVGNSSGNWHCDSQWLGDRVIT TSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVK EVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQ MLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTTTMSRLLFSQAGPTSMSLHAKNWLPGP CYRQQRLSKQANDNNNSNFPWTAATKYHLNGSDSLINPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITD EEEIRTTNPVATEQYGSVSTNLQRGNRRAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKH PPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYS EPRPIGTRYLTRNL* SEQ ID NO: 30 >#1602_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1620N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKSAERHKDDSRGLVLPGYKYLGPFXGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLXPLGXVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDSDSSSRDMRKVESAAAPTSLGSTTMASGGGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQTNSGTLQQSRLLFSQAGPTNMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKEXSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 31 >#1010_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1010N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLGETLSQGIRQWWKLKPGPPPPKPAERHKXDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGHIPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYNFFQIKINASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFLIQV KEVTQNDGTTTIANNLTSTVQVFTXSEYQLPYVLGSAHQGCXPPFPADVFMVPQYGYLTLNNGSQAXGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 32 >#985_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC985N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTPSAGISQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKKLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTGSGYGLRYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 33 >#667_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC667N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMEDNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQICSQSGASNDNHYFGYSTRWGDFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTXTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKSSXVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 34 >#2806_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2806N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDNSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPAKKRLKFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSETTFSSATPLKTFLSTAATLTARVWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVRVEIEWELQKENSKRWNPEIQYTSNYNKXVNVDFTVDTNGVY SEXRPIXTRXLTRNL* SEQ ID NO: 35 >#217_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC217N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTKTPANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTNTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRLSKQANDNNNSNFPWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 36 >#767_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC767N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKE VTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQM LRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSSGTLQQSRLLFSQAGPTSMSLQARNWLPGPCY RQQRVSKTSADKNNSEYSWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMPGTLIFGKEGTNANNAELENVMITDEE EIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPP PQIMIKNTPVPANPPTNFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEP RPIGTRYLTRNL* SEQ ID NO: 37 >#1591_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1591N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGASDIRDQSRNWLPG PCYRQQRVSKTSADNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 38 >#508_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC508N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAAIEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEXXGLVEEPVKTAPGKKRPVAHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPTSLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQTASGTQQSRLLFSQAGPTSMSLQAKNWLPGP CYRQQRLSKQANDNNNSNYSWTGATKYHLNGRDSLVXPGPAMASHXDDEXKFFPMHGTLIFGKEGTNATNADLDNVMITD EEEIRTTNPVATEQYGYVSNNLQNSNTAATTETVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKN PPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYS EPRPIGTRYLTRNL* SEQ ID NO: 39 >#1704_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1704N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLARAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KSGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQTNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLENVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 40 >#2112_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2112N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLQENLFFDIRQWWKLKPGPPPPKPAERHQDNSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGXQPAXKRLNFGQTGXADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNKAGKRQQQQQLSLDCGYKVSTKWPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMI TDEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGL KHPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGV YSEPRPIGTRYLTRNL* SEQ ID NO: 41 >#1350_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1350N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQSGNTQAATGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 42 >#668_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC668N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDNRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 43 >#367_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC367N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 44 >#1020_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1020N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLENVMIT DEEEIRTTNPVATEQYGTVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 45 >#1158_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1158N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGKPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSSKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 46 >#2107_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2107N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 47 >#1570_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1570N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQANSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEEKFFPMHGTLIFGKQGTNANDADLDNVMI TDEEEIRTTNPVATEQYXYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGL KHPPPQIMIKNTPVPSPLMGGFGLKHPPPQITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGV YSEPRPIGTRYLTRNL* SEQ ID NO: 48 >#704_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC704N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 49 >#714_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC714N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGIG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 50 >#3086_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC3086N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDNSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPAKKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTNMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 51 >#3142_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2143N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPIGQPPAAPTSLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTVQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQASDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKEGTTSNNADLEHVMIT DEEEIRTTNPVATEQYGNVSNNLQNSNTGPTTENVNNQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 52 >#1024_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1024N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDNLSEGIREWWALKPGAPQPKANQQHQDNARGLVLPGYKYLGPGNGLDKGEPVNAADAAALEHDKAYD KQLKAGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KSGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQTASGTQQSRLLFSQAGPTSMSLQAKNWLPGP CYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKEGTNATNADLDNVMITD EEEIRTTNPVATEQYGYVSNNLQNSNTAATTETVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKH PPPQIMIKNTPVPANPPTNFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYS EPRPIGTRYLTRNL* SEQ ID NO: 53 >#790_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC790N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 54 >#976_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC976N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 55 >#1286_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC1286N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 56 >#163_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC163N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPVADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKKLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO : 57 >#685_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC685N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGNRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTNANDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO : 58 >#442_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC442N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGSTTMATGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQANDNNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTGRDNADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO : 59 >#2320_AAV.FL.linear_-_major_coat_protein_VP1_translation CHC2320N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLETLGLVEEHVKTAPGKKRAVEHAHVEPDSSSGTG KAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPXGLGSTTMASGSGAPMADNNEGADGVGNSSGNWHCDSQWLGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSNSGTLQQSRLLFSQAGPTSMSLQAKNWLPG PCYRQQRLSKQATDNNNSEFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTKCNDADLDNVMIT DEEEIRTTNPVATEQYGYVSNNLQNSNTGPTTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQIMIKNTPVPANPPTNFSSAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO : 60 >#1055_AAV.linear_-_major_coat_protein_VP1_translation CHC1055N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTG KAGQQPARKRLNFGQTGPYASVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVI TTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV KEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPS QMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPG PCYRQQRVSKTAADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMIT DEEEIRTTNPVATEQYGAVSTNLQSGNTQAATSDVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLK HPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVY SEPRPIGTRYLTRNL* SEQ ID NO: 61 >#M258_AAV.linear_-_major_coat_protein_VP1_translation BCM258N_Adeno-Associated virus isolates in liver tumor, linear form MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYD RQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPAEPDSSSGTG KAGNQPARKRLNFGQTGDADSVPDPQPLGEPPAAPTSLGSTTMASGGGAPVADNNEGADGVGNSSGKLALRFPMAGRQSH YHQHPNLGPAHLQQPSVQANFQPIRSQQRQPLILAHCNPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQ VKEVTQNDGTTTIANNLTSTVQVFTDSEYQIPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFP SQMLRTGNNFQFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNKTQSASGTVQQSRLLFSQAGPTSMSLQAKNWLP GPCYRQQRLSKQANENNNSNFPWTAATKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGTLIFGKQGTGRDNADLDNVMI TDEEEIRTTNPVATEQYGYVSNNLQNSNTAPSTGTVNHQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGL KHPPPQIMIKNTPVPANPPTNFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGV YSEPRPIGTRYLTRNL* SEQ ID NO: 121 >consensus_AAV2 MAADGYLPDW LEDTLSEGIR QWWKLKPGPP PPKPAERHkD DSRGLVLPGY KYLGPFNGLD KGEPVNEADA AALEHDKAYD RQLDSGDNPY LKYNHADAEF QeRLKEDTSF GGNLGRAVFQ AKKRVLEPLG LVEEPVKTAP GKKRPVEHSP vEPDSSSGTG KaGqQPARKR LnfgQTGDAD SVPDPQPLGq PPAAPsgLGt nTMAtGsGAP mADNNEGADG VGNSSGNWHC DStWmGDRVI TTSTRTWALP TYNNHLYKQI SSQSGASNDN HYFGYSTPWG YFDFNRFHCH FSPRDWQRLI NNNWGFRPKR LNFKLFNIQV KEVTQNDGTT TIANNLTSTV QVFTDSEYQL PYVLGSAHQG ClPPFPADVF MVPQYGYLTL NNGSQAVGRS SFYCLEYFPS QMLRTGNNFT FSYTFEDVPF HSSYAHSQSL DRLMNPLIDQ YLYYLSrTNT PSGTTTqSRL QFSQAGASDI RDQSRNWLPG PCYRQQRVSK TaADNnNSeY SWTGATKYHL NGRDSLVNPG PAMASHKDDE EKfFPQSGVL IFGKQgSeKT NVDIEKVMIT DEEEIRTTNP VATEQYGsVS TNLQSGNTQA ATsDVNtQGV LPGMVWQDRD VYLQGPIWAK IPHTDGHFHP SPLMGGFGLK HPPPQIlIKN TPVPANPsTt FSaAKFASFI TQYSTGQVSV EIEWELQKEN SKRWNPEIQY TSNYNKSVNV DFTVDTNGVY SEPRPIGTRY LTRNL

A further object of the present invention relates to a variant VP2 capsid protein that consists of the amino acid sequence that ranges from the amino acid at position 138 to the last amino acid in SEQ ID NO:2 comprising at least one mutation selected from the group consisting of V151A, Q164N; T200S; N201T; M211V; T233Q; M235L; T410Q; S446N; R447K; N449Q; T450S; P451N; T455L; T456Q; Q461L; A467P; S468T; D469S; I470M; R471S; D472L; S474A; R475K; V488L; T491Q; S492A; A493N; E499N; Y500F; S501P; G504A; Q536M; S537H; V539T; S547T; E548N; K549A; T550N; N551D; V552A; I554L; E555D; K556N; S578Y; T581N; R585N; R585S; G586S; R588T; Q589G; A590P; A591T; A593S; A593G; D594T; T597H; V600A; L647M; S658P; T660N; and A663S

In some embodiments, the variant VP2 capsid protein of the present invention has an amino acid sequence that ranges from the amino acid at position 138 to the last amino acid in SEQ ID NO:3 to SEQ ID NO:61.

A further object of the present invention relates to a variant VP2 capsid protein of the present invention has an amino acid sequence that ranges from the amino acid at position 138 to the last amino acid in SEQ ID NO:26 (i.e. capsid #3013), SEQ ID NO:9 (i.e. capsid #2087), SEQ ID NO: 20 (i.e. capsid #1449), SEQ ID NO: 10 (i.e. capsid #2206), SEQ ID NO: 12 (i.e. capsid #1534), SEQ ID NO: 56 (i.e. capsid #163), SEQ ID NO: 23 (i.e. capsid #1343), SEQ ID NO: 53 (i.e. capsid #790), SEQ ID NO: 6 (i.e. capsid #1017), SEQ ID NO: 11 (i.e. capsid #877), SEQ ID NO:8 (i.e. capsid #1273), SEQ ID NO: 3 (i.e. capsid #2497), SEQ ID NO: 60 (i.e. capsid #1055), SEQ ID NO:14 (i.e. capsid #1919), SEQ ID NO: 4, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:13, SEQ ID NO:15 to SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:27 to SEQ ID NO:55, SEQ ID NO:57 to SEQ ID NO:59, SEQ ID NO:61.

A further object of the present invention relates to a variant VP3 capsid protein that consists of the amino acid sequence that ranges from the amino acid at position 203 to the last amino acid in SEQ ID NO:2 comprising at least one mutation selected from the group consisting of M211V; T233Q; M235L; T410Q; S446N; R447K; N449Q; T450S; P451N; T455L; T456Q; Q461L; A467P; S468T; D469S; I470M; R471S; D472L; S474A; R475K; V488L; T491Q; S492A; A493N; E499N; Y500F; S501P; G504A; Q536M; S537H; V539T; S547T; E548N; K549A; T550N; N551D; V552A; I554L; E555D; K556N; S578Y; T581N; R585N; R585S; G586S; R588T; Q589G; A590P; A591T; A593S; A593G; D594T; T597H; V600A; L647M; S658P; T660N; and A663S

In some embodiments, the variant VP3 capsid protein of the present invention has an amino acid sequence that ranges from the amino acid at position 203 to the last amino acid in SEQ ID NO:3 to SEQ ID NO:61.

A further object of the present invention relates to a variant VP3 capsid protein of the present invention has an amino acid sequence that ranges from the amino acid at position 203 to the last amino acid in SEQ ID NO:26 (i.e. capsid #3013), SEQ ID NO:9 (i.e. capsid #2087), SEQ ID NO: 20 (i.e. capsid #1449), SEQ ID NO: 10 (i.e. capsid #2206), SEQ ID NO: 12 (i.e. capsid #1534), SEQ ID NO: 56 (i.e. capsid #163), SEQ ID NO: 23 (i.e. capsid #1343), SEQ ID NO: 53 (i.e. capsid #790), SEQ ID NO: 6 (i.e. capsid #1017), SEQ ID NO: 11 (i.e. capsid #877), SEQ ID NO:8 (i.e. capsid #1273), SEQ ID NO: 3 (i.e. capsid #2497), SEQ ID NO: 60 (i.e. capsid #1055), SEQ ID NO:14 (i.e. capsid #1919), SEQ ID NO: 4, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:13, SEQ ID NO:15 to SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:27 to SEQ ID NO:55, SEQ ID NO:57 to SEQ ID NO:59, SEQ ID NO:61.

Polynucleotides that Encodes for the Variant Capsid Proteins:

A further object of the present invention relates to a polynucleotide that encodes for a variant capsid protein of the present invention.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP1 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2203 to the nucleotide at position 4410 in SEQ ID NO:1 and that comprises at least one mutation selected from Table 1.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP1 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2203 to the nucleotide at position 4410 in SEQ ID NO:1 and that comprises at least one mutation selected from the group consisting of 2433A>G; 2511C>T; 2654T>C; 2685G>A; 2692CAG>AAC; 2721T>C; 2745A>C; 2794C>T; 2800A>T; 2804A>C; 2808G->A; 2833A>G; 2853C>T; 2859C>T; 2877G>A; 2899AC>CA; 2905A>C; 2946C>T; 2967C>T; 2970C>G; 2976A>G; 2979A>G; 2982T>C; 3003G>A; 3012T>C; 3036T>C; 3123A>G; 3129G>A; 3165A>G; 3297C>T; 3303A>G; 3318G>C; 3360A>G; 3375A>C; 3411G>T; 3417C>T; 3430ACC>CAG; 3444T>C; 3450G>A; 3490C>T; 3495C>T; 3498T>G; 3501C>G; 3513C>G; 3534C>T; 3535T>C; 3539G>A; 3542GA>AG; 3547AAC>CAA; 3550ACT>TCA; 3553CCA>AAT; 3558T>C; 3564C>T; 3565ACC>CTT; 3568AC>CA; 3576A>C; 3576A>T; 3577A>C; 3582T>A; 3584A>T; 3589TC>AG; 3594G>A; 3597C>T3601GCG>CCC 3605GT>CC 3607GA>AG 3612T>G 3613CGG>TCT 3616GAC>CTT 3621G>A 3622T>G 3626GG>AA 3636T>G 3645C>T 3648T>C 3652CGC>AGA 3663A>T 3664GTA>CTG 3672ACA>CAG 3676TCT>GCA 3679GCG>AAC 3684T>C 3696T>C 3697GAA>AAC 3701AC>TT 3703TCG>CCC 3713GA>CG 3720C>A 3726C>T 3729C>T 3732C>A 3739AGA>CGG 3747T>G 3748C>T 3753G>T 3759G>A 3762C>A 3765G>A 3768C>T 3774A>C 3783G>A 3804T>C 3807T>C 3808CA>AT 3811AGC>CAT 3816G>A 3817GTT>ACC 3822C>G 3825C>A 3831G>A 3834G>A 3840C>A 3841T>A 3844GAG>AAT 3847AAA>GCT 3851CA>AC 3853AAT>GAC 3857T>C 3861C>T 3862ATT>TTG 3867A>C 3870>T 3885C>T 3891G>A 3898AGG>CGC 3903A>C 3930T>C 3933T>A 3935C>A 3939A>G 3942T>A 3944CC>AT 3948C>T 3949CTC>TTG 3954G>A 3956GA>AC 3957A>C 3958GGC>TCA 3963C>T 3965G>C 3967CAA>GGT 3970G>C 3973G>A 3978C>T 3979G>T 3980C>G 3982GA>AC 3990C>T 3991ACA>CAC 3999C>A 4001TT>CG 4003CTT>TTA 4008A>T 4011C>T 4017C>G 4026C>T 4027A>C 4032T>C 4041T>G 4047G>A 4053C>T 4059A>C 4068A>T 4074G>C 4077C>T 4083T>C 4089C>T 4092C>T 4098C>A 4101C>G 4107T>C 4110A>T 4113C>T 4116A>G 4119T>G 4128T>G 4134A>G 4140T>C 4141CTC>ATG 4149G>A 4155C>T 4158G>C 4161A>T 4164T>A 4167G>C 4174TCG>CCC 4179C>A 4181C>A 4189GCG>TCT 4194A>C 4206C>T 4221C>T 4230A>G 4269A>G 4287T>C 4293A>G 4296T>C 4320G>A and 4356C>T.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP1 capsid of the present invention consists the nucleic sequence that ranges from the nucleotide at position 2203 to the nucleotide at position 4410 in SEQ ID NO: 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94; 95; 96; 97; 98; 99; 100; 101; 102; 103; 104; 105; 106; 107; 108; 109; 110; 111; 112; 113; 114; 115; 116; 117; or 118.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP1 capsid of the present invention consists the nucleic sequence that ranges from the nucleotide at position 2203 to the nucleotide at position 4410 in SEQ ID NO: 85 (i.e. capsid #3013), SEQ ID NO: 68 (i.e. capsid #2087), SEQ ID NO: 79 (i.e. capsid #1449), SEQ ID NO: 69 (i.e. capsid #2206), SEQ ID NO: 71 (i.e. capsid #1534), SEQ ID NO: 115 (i.e. capsid #163), SEQ ID NO: 82 (i.e. capsid #1343), SEQ ID NO: 112 (i.e. capsid #790), SEQ ID NO:65 (i.e. capsid #1017), SEQ ID NO: 70 (i.e. capsid #877), SEQ ID NO: 67 (i.e. capsid #1273), SEQ ID NO: 62 (i.e. capsid #2497); SEQ ID NO: 119 (i.e. capsid #1055); SEQ ID NO: 73 (i.e. capsid #1919), SEQ ID NO:63, SEQ ID NO:64; SEQ ID NO:66, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO:98, SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:103, SEQ ID NO:104; SEQ ID NO:105, SEQ ID NO: 106; SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO: 110; SEQ ID NO:111, SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO:116, SEQ ID NO: 117; SEQ ID NO:118 or SEQ ID NO:120.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP2 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2614 to the nucleotide at position 4410 in SEQ ID NO:1 and that comprises at least one mutation selected from Table 1.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP2 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2614 to the nucleotide at position 4410 in SEQ ID NO:1 and that comprises at least one mutation selected from the group consisting of 2654T>C; 2685G>A; 2692CAG>AAC; 2721T>C; 2745A>C; 2794C>T; 2800A>T; 2804A>C; 2808G->A; 2833A>G; 2853C>T; 2859C>T; 2877G>A; 2899AC>CA; 2905A>C; 2946C>T; 2967C>T; 2970C>G; 2976A>G; 2979A>G; 2982T>C; 3003G>A; 3012T>C; 3036T>C; 3123A>G; 3129G>A; 3165A>G; 3297C>T; 3303A>G; 3318G>C; 3360A>G; 3375A>C; 3411G>T; 3417C>T; 3430ACC>CAG; 3444T>C; 3450G>A; 3490C>T; 3495C>T; 3498T>G; 3501C>G; 3513C>G; 3534C>T; 3535T>C; 3539G>A; 3542GA>AG; 3547AAC>CAA; 3550ACT>TCA; 3553CCA>AAT; 3558T>C; 3564C>T; 3565ACC>CTT; 3568AC>CA; 3576A>C; 3576A>T; 3577A>C; 3582T>A; 3584A>T; 3589TC>AG; 3594G>A; 3597C>T3601GCG>CCC 3605GT>CC 3607GA>AG 3612T>G 3613CGG>TCT 3616GAC>CTT 3621G>A 3622T>G 3626GG>AA 3636T>G 3645C>T 3648T>C 3652CGC>AGA 3663A>T 3664GTA>CTG 3672ACA>CAG 3676TCT>GCA 3679GCG>AAC 3684T>C 3696T>C 3697GAA>AAC 3701AC>TT 3703TCG>CCC 3713GA>CG 3720C>A 3726C>T 3729C>T 3732C>A 3739AGA>CGG 3747T>G 3748C>T 3753G>T 3759G>A 3762C>A 3765G>A 3768C>T 3774A>C 3783G>A 3804T>C 3807T>C 3808CA>AT 3811AGC>CAT 3816G>A 3817GTT>ACC 3822C>G 3825C>A 3831G>A 3834G>A 3840C>A 3841T>A 3844GAG>AAT 3847AAA>GCT 3851CA>AC 3853AAT>GAC 3857T>C 3861C>T 3862ATT>TTG 3867A>C 3870>T 3885C>T 3891G>A 3898AGG>CGC 3903A>C 3930T>C 3933T>A 3935C>A 3939A>G 3942T>A 3944CC>AT 3948C>T 3949CTC>TTG 3954G>A 3956GA>AC 3957A>C 3958GGC>TCA 3963C>T 3965G>C 3967CAA>GGT 3970G>C 3973G>A 3978C>T 3979G>T 3980C>G 3982GA>AC 3990C>T 3991ACA>CAC 3999C>A 4001TT>CG 4003CTT>TTA 4008A>T 4011C>T 4017C>G 4026C>T 4027A>C 4032T>C 4041T>G 4047G>A 4053C>T 4059A>C 4068A>T 4074G>C 4077C>T 4083T>C 4089C>T 4092C>T 4098C>A 4101C>G 4107T>C 4110A>T 4113C>T 4116A>G 4119T>G 4128T>G 4134A>G 4140T>C 4141CTC>ATG 4149G>A 4155C>T 4158G>C 4161A>T 4164T>A 4167G>C 4174TCG>CCC 4179C>A 4181C>A 4189GCG>TCT 4194A>C 4206C>T 4221C>T 4230A>G 4269A>G 4287T>C 4293A>G 4296T>C 4320G>A and 4356C>T.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP2 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2614 to the nucleotide at position 4410 in SEQ ID NO: 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94; 95; 96; 97; 98; 99; 100; 101; 102; 103; 104; 105; 106; 107; 108; 109; 110; 111; 112; 113; 114; 115; 116; 117; or 118.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP2 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2614 to the nucleotide at position 4410 in SEQ ID NO: 85 (i.e. capsid #3013), SEQ ID NO: 68 (i.e. capsid #2087), SEQ ID NO: 79 (i.e. capsid #1449), SEQ ID NO: 69 (i.e. capsid #2206), SEQ ID NO: 71 (i.e. capsid #1534), SEQ ID NO: 115 (i.e. capsid #163), SEQ ID NO: 82 (i.e. capsid #1343), SEQ ID NO: 112 (i.e. capsid #790), SEQ ID NO:65 (i.e. capsid #1017), SEQ ID NO: 70 (i.e. capsid #877), SEQ ID NO: 67 (i.e. capsid #1273), SEQ ID NO: 62 (i.e. capsid #2497); SEQ ID NO: 119 (i.e. capsid #1055); SEQ ID NO: 73 (i.e. capsid #1919), SEQ ID NO:63, SEQ ID NO:64; SEQ ID NO:66, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO:98, SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:103, SEQ ID NO:104; SEQ ID NO:105, SEQ ID NO: 106; SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO: 110; SEQ ID NO:111, SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO:116, SEQ ID NO: 117; SEQ ID NO:118 or SEQ ID NO:120

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP3 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2809 to the nucleotide at position 4410 in SEQ ID NO:1 and that comprises at least one mutation selected from Table 1.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP3 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2809 to the nucleotide at position 4410 in SEQ ID NO:1 and that comprises at least one mutation selected from the group consisting of 2833A>G; 2853C>T; 2859C>T; 2877G>A; 2899AC>CA; 2905A>C; 2946C>T; 2967C>T; 2970C>G; 2976A>G; 2979A>G; 2982T>C; 3003G>A; 3012T>C; 3036T>C; 3123A>G; 3129G>A; 3165A>G; 3297C>T; 3303A>G; 3318G>C; 3360A>G; 3375A>C; 3411G>T; 3417C>T; 3430ACC>CAG; 3444T>C; 3450G>A; 3490C>T; 3495C>T; 3498T>G; 3501C>G; 3513C>G; 3534C>T; 3535T>C; 3539G>A; 3542GA>AG; 3547AAC>CAA; 3550ACT>TCA; 3553CCA>AAT; 3558T>C; 3564C>T; 3565ACC>CTT; 3568AC>CA; 3576A>C; 3576A>T; 3577A>C; 3582T>A; 3584A>T; 3589TC>AG; 3594G>A; 3597C>T3601GCG>CCC 3605GT>CC 3607GA>AG 3612T>G 3613CGG>TCT 3616GAC>CTT 3621G>A 3622T>G 3626GG>AA 3636T>G 3645C>T 3648T>C 3652CGC>AGA 3663A>T 3664GTA>CTG 3672ACA>CAG 3676TCT>GCA 3679GCG>AAC 3684T>C 3696T>C 3697GAA>AAC 3701AC>TT 3703TCG>CCC 3713GA>CG 3720C>A 3726C>T 3729C>T 3732C>A 3739AGA>CGG 3747T>G 3748C>T 3753G>T 3759G>A 3762C>A 3765G>A 3768C>T 3774A>C 3783G>A 3804T>C 3807T>C 3808CA>AT 3811AGC>CAT 3816G>A 3817GTT>ACC 3822C>G 3825C>A 3831G>A 3834G>A 3840C>A 3841T>A 3844GAG>AAT 3847AAA>GCT 3851CA>AC 3853AAT>GAC 3857T>C 3861C>T 3862ATT>TTG 3867A>C 3870>T 3885C>T 3891G>A 3898AGG>CGC 3903A>C 3930T>C 3933T>A 3935C>A 3939A>G 3942T>A 3944CC>AT 3948C>T 3949CTC>TTG 3954G>A 3956GA>AC 3957A>C 3958GGC>TCA 3963C>T 3965G>C 3967CAA>GGT 3970G>C 3973G>A 3978C>T 3979G>T 3980C>G 3982GA>AC 3990C>T 3991ACA>CAC 3999C>A 4001TT>CG 4003CTT>TTA 4008A>T 4011C>T 4017C>G 4026C>T 4027A>C 4032T>C 4041T>G 4047G>A 4053C>T 4059A>C 4068A>T 4074G>C 4077C>T 4083T>C 4089C>T 4092C>T 4098C>A 4101C>G 4107T>C 4110A>T 4113C>T 4116A>G 4119T>G 4128T>G 4134A>G 4140T>C 4141CTC>ATG 4149G>A 4155C>T 4158G>C 4161A>T 4164T>A 4167G>C 4174TCG>CCC 4179C>A 4181C>A 4189GCG>TCT 4194A>C 4206C>T 4221C>T 4230A>G 4269A>G 4287T>C 4293A>G 4296T>C 4320G>A and 4356C>T.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP3 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2809 to the nucleotide at position 4410 in SEQ ID NO: 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94; 95; 96; 97; 98; 99; 100; 101; 102; 103; 104; 105; 106; 107; 108; 109; 110; 111; 112; 113; 114; 115; 116; 117; or 118.

In some embodiments, the polynucleotide of the present invention that encodes for a variant VP3 capsid of the present invention consists of the nucleic sequence that ranges from the nucleotide at position 2809 to the nucleotide at position 4410 in SEQ ID NO: 112, SEQ ID NO: 115, SEQ ID NO: 101, SEQ ID NO:105, SEQ ID NO: 111, SEQ ID NO:98, SEQ ID NO:107, SEQ ID NO:109, SEQ ID NO:108, SEQ ID NO:103, SEQ ID NO:116, SEQ ID NO: 62; SEQ ID NO:63; SEQ ID NO:64; SEQ ID NO:65; SEQ ID NO:66; SEQ ID NO:67; SEQ ID NO:68; SEQ ID NO:69; SEQ ID NO:70; SEQ ID NO:71; SEQ ID NO:72; SEQ ID NO:73; SEQ ID NO:74; SEQ ID NO:75; SEQ ID NO:76; SEQ ID NO:77; SEQ ID NO:78; SEQ ID NO:79; SEQ ID NO:80; SEQ ID NO:81; SEQ ID NO:82; SEQ ID NO:83; SEQ ID NO:84; SEQ ID NO:85; SEQ ID NO:86; SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:104; SEQ ID NO: 106; SEQ ID NO: 110; SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO: 117; SEQ ID NO:118, SEQ ID NO:119 or SEQ ID NO:120 SEQ ID NO: 85 (i.e. capsid #3013), SEQ ID NO: 68 (i.e. capsid #2087), SEQ ID NO: 79 (i.e. capsid #1449), SEQ ID NO: 69 (i.e. capsid #2206), SEQ ID NO: 71 (i.e. capsid #1534), SEQ ID NO: 115 (i.e. capsid #163), SEQ ID NO: 82 (i.e. capsid #1343), SEQ ID NO: 112 (i.e. capsid #790), SEQ ID NO:65 (i.e. capsid #1017), SEQ ID NO: 70 (i.e. capsid #877), SEQ ID NO: 67 (i.e. capsid #1273), SEQ ID NO: 62 (i.e. capsid #2497); SEQ ID NO: 119 (i.e. capsid #1055); SEQ ID NO: 73 (i.e. capsid #1919), SEQ ID NO:63, SEQ ID NO:64; SEQ ID NO:66, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO:98, SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:103, SEQ ID NO:104; SEQ ID NO:105, SEQ ID NO: 106; SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO: 110; SEQ ID NO:111, SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO:116, SEQ ID NO: 117; SEQ ID NO:118 or SEQ ID NO:120.

SEQ ID NO: 62 >#2497_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTASCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCAAATTCTGACGSRC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGAYA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGAYCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATTTTGGAACTAAACGGGTACGACCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAGGATGACCGCCAAGGTCGTGGAGTCGACCAAAGCCATTC TTGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACAAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTYAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAARGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAACACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCATTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCAGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATTTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTTTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCMTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCAAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAGCAACAGTGAGTACTCGTGGACTGGTGCTACC AAGTACCACCTCAATGGAAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCACAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTACTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCATTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGACCCATCTGGGCAAAGATTCCACACACGGACGGA CACTTTCACCCTTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATCACACAGTACTCCACGGGACAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAAAACAGCAAACGCTGGAATCCCGAAATCCAGTACACTTCCAACTACAACAAR TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTATTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 63 >#2102_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACATCAT GTGGTCACGCTTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGG AGGTTTGAACGTGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGC GACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAG GAATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTG ACCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCC CCGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTG CTTGTGGAGACCACAGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGC GAAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCG GTCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATC CCCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTTCAGTGGGCGTGGACTAATATGGAA CAGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTG ACGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCG CCGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGAT AAGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTC AATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATC ATGAGCCTCACTAAAACCGCCCCMGACTACCTRGTGGGCCAGCAGCCCGTGGAGGACATT TCCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCT TCCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTT GGGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTC TACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATG GTGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATT CTCGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCG ACTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACG ACCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGT CTGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCA AAGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAA AGRCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCG CAGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAA TGTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATG AATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCC GTGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATT CATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGAT TTGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTA TCTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAA ACCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATCAGGACGACAGCAGGGGTCTTGT GCTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAAGGAGAGCCGGTCAA CGAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGAAAGCGG AGACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGA AGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCT TGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGT AGAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCAACCAGCC TGCAAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCA ACCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGG CAGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGG AAATTGGCATTGCGATTCCACATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGCAC CTGGGCTCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGC CTCGAACGACAATCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAG ATTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATT CCGGCCCAAAAGACTCAACTTCAAGCTGTTTAACATTCAAGTCAAAGAGGTCACGCAGAA TGACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTC GGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCC AGCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGC GGTCGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAAATGCTTCGTACCGG AAACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCA CAGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAG CGGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGG AGCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCA GCGAGTATCAAAGACAGCTGCGGACAACAGCAACAGTGAGTACTCGTGGACTGGAGCTAC CAAGTACCACCTCAATGGAAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCA CAAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGG CTCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAG GACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGG CAACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTG GCAGGACAGAGACGTGTACCTGCAGGGGCCTATCTGGGCAAAGATTCCACACACGGACGG ACATTTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGAT TCTCATCAAAAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTT TGCTTCCTTCATCACACAGTACTCCACGGGACAGGTCAGCGTGGAGATCGAGTGGGAGCT GCAGAAGGAAAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAA ATCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCAT TGGCACCAGATACCTGACTCTTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATT CGTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 64 >#371_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGAC CGACGCCCGGGCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCGGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACTGGGGTTAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATAAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAATCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAAAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAACAGATTTCCAGCCAATCAGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTATTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAA CGAGTATCAAAGACATCTGCGGATAACAACAACAGTGAATATTCGTGGACTGGAGCTACC AAATACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGAAAACAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACAGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCTGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTCGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATTACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAATGGGAGCTG CAGAAAGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTTATTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 65 >#1017_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAGACTACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATTTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACAAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCTTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTTCAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCATCTCTACAAGCAGATTTCCAGCCAATCAGGAGCT TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTCTCGCCACGTGACTGGCAGAGACTCATCAACAACAACTGGGGATTC CGTCCCAAGAGACTCAACTTCAAGCTGTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGTTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAAACATCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGAAAACAAGAC TCAGGAAAAACTAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACGCACAAGGTGTTCTTCCAGGCATGGTCTGG CAGGACAGAGAYGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCWCACACGGAYGGA CAYTTTCACCCCTCTCCCCTCATGGGCGGATTCGGACTGAAACACCCTCCTCCACAAATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCAACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATYACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAAAACAGCAAACGCTGGAATCCCGAAATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTATTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGGTCGCCCGACGC CCGGGCGTCGGGCGACCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 66 >#473_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCGCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGATGGGTGGAGTCGTGACGTAAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGTCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAAAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCAATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGAAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACAAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTACCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCAAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTGGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGAAAACAAGAC TCAGGAAAAACTAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACGCACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCCCCGCAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTTATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTATTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 67 >#1273_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCAAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTATATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGATCAGGCTTCATACATCTCCTTCA ATGCGGCCTCTAACTCGCGATCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCATCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATTTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATCAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGATCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAGAGATTGCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAGCCTCTCGGA CAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGCAGTGGCGCA CCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGAAATTGGCAT TGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACCTGGGCTCTG CCCACCTACAACAACCATCTGTACAAGCAGATATCCAGCCAGTCTGGAGCCAGCAACGAC AACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGATTCCACTGC CACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTCCGGCCAAAA AGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAATGACGGTACG ACAACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGGAGTACCAG CTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCAGCAGACGTC TTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCAGTAGGACGC TCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGAAACAACTTT ACCTTCAGCTACACTTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCACAGCCAGAGT TTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGCAGAACAAAC ACTCCAAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGAGCGAGTGAC ATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAGCGAGTATCA AAGACAGCTGCGGACAACAACAACAGTGAATACTCGTGGACTGGAGCTACCAAGTACCAC CTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCACAAGGACGAT GAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGAAAACAAGACTCGGGAAAA ACTAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGGACCACCAAT CCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGCAACACACAA GCAGCTACCTCAGATGTCAACGCACAAGGTGTTCTTCCAGGCATGGTCTGGCAGGACAGA GACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGACATTTTCAC CCCTCTCCCCTCATGGGCGGATTCGGACTTAAACACCCTCCTCCACAAATTCTCATCAAG AACACCCCTGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTTGCTTCCTTC ATTACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTGCAGAAAGAG AACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAATCTGTTAAT GTGGACTTTACTGTAGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATTGGCACCAGA TACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTT GAACTTTGGTCTCTGCGTACTTATTTCTTATCTGGTTTCCATGGCTACGTAGATAAGTAG CATGGCGGGTTAATCATTAAATCTAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCT CTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGCCCGGGCTTT GCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 68 >#2087_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACGCCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCAGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGATCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCTCAAATCAAGGCTGCCTTGGACAATGCGGGAAAGATTA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT TCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCTGCTT CCGTCTTTCTGGGATGGGCCACAAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTACCCTTCT ACGGGTGTGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGCGGAAGCAAGGTGCGCGTGGACCAAAAATGCAAGTCCTCGGCCCAGATCGACCCGA CTCCCGTGATCGTCACTTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTTTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACAGGAAAAGCGGGCAACCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTTCAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCATCTCTACAAGCAGATTTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAAAGACTCAACTTCAAGCTTTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTTGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAAATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAACAACAGTGAGTACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGAAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGTGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGATTGAAGCACCCTCCCCCGCAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCAGCAAAGTTT GCTTCCTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTATAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTATTTTTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGAGGGTTAATCATTATCTATAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 69 >#2206_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTTGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGTATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTTGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAAATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACTTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTGCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTTGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAACCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTTCAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCATCTCTACAAGCAGATTTCCAGCCAATCAGGAGCT TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTCTCGCCACGTGACTGGCAGAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACGCCAAGCGGAACCACCACGCAGTCCAGACTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACATCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGAAAACAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACAGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGATTAAAGCACCCTCCCCCGCAAATT CTCATTAAGAATACCCCGGTACCTGCAAATCCTTCTACCACTTTCAGCGCGGCAAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAATACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGTGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTACCATGGATGGTTAATCATTAACTATAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 70 >#877_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGTCCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGCCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATTTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACTACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCTGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCAGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCTATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTTGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCACATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCAATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCAAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCAACCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTGCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCTATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGACTGAAGCACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCTACCACTTTCAGTGCGGCAAAATTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCAAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTACCATGGAGGGTTAATCATTAACACAAGGAACCCCTAGTGATGGAGTTGGCCA CTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGCC CGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 71 >#1534_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGG CGTCGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTACGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAAAGCTACTTCCACATGCACGTGC TCGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AAGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAAATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTATTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATCAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAACCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATATCCAGCCAGTCTGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCAAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACAACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTGCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGATAACAACAACAGTGAATATTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGATGTGTACCTGCAGGGGCCTATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCAAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTA CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTAAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTACCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGACTGAAACGAATTAA SEQ ID NO: 72 >#2557_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCSATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTACCCGGCATTTCTGACAGCTTTGTGAACTGGGTAGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGYGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACAACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATCTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC GGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGRTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGAGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGGAAGATTA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTCTTGGGATGGGCTACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTTCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAAGTGCGTGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTCCCGTGGCCACCAAGCAGGAAGTCAAAGATTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATYC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAACACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCCAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCAGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAACCAGCCT GCAAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAGATTTCCAGCCAGTCTGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCAAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTGCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTATGG CAGGACAGAGACGTGTACCTGCAGGGGCCTATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCAAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGTGTGGAGATTGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTACAACAAR TCTGTTAATGCGGACCTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTGCTTCTTTCTTATCTAGTTTACATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 73 >#1919_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGCCCTT TCCCCCACACCCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATCAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTTGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTAATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTTGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCGTACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCGCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTTTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAAAACTTTCCATTCAATGACTGTGTTGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACTTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCATATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGATGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCAACCAGCCT GCAAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAGTCTGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCAGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTCGGACTGAAGCACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTATAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGAGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCG GGCGAGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 74 >#1260_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAAAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAACCTGAACTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAAAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAAGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCTGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAATGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAAAAGTGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCGCCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAAAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTCAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACGGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAGTCTGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTATATTACTTAAGC AGAACAAACACGCCGAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACATCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATATTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACGCACAAGGTGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCCCACACGGACGGA CACTTTCACCCTTCTCCTCTTATGGGCGGATTCGGACTTAAACACCCTCCCCCGCAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGCGCGGCAAAGTTT GCTTCCTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTAGAAATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTATAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACACAAGGAACCCCTAGTGATGGAGTTGGCCA CTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCGGG CGACCTTTGGTCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 75 >#3765_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTAAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCAGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGATCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATTA TGAGCCTGACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCTGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAAGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTGAAAGACTTTTTCCGGTGGGCAA ATGATCACGTGGTCGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATTATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAACCAGCCT GCAAGAAAAAGACTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATCGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTTCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAAGCA GTAGGACGCTCTTCATTTTACTGCCTGGAATACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTATACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGCCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACACCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCACACACGGATGGA CACTTTCACCCTTCTCCTCTTATGGGAGGATTTGGACTTAAACACCCTCCCCCGCAGATT CTCATCAAAAACACCCCGGTACCTGCGAATCCTTCGACCACTTTCAGTGCAGCAAAGTTT GCTTCCTTCATTACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTTTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 76 >#471_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTATATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACATCAT GTGGTCACGCTAGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTTCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACAGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCAAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCTGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCCTACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCACAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATTA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCGGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACAAACATCGCGGAGGCCATAGCCCACACGGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TTGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCTGTGATTGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAACAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCTACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAATACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAACACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAACCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCAAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTAAACAACGGGAGTCAAGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTATACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGCCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACACCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATTTGGGCAAAAATTCCACACACGGATGGA CACTTTCACCCTTCTCCTCTTATGGGAGGATTTGGACTTAAACACCCTCCCCCGCAGATT CTCATCAAAAACACCCCGGTACCTGCGAATCCTTCAACCACCTTCAGTGCAGCAAAGTTT GCTTCCTTCATTACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAATACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGTCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACACAAGGAACCCCTAGTGATGGAGTTGGCCA CTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCGGG CGACCTTTGGTCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 77 >#387_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGCTTTGCGACATTTTGCGACACTAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATCGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAATTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CCGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAGACCACGGGGGTCAAATCCATGGTTTTGGGACGTTTCCTGAGTCAAATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAACCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACCCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACATCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATTCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GACCTGCAACTACCGGGAAGACCAACATCGCAGAGGCCATAGCCCACACGGTTCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATAGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCCACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTTACCCGCCGTC TGGATCATGACTTTGGAAAGGTCACCAAGCAGGAAGTGAAAGACTTTTTCCGGTGGGCAC AGGATAACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGATTCCTCCTCCGGAACTGGAAAGTCGGGCAACCAGCCT GCAAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCATCTCTACAAGCAGATTTCCAGCCAGTCTGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATTC CGGCCCAAAAGACTCAACTTCAAGCTGTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTAGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACACCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGTAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAAGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCTATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTCGGACTTAAACACCCTCCTCCGCAAATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGTTG CAGAAGGAGAACAGCAAACGCTGGAACCCTGAGATCCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGTTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTATTTCTTATCTAGTTGCCATGGCTACGTA AATAAGTAGCATGGCGGGTTAATCATAAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 78 >#2040_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGTCACCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATTTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TTACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGATACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTTGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCGTGCAAAACCTGCGAGAGAATGA ATCAGATTTCAAATATCTGTTTCACGCACGGTATCAAAGACTGTGGGGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGAAGACTTATCAGAAACTGTGTCCAA TTCATCACATTTTGGGAAGAGCACCCGAGATTGCGTGTTCGGCCTGCGATCTGGCCAATG TAGACTTGGATGACTGTGTTTCTGAACAATAAATGACTTAAACCAGGTATGGCTGCCGAT GGTTATCTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAG CTCAAACCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGT CTTGTGCTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCG GTCAACGAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGAC AGCGGAGACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTT AAAGAAGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGG GTTCTTGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGG CCGGTAGAGCACTCTCCTGTGGAACCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAG CAGCCTGCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGAC CCCCAGCCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTACTACGATGGCT ACAGGCAGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCC TCGGGAAATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACC CGAACCTGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCA GGAGCCTCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTC AACAGATTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGG GGATTCCGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACG CAGAATGACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACT GACTCGGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCG TTCCCAGCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGT CAAGCAGTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGT ACCGGAAACAACTTTACCTTCAGCTATACCTTTGAGGACGTTCCTTTCCACAGCAGCTAC GCTCACAGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTAC TTGAGCAGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAG GCCGGAGCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGC CAGCAGCGAGTATCAAAGACAGCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGA GCTACCAAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCC AGCCACAAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAG CAAGGCTCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAA ATCAGGACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAG AGCGGCAACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATG GTCTGGCAGGACAGAGACGTGTACCTTCAGGGGCCCATCTGGGCAAAGATTCCACACACG GACGGACATTTTCACCCCTCTCCCCTCATGGGCGGATTCGGACTTAAACACCCTCCTCCG CAAATTCTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCA AAGTTTGCTTCCTTCATCACACAGTATTCCACGGGACAGGTCAGCGTGGAGATCGAGTGG GAGTTGCAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTAC AACAAATCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGC CCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTT TAATTCGTTTCATTTGAACTTTGGTCTCTGCGTACTTCTTTTCTTATCTAGTTTCCATGG CTACGTAAATAAGTACCATGGCGGGTTAATCATTAACTTTAAGGAACCCCTAGTGATGGA GTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGC CCGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGT GGCCAA SEQ ID NO: 79 >#1449_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGGAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGCGACTTTCTGACAGAATGGCGCCGTGTGAGTAAGGCCC CCGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAAAGCTACTTCCACATGCACGTGC TTGTGGAAACCACGGGGGTGAAGTCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACCCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGATACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCCGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCGGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTATGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTGCCCTTCT ACGGGTGCGTAAACTGGACCAACGAGAACTTTCCTTTCAATGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTTGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTTACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACAAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCGTGCAAAACCTGCGAGAGAATGA ATCAGATTTCAAATGTCTGTTTCACGCACGGTGTCAAAGACTGTGGGGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGAAGACTTATCAGAAACTGTGTCCAA TTCATCACATTTTGGGAAGAGCACCCGAGATTGCGTGTTCGGCCTGCGATCTGGCCAATG TGGATTTGGATGACTGTGTTTCTGAACAATAAATGACTTAAACCAGGTATGGCTGCCGAT GGTTATCTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAG CTCAAACCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAACAGGGGT CTTGTGCTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCG GTCAACGAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGAC AGCGGAGACAATCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTT AAAGAAGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGG GTTCTTGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAAACGGCTCCGGGAAAAAAGAGG CCGGTAGAGCACTCTCCTGTGGAGCCAGACTCCTCCTCCGGAACTGGAAAGTCGGGCCAA CAGCCTGCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGAC CCCCAGCCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCT ACAGGCAGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCC TCGGGAAATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACC CGAACCTGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCA GGAGCCTCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTC AACAGATTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGG GGATTCCGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACG CAGAATGACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACT GACTCGGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCG TTCCCAGCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTAAACAACGGGAGT CAAGCAGTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGT ACCGGAAACAACTTTACCTTCAGCTATACCTTTGAGGACGTTCCTTTCCACAGCAGCTAC GCTCACAGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTAC TTGAGCAGAACAAACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAA GCCGGAGCAAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGC CAGCAGCGAGTATCAAAGACACCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGA GCTACCAAGTACCACCTCAATGGCAGAGACTCTCTGGTAAATCCGGGCCCGGCCATGGCC AGCCACAAGGACGATGAAGAGAAGTTTTTCCCTCAAAGCGGGGTTCTCATCTTTGGGAAG CAAGGCTCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAA ATCAGGACCACCAATCCCGTGGCTACGGAGCAGTATGGTACTGTATCTACCAACCTCCAG AGCGGCAACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCATTCTTCCAGGCATG GTCTGGCAGGACAGAGACGTGTACCTGCAGGGACCCATTTGGGCAAAGATTCCACACACG GACGGACATTTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCA CAGATTCTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCA AAGTTTGCTTCCTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGG GAGCTGCAGAAAGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAATTAC AACAAATCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGC CCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTT TAATTCGTCTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGC TACGTAGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAG TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAA SEQ ID NO: 80 >#2128_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCAGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAACTCCAGTGGACTAATATGGAACAGTATT TAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGACGCACG TGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGCCGGTGA TTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATAAGGGGA TTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCAATGCGG CCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCATGAGCC TGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTTCCAGCA ATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTTCCGTCT TTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTGGGCCTG CAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTGCCCTTCTACGGGT GCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGGTGATCT GGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTCTCGGAG GAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGACTCCCG TGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGACCTTCG AACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGCCTGGATC ATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAAAGGATC ACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAAGGCCCG CCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGCAGCCAT CGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAATGTTCTC GTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGAATCAAA ATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCGTGTCAG AATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTCATCATA TCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATTTGGATG ACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTATCTTCCA GATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAACCTGGC CCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTGCTTCCT GGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAACGAGGCA GACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGAGACAAC CCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAAGATACG TCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTTGAACCT CTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTAGAGCAC TCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCAACCAGCCTGCAAGA AAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAACCTCTC GGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGCAGTGGC GCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGAAATTGG CATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACCTGGGCT CTGCCCACCTACAACAACCATCTCTACAAGCAGATTTCCAGCCAGTCTGGAGCCTCAAAC GACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGATTCCAC TGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTCCGACCC AAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAATGACGGT ACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGGAGTAC CAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCAGCAGAC GTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGAAGTCAGGCAGTAGGA CGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAAATGCTGCGTACCGGAAACAAC TTTACCTTCAGCTACACATTTGAAGACGTGCCTTTCCACAGCAGCTACGCTCACAGCCAG AGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGCAGAACA AACACTCCAAGCGGAACCACCACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGAGCAAGT GACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAGCGAGTA TCAAAGACATCTGCAGATAACAACAATAGTGAATACTCGTGGACTGGAGCTACCAAGTAC CACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCACAAGGAC GATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGAAAGCAAGGTTCAGAG AAAACAAATGTGGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGGACCACCAATCCC GTGGCTACGGAGCAGTATGGTGCTGTATCTACCAACCTCCAGAGCGGCAACACACAAGCA GCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGGCAGGACAGAGAC GTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCCCACACGGATGGACACTTTCACCCT TCTCCTCTTATGGGAGGATTTGGACTTAAACACCCTCCCCCGCAGATTCTCATCAAGAAC ACCCCGGTACCTGCGAATCCTTCGACCACCTTTAGTGCGGCAAAGTTTGCTTCCTTCATC ACACAGTATTCCACGGGGCAGGTCAGTGTGGAGATCGAGTGGGAGCTGCAGAAGGAGAAC AGCAAGCGCTGGAACCCCGAGATCCAATACACTTCCAACTACAACAAATCTGTTAATGTG GACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTGGCACCAGATAC CTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAATTGAA CTTTGGTCTCTGCGTACTTCTTTCTTATATAGTTTCCATGGCTACGTAGATAAGTAGCAT GGCGGGTTAATCATTAACACAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCTCTGC GCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGCCCGGGCTTTGCCC GGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 81 >#2141_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGGGCAAAGTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCAGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGATACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAAGTTGTGGATGAGTGCTACATCC CCGATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCTAATTCTGACGCGC CGGTGATCAGATCAAAACCCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCCTACATCTCCTTCA ATGCGGCCTCCACCTCGCGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGGAAGATCA TGAGCCTGACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTTGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGTAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCTGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTATCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTACCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCAACCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAACAAATTTCCAGCCAATCAGGAGCC TCGAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTATACCTTTGAGGATGTTCCGTTCACAAGCAGATACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGTGGAACCACCACGCAGTCAAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGATCAGTCTAGGAACTGGCTTCCTGGACCCTGTTATCGCCAGCAG CGAGTATCAAAGACATCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGTCAC AAAGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGGAGAGGAAATCAGG ACCACCAATCCCGTCGCCACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGAGGC AACACACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCTATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGACTTAAACACCCTCCCCCGCAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTTATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTACCATGGCGGGTTAATCATTAACTATAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 82 >#1343_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTGGCTCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GATTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATTTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAAAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAAAGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGATACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTATTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCTATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAAATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAAAATTCAAATATTTGTTTCACTCACGGACAGAAAGACTGTTTGGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTATATTC ATCATATCATGGGAAAGGTACCAGACGCTTGCACTGCTTGCGACCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGGGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGAAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCGAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCA TCGAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCATTTCTCCCCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGGCTGATGAATCCTCTGATCGACCAGTATCTGTATTACTTGAGC AAAACAAACGCTCCAAGCGGAACCACCACGATGTCCAGGCTTCAGTTTTCTCAGGCAGGA GCAAGTGACATTCGGGACCAGTCTAGAAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAACAACAGTGATTACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGAAGAGACTCTCTGGTGAATCCGGGCACAGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTATTTTCCTCAGAGCGGGGTTCTCATCTTCGGAAAACAAGAT TCGGGAAAAACTAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAAAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGACCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCTTCTCCTCTTATGGGAGGATTTGGACTGAAGCACCCCCCCCCGCAGATT CTCATCAAGAATACCCCGGTACCTGCGAATCCTTCTACCACCTTCAGCGCGGCAAAGTTT GCTTCCTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAAGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCCTGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 83 >#777_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATATAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTAAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCTC CGGAAGCCCTTTTCTTTGTGCAATTTGAGAAAGGGGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAATCCATGGTCTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAATTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTATATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTTTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACCGCCCCCGACTACCTGGTGGGCCAACAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTATGATCCCCAATATGCGGCTT CCGTCTTCCTGGGATGGGCCACGAAAAGGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCGACTACCGGGAAGACCAACATCGCGGAGGCTATAGCCCACACTGTGCCTTTTT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCGTTCAACGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAGGCCATCC TCGGTGGGAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCTGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTTAAAGACTTTTTCCGGTGGGCCC AAGACCACGTGGTAGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAAAAAGACTGCCTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTATATTC ATCATATCATGGGAAAGGTACCAGATGCTTGCACTGCTTGCGACCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCACAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAAGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCGAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCA TCGAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTCTCCCCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATTC CGGCCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGGCTGATGAATCCTCTGATCGACCAGTATCTGTATTACTTGAGC AAAACAAACGCTCCAAGCGGAACCACCACGATGTCTAGGCTTCAGTTTTCTCAGGCCGGA GCAAGTGACATTCGGGACCAGTCTAGAAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAACAACAGTGATTACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGAAGAGACTCTCTGGTGAATCCGGGCACAGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTATTTTCCTCAGAGCGGGGTTCTCATCTTCGGAAAACAAGAC TCGGGAAAAACTAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAAAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTTCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCAAAGATTCCCCACACGGATGGA CACTTTCACCCTTCCCCGCTCATGGGAGGATTTGGACTTAAACACCCTCCCCCGCAGATT CTCATCAAGAATACCCCCGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAAGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCCTGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGAGCGAGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 84 >#3511_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCGGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAGTCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCTTGGACAATGCGGGAAAAATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTTCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAAATGACCGCCAAGGTCGTGGAATCGGCCAAAGCCATTC TCGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAATCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGAAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATTTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCGAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATATGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCACAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGATTCCTCCTCCGGAACTGGAAAGTCGGGCCAACAGCCT GCAAGAAAGAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGCACC TGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAGTCTGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTCTCCCCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAGAGACTCAGCTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACCACGATGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGACAACAACAACAGTGATTACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCCGGGACTCTCTGGTGAATCCAGGACCAGCCATGGCCAGCCAC AAAGACGATGAAGAAAAGTATTTTCCTCAGAGCGGGGTTCTCATCTTTGGAAAACAAGAC TCGGGAAAAACTAATGTGGACATTGAAAAGGTTATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCTGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGACCCATCTGGGCAAAGATTCCACACACGGACGGA CACTTTCACCCTTCTCCCCTCATGGGCGGATTTGGACTGAAGCACCCTCCCCCGCAGATT CTCATCAAGAATACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATAGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTATACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTAAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGAGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCGG GCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 85 >#3013_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGAG GTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCGA CCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGGA ATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGAC CGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCCC GGAGGCTCTTTTCTTTGCGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGCT GGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCGA AAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGGT CACAAAGACCAGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCCC CAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAACA GTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGAC GCACGTGTCGCAGACGCAGGAGCAGAATAAAGAGAATCAGAATCCTAATTCTGACGCGCC GGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATAA GGGGATCACCTCCGAGAAGCAGTGGATCCAGGAGGACCAGTCTTCATACATCTCCTTCAA TGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGGAAGATCAT GAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTTC CGAAAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTTC CGTATTCCTGGGATGGGCTACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTGG GCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTTCCCTTCTA CGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGCGTCGACAAGATGGT GATCTGGTGGGAGGAGGGAAAAATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTCT CGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCTAC TCCTGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGAC CTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTCT GGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTTCGGTGGGCCCA AGACCACGTGGTAGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAAG GCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGCA GCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAATG TTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGAA TCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGACTGCTTTCCCGT GTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGTCGTATCAGAAACTTTGCTACATTCA TCATATCATGGGAAAGGTACCAGACGCTTGCAGTGCTTGCGACCTGGTCAATGTGGATTT GGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTATC TTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAAC CTGGCCCACCACCACCAAAGCCCGCAGAGCGGCACAAGGACGACAGTAGGGGTCTTGTGC TTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAAGGAGAGCCGGTCAACG AGGCAGACGCCGCGGCCCTCGAACACGACAAGGCCTACGACCGGCAGCTCGACAGCGGAG ACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAAG ATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTTG AACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTAG AGCATTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCCAGCAGCCTG CGAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAGC CTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGCA GTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGAA ATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACCT GGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAGATTTCCAGCCAATCAGGAGCAT CGAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGAT TCCACTGCCACTTCTCCCCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTCC GACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAATG ACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGG AGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCAG CAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCGG TAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGAA ACAACTTTACCTTCAGCTACACCTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCACA GCCAGAGTTTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGCA GAACAAACACTCCAAGCGGAACCACCACGATGTCCAGGCTTCAGTTTTCTCAGGCCGGAG CGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAGC GAGTATCAAAGACAGCTGCGGACAACAACAACAGTGATTACTCGTGGACTGGAGCTACCA AGTACCACCTCAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCCATGGCCAGCCACA AAGACGATGAAGAAAAGTATTTTCCTCAGAGCGGGGTTCTCATCTTCGGAAAACAAGACT CGGGAAAAACTAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGGA CCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTTCAAAGCGGCA ACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCTGGCATGGTCTGGC AGGACAGAGACGTGTACCTGCAGGGACCCATCTGGGCAAAGATTCCACACACGGACGGAC ACTTTCACCCTTCTCCCCTCATGGGCGGATTTGGACTGAAGCACCCTCCCCCGCAGATTC TCATCAAGAATACCCCGGTACCTGCGAATCCTTCTACCACCTTCAGCGCGGCAAAGTTTG CTTCCTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTGC AGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAAT CTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTG GCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCG TTTCAGTTGAACTTCAGTCTCCGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTAG ATAAGTAGCATGGCGGGTTAATCATTAACTTTAAGGAACCCCTAGTGATGGAGTTGGCCA CTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGCAAAGCCCGGGCGTCGGGC GACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 86 >#2208_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGTTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAGGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCTCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAATGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATTGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCAAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTATCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGCTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCTGAGCCAGATTCCTCCTCCGGAACTGGAAAGTCGGGCCAACAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCAGACCCTCAA CCTCTCGGAGAACCACCAGCAGCCCCCACAAGTTTGGGATCTACTACAATGGCTTCAGGC GGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATTC CGGCCCAAAAGACTCAACTTCAAGCTGTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCCCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGTCAAAGTCTGGACCGTCTCATGAATCCTCTCATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGCGGAACCACTACGCAGTCCAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACAGCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGCGGC AACACACAAGCAGCTACCTCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCCTTCATTACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAGCGCTGGAACCCTGAGATCCAGTACACTTCCAACTATAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGGTTCCATGGCTACGT AGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCGCTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 87 >#129_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGGGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGTAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGCAACCACCGGGGTTTAAATCCATGGTTTTGGGACGTTTCCTGAGTCAAATTCGCG AAAAACTGATTCAAAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTCAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCTCAAATCAAGGCTGCTCTGGACAATGCGGGGAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATCTATAAAATATTGGAACTGAACGGGTACGACCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCTTTTT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCGTTCAACGATTGCGTCGACAAGATGG TGATTTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGAAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCTTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATCAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAAGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCACAAGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTTTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACTTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGTCTGATGAATCCTCTCATCGACCAGTACCTGTATTATCTAAAC AGAACACAAACARCCAGTGGAACTCCCACGCAGTCTCGGCTACTGTTTAGCCAAGCTGGA CCCACAAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCGTGTTATCGCCAGCAG CGTTTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTTTGGTGAACCCGGGCCCGGCCATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTAATCTTTGGGAAGCAAGGC TCAGAGAAAACCAACGCGGAATTGGAAAATGTCATGATTACAGATGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACAGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGAGGC AACAGACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGATGTGTACCTTCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTT GCTTCCTTCATCACACAGTATTCCACGGGACAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGGCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAAATCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 88 >#2731_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGTGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACTTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCACGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGATGCGC CGGTGATCAGATCAAAAACTTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGTCCTCCAACTCGCGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAGGAGGATGTCCTCCAGCTTGGGCAACGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACTGCCAAGGTCGTGGAGTCTGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACTAGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATTATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACGTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GCAGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAG GAAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGATTGGCATTGCGACCCCCAGCCT CTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGCAGT GGCGCACTATTATTATTGGAAAGCTTGAGTGCCGATGGAGTGGGTAATTCCTCAGGAAAT TGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACCTGG GCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCCTCA AACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGATTC CACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTCCGA CCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAATGAC GGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGGAG TACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCAGCG GACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCAGTA GGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGAAAC AACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCACAGC CAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAACAAA ACACAATCAAATAGTGGAACCACCACGATGTCAAGGCTACTGTTTAGTCAAGCTGGACCC ACCAGCATGTCTCTTCACGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAGCGT CTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCAGCTACAAAG TATCATCTAAATGGCAGTGACTCGTTGATTAATCCAGGACCAGCTATGGCCAGCCACAAA GACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGCTCA GAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGGACA ACCAATCCCGTGGCTACGGAGCAGTATGGATCTGTATCTACCAACCTCCAGAGAGGCAAC AGACGAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGGCAG GACAGAGATGTGTACCTTCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGACAT TTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGATTCTC ATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCGGCAAAGTTTGCT TCCTTCATCACACAGTACTCCACGGGACAGGTCAGCGTGGAGATCGAGTGGGAGCTGCAG AAGGAAAACAGCAAACGCTGGAATCCCGAAATTCAGTACACTTCCAACTACAACAAGTCT GTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTGGC ACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTT TCAGTTGAACTTTGGTCTCTGCGTGCTTCTTTCTTATCTAGTTTCCATGGCTACGTAGAT AAGTAGCATGGCGGGTTAATCATTAACTATAAGGAACCCCTAGTGATGGAGTTGGCCACT CCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGCCCG GGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 89 >#1602_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCTGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACAGAATGGCGCCGTGTGAGTAAAGCCC CCGAGGCCCAGATCACAAAGTCAGGAGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAACCGACTTTGCCATACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCTTTCA ATGCGGCCTCCAACTCGCGGTCCCATATCAAGGCTGCTTTGGACAATTCTGGAAAGATCA TGAGCCTTACTAAAATGGCATTTGACCCAGCCTATATCCAGCAGCCCGTGGAGGACATTT CCAGCAACCGGATCTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCTCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAATGATTGCGTCGACAAAATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGTCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAASGGACTCGACAAAGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAMCCTCTGGGCCYGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACTCAGACTCAAGCTCCAGGGATATG AGAAAAGTATTTTCTGCAGCAGCCCCCACAAGTTTGGGATCTACTACAATGGCTTCAGGC GGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGGGGATTC CGGCCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTTAGCTACACTTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAGACACAAACAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGA CCAACCAACATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCAGCTACA AAGTATCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCAAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACAACCAATCCCGTGGCTACGGAGCAGTATGGTTCTGTATCTACCAACCTCCAGAGAGGC AACAGACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGATGTGTACCTTCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTACCTGCGAATCCTTCGACCACCTTCAGTGCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAAMAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGGTTAATCATTAACCACAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 90 >#1010_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGYGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGAGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACAGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTAGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TTACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCTGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATTTTGGAACTAAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTTGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCTATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA AYCAGAATTCAAATATTTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTTTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGGGGAGACCCTCTCTCAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGRCGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAACCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAACACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA CACATCCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGCCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTACTACGATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAACTTTTTTCAAATTAAAATAAATGCC TCGAACGACAATCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTCTCATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGMCTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCSCAYCAAGGRTGCCYCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GKAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACATCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCAAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATAGACAAGCAGCTACCGCAGATGTCAACACACAAGGCGTTCTTCCAGGCATGGTCTGG CAGGACAGAGATGTGTACCTTCAGGGGCCCATCTGGGCAAAGATTCCACACACGGACGGA CATTTTCACCCCTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGATT CTCATCAAGAACACCCCGGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAAAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTATAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 91 >#985_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGAGCGAGCCGACTTTGCCAAACTGGTTCGCGG TGACAAAGACCCGAAATGGCGCCGGAGGCGGGAACGAGGTGGTGGATGAGTGCTACATCC CCAATTACTTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCACGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGGAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGCC TGGATCATGACTTTGGGAAGGTCACAAAGCAGGAAGTCAAAGACTTTTTTCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCAGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGTAGACAATGCGAAAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCATATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCCCTCTGCAGGAATAAGTCAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGACGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCT TCAAATGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAAACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGGCTCG GGGTACGGGCTCCGGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCAAGGCTTCAGTTTTCTCAGGCCGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACATCTGCGGATAACAACAACAGTGAATACTCGTGGACTGGAGCTACC AAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCGGCCATGGCAAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACAACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGACTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTTATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 92 >#667_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGAG AGAGCTGCCCGCCTCGGCTCTCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGAAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCTC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACTGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACGCAGACCCTCCATGCCGCCGCAGGCGGGAACACAGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATCACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCBTGGACAATGCGGGAAAGATCA TGAGCCTRACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATTTTGGAACTCAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCCGCCAAAGCCATTC TCGGAGGAAGCAAGATGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGKCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATTTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAAGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCTGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAATGGAAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATTTGCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCGGTGGGGGGATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGAMGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTTCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTACTTGAGC AGAACAAACACTCCAAGTGGAACCACCACGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAGGACGATGAAGAAAAGTTTTTTCCTCAGAGCGGGGTTCTCATCTTTGGGAAGCAAGGC TCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACAACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCCCTCATGGGTGGATTCGGACTTAAACACCCTCCTCCACAGATC ATGATCAAAAGCTCTSCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCAAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 93 >#2806_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGTTGTCCAGAGCAGCCTTGATTTGGGACCGCGGAAGTTGGAGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGARTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCAGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCTGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGATGCGC CGGTGATCAGATCAAAAACTTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCAGACTACCTAGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATTTTGGAACTAAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTAGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACAAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCYAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCRATCAACTACGCAGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGACCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACAACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAACACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAACAGCCT GCGAAAAAAAGACTGAAGTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAACAAATTTCCAGCCAATCAGGAGCC TCGAACGACAATCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTACCTTCAGCTACACTTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGACCGTCTCATGAATCCTCTCATTGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGAAACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTT TCCACAGCAGCTACGCTCACAGCCAGAGTCTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTTTATCAAAGCAGGCAAACGACAACAATAACAGCAACTTTCCCTGGACTGCAGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGTCAT AAAGACGATGAAGAAAAGTTTTTCCCTCAGAGCGGGGTTCTCATCTTTGGRAAACAAGGC TCAGARAAAACCAATGTGGACATTGAAAAGGTCATGATTACAGACGAAGAGGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATATGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGACTTAAACACCCTCCTCCACAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCYACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGAGTGGAGATCGAGTGGGAGCTG CAGAAGGAAAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTACAACAAR TSTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCYTCGCCCCATT SGCACCAGATMCCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTATTTTTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGAGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 94 >#217_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCTGAGACGGAGTTTTGCTTTTGTTGCCCAGGCTGGA GTGCTATGGCGCGTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTTTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGATGCGC CGGTGATCAGATCAAAAACTTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCTTGGACAATGCGGGAAAGATTA TGAGCCTCACTAAAACCGCCCCCGACTACCTGGTGGGCCAGTCTCTCTCTCTGCACAGCC TTTAGTACAAGTTAAAGTAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCT TCCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACTATCTGGCTGTTT GGGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTC TACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAACGACTGTGTCGACAAGATG GTGATCTGGTGGGAGGAGGGGAAAATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCCATT CTCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCG ACTCCTGTGATTGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACG ACCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGT CTGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCA AAGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAA AGACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCG CAGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAA TGTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATG AATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCC GTGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATT CATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGAT TTGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTA TCTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAA ACCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGT GCTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAA CGAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGG AGACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGA AGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCT TGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGT AGAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCC TGCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCA GCCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGG CAGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGG AAATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAAC CTGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGC CTCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAG ATTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATT CCGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAA TGACGGTACGAAGACCCCCGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTC GGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCACCAAGGATGCCTCCCGCCGTTCCC AGCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGC GGTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGG AAACAACTTTACCTTCAGCTACACTTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCA CAGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAA CAAAACACAATCAAATAGTGGAACTAACACGCAGTCAAGGCTTCAGTTTTCTCAGGCCGG AGCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTGCCTGGACCTTGCTACAGACAGCA GCGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACAGGAGCTAC CAAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCAGCTATGGCCAGCCA CAAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGG AACAAATGCTAACGACGCAGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCG CACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTC AAATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTG GCAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGG ACACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGAT CATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTT TGCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCT GCAGAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAGTACACTTCCAACTACAACAA ATCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCAT TGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATT CGTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACG TAGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGG CCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGAC GCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCA A SEQ ID NO: 95 >#767_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCTC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACTGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAGCAAAGAAAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATCACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATTTTGGAACTCAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAAGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATTTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAAGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAACTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAATTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCAAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCTGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATTTCCAGCCAATCAGGAGCC TCGAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGATTCCAC TGCCACTTTTCACCACGTGATTGGCAAAGACTCATCAACAACAACTGGGGATTCCGACCC AAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAATGACGGT ACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGGAGTAC CAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCAGCGGAC GTCTTCATGGTTCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCGGTAGGA CGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGAAACAAC TTTACCTTCAGCTACACTTTTGAGGACGTTCCTTTCCACAGCAGCTACGCTCACAGCCAG AGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAACAAAACA CAATCTAGTGGAACTCTTCAGCAGTCTCGGTTACTGTTTAGTCAAGCTGGACCCACCAGC ATGTCTCTTCAAGCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAGCGAGTATCA AAGACATCTGCGGATAAAAACAACAGTGAATACTCGTGGACTGCGGCTACAAAGTATCAT CTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCACAAAGACGAT GAAGAAAAGTTTTTCCCCATGCCTGGAACCCTGATATTTGGTAAAGAAGGAACAAATGCT AACAACGCAGAATTGGAAAATGTCATGATTACAGATGAAGAAGAAATCCGCACCACCAAT CCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCAAATACTGGT CCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGGCAGGATCGA GACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGACACTTTCAT CCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCACCTCCTCAGATCATGATCAAA AACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTGCGGCAAAATTTGCTTCCTTT ATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAAATCGAGTGGGAGCTGCAGAAGGAG AACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTACAACAAGTCTGTTAAT GTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTGGCACCAGA TACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTT GAACTTTGGTCTCTGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGTAGATAAGTA GCATGGAGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTC TCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGCCCGGGCTT TGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 96 >#1591_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTATACGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCTAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCA CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TTACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTTGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATTCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCGCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAGATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTATTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGRAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTTGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTTGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGCCAGACGCTTGCACAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTGAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAAAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGTTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGARGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA GCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCTGGACCCTGTTACCGCCAGCAG CGAGTATCAAAGACATCTGCGGATAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTTATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGACAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTTTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTACGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 97 >#508_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA] [isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGGGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACAGAATGGCGCCGTGTGAGTAAAGCCC CCGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TCGTGGAAACCACGGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTATCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAATAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCTGTGGAGGACATTT CCGGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACKAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCKTTCAATGATTGCGTCGACAAAATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAATCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAACATGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAACGCTATTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCAGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGACATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCTTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCATCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACMTMTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCAGTA GCGCACTCTCCTGCGGAACCAGACTCCTCCTCGGGAACCGGAAARGCGGGCAACCAGCCT GCAAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCYGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCACAAGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCGGGA AATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCACCTCTACAAGCAGATCTCCAGCCAATCAGGAGCT TCRAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAAATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACTTTTGAAGACGTGCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTTTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTAAAC AGGACACAAACAGCCAGTGGAACTCAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGACCC ACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAGCGT CTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTACTCGTGGACTGGAGCTACCAAG TACCACCTCAATGGTAGAGACTCTTTGGTGWACCCGGGCCCTGCTATGGCCAGCCACRAA GACGATGAAGRAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAAGAAGGAACA AATGCTACCAACGCGGATTTGGACAATGTCATGATTACAGACGAAGAGGAAATCAGGACA ACAAATCCTGTAGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCAAAC ACTGCTGCAACTACTGAAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGGCAG GACCGAGACGTGTACCTACAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGACAC TTTCATCCTTCTCCCCTCATGGGCGGATTCGGACTCAAAAACCCACCTCCTCAGATCATG ATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTTGCT TCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTGCAG AAGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTACAACAAGTCT GTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATTGGC ACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTT TCAGTTGAACTTTGGTCTCCGCGTCACGACTCCACCCCTAGTTTCCATGACTACGTAGAT AAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCCACT CCCTCTCTGCGCGCTCGCTCGCTCCCTGAGGCCGGGCGACCAAAGGTCGCCCGACGCCCG GGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 98 >#1704_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAGG GTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCATG TGGTCACGGTGGGTATTTAAGCCCAAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGAG GTTTGAATACGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCAAGCGA CCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGGA ATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGAC CGTGGCCGAAAAGCTGCAGCGCGACTTTCTGACAGAATGGCGCCGTGTGAGTAAGGCCCC CGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTATTTCCACATGCACGTGCT CGTGGAGACCACGGGGGTAAAATCCATGGTTTTAGGACGTTTCCTGAGTCAGATTCGCGA AAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAATTGGTTTGCGGT CACAAAGACTCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCCC CAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAACA GTATTTAAGCGCCTGTTTGAACCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGAC GCACGTGTCGCAGACCCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGCC GGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATAA GGGGATTACCTCTGAGAAGCAGTGGATTCAGGAGGACCAGGCCTCATACATCTCCTTCAA TGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAAATCAT GAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATCTC CGGCAATCGGATTTATAAAATCTTGGAACCGAACGGGTACGATCCCCAATACGCGGCTTC CGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTGG GCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCTA CGGGTGCGTAAACTGGACCAATGAAAACTTTCCTTTCAACGATTGCGTCGACAAGATGGT GATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTCT CGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATCGACCCGAC TCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGAC CTTCGAGCACCAGCAGCCGTTGCAAGGGATGTTCAAATTTGAACTTACCCGCCGTCTGGA TCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAAAGGA TCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAAGACC CGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGCAGCC ATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAATGTTC TCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGAATCA GAATTCAAATATCTGCTTTACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCGTGTC AGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTCATCA TATCATGGGAAAGGTGCCAGACGCTTGCACTGCTTGCGACCTGGTCAATGTGGATTTGGA TGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTATCTTC CAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAACCTG GCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTGCTTC CTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAAGGAGAGCCGGTCAACGAGG CAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGAGACA ACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTCCAGGAGCGCCTTAAAGAAGATA CGTCTTTTGGGGGCAACCTCGCAAGAGCAGTTTTCCAGGCAAAAAAGAGGGTTCTTGAAC CTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTAGAGC ACTCTCCTGCGGAGCCAGATTCCTCCTCCGGAACTGGAAAGTCGGGCAACCAGCCTGCAA GAAAGAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAGCCTC TCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGCAGTG GCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCGGGAAATT GGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACCTGGG CCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCCTCGA ACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGATTCC ACTGCCACTTCTCGCCACGCGATTGGCAAAGACTCATCAACAACAACTGGGGATTCCGGC CCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAATGACG GTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGGAGT ACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCAGCAG ACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCGGTAG GACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTACGTACCGGAAACA ATTTCACCTTCAGCTACACTTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCACAGCC AGAGTCTGGATCGGCTGATGAATCCTCTCATCGACCAGTACCTGTATTATCTGAACAAGA CACAAACAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGACCCA CCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAGCGTC TGTCAAAGCAGGCAAACGACAACAACAACAGCAATTTTCCCTGGACTGCGGCTACAAAGT ATCATCTAAATGGCCGGGACTCTCTGGTGAATCCAGGACCAGCTATGGCCAGTCACAAGG ATGACGAAGAAAAGTTTTTCCCCATGCATGGAACATTGATATTTGGTAAACAAGGAACAA ATGCCAACGACGCGGATTTGGAAAATGTTATGATTACAGATGAAGAAGAAATCAGGACCA CCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCAAACA CTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGGCAGG ATAGAGACGTATACCTACAGGGTCCCATTTGGGCCAAGATTCCTCACACCGATGGACACT TTCATCCTTCTCCGCTGATGGGAGGTTTTGGACTCAAACACCCGCCTCCTCAGATCATGA TCAAAAACACTCCCGTTCCAGCCAATCCTCCCACGAACTTCAGTTCTGCCAAGTTTGCTT CTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTGCAGA AGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTACAACAAGTCTG TTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTGGCA CCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTT CAGTTGAACTTTGGTCTCTGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGTAGAT AAGTAGCATGGAGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCCACT CCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGCCCG GGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 99 >#2112_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTACGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTACGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTTGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATTAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTG GACCTGCGACCACGGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAATGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATYGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACAAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCTAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCAGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCCAAGAAAACCTATTTTTCGATATACGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATCAGGACAACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAASCAGCCT GCGRGAAAAAGATTGAATTTTGGTCAGACTGGAGWCGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGAACTAATACGATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATAGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAAAGCAGGCAAACGACAACAACAACAGCAA CTTTCCCTGGACTGCGGCTACAAAGTATCAACTAAATGGCCGGGACCAGCTATGGCCAGC CACAAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAA GGAACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATC CGCACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAAC TCAAATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTG TGGCAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGAT GGACACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAG ATCATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAG TTTGCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAG CTGCAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATCCAGTACACTTCCAACTACAAC AAGTCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCC ATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAA TTCGTTTCAGTTGAACTTTGGTCTCTGTGTACTTCTTTCTTATCTAGTTTCCATGGCTAC GTAGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTG GCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGA CGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCC AA SEQ ID NO: 100 >#1350_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGTTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCTC CGGAAGCCCTTTTTTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTCTTAGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAATTGGTTCGCGG TTACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTATATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAAAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTTA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGGAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCTTTTT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAACGACTGTGTTGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAGGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGACCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAGACACAGTCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAACAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGGCCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAGAGCGGC AACACACAAGCAGCTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGTGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 101 >#668_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACTCCCGTGATCGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGG CCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAGG GTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCATG TGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGAG GTTTGAACACGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCGA CCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGGA ATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGAC CGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCCC GGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTTCT GGTGGAGACTACCGGGGTAAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCGA AAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGGT TACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCCC CAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAACA GTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGAC GCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAAAATCCCAATTCTGACGCGCC GGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATAA GGGGATTACGTCGGAGAAGCAGTGGATTCAGGAGGACCAGGCCTCATACATCTCCTTCAA TGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCAGGAAAGATCAT GAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTAGAGGACATTTC CAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTTC CGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTGG GCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCTA CGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAACGACTGTGTCGACAAGATGGT GATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTCT CGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGAC TCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGAAACTCAACGAC CTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTCT GGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAAA GGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAAG ACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGCA GCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAATG TTCTCGTCACGTGGGCAAGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGAA TCAAAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCGT GTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTCA TCACATAATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCAATCTGGTCAATGTGGATTT GGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTATC TTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAAC CTGGCCCACCGCCACCAAAGCCCGCAGAGCGGCATAAGGACGACAACAGGGGTCTTGTGC TTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAACG AGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGAG ACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAAG ATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTTG AACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTAG AGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCTG CAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAGC CTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGCA GTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGAA ATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACCT GGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCCT CAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGAT TCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTCC GACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAATG ACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGG AGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCACCAAGGATGCCTCCCGCCGTTCCCAG CGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCGG TAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGAA ACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCACA GCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAACA AGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGAC CCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAGC GTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACAA AGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCGGGCCCGGCTATGGCCAGCCACA AAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGAA CAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGCA CCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCAA ATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGGC AGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGAC ACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATCA TGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTTG CTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTGC AGAAAGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTATAACAAGT CTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATTG GCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCG TTTCAGTTGAACTTTGGTCTCTGTGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 102 >#367_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCATGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACACAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATTA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAACAATCGAATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCTGCTT CCGTCTTTCTGGGATGGGCCACGAAGAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGAAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAAAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGATTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCACCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCAGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCAAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGCTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 103 >#1020_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTAAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GTTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCGGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATTTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTACAATTTGAGAAGGGAGAGAGCTATTTCCACATGCACGTGC TCGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGTG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCAGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTAAATCTCTCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAAGGAAAGATGACTGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TTGGCGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGATCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATTTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTACCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGATTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCACCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTACCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCAGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGTCAC AAGGATGACGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCCAACGACGCGGATTTGGAAAATGTCATGATTACAGACGAAGAAGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTATGGGACTGTGTCAAATAATTTGCAAAACTCA AACACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTATGCGTACTTCTTTTCTTATCTGGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGGCTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 104 >#1158_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGTCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAAAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTATTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATTGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTTA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTCACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATAGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAAGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGTGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TAGATCATGACTTTGGGAAGGTTACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGAGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCATGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGAAAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTAGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTTCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAGTATACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTTTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGAGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 105 >#2107_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGTGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGTTACTTCCACATGCACATGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACATCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTTGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACCACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACTGCCAAGGTCGTGGAGTCTGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACATCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATTATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCAGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCAGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAAGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTCCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 106 >#1570_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] GGACTCGCGGCCGCAAGTGGATAGGTGGAGCGATTTGAGGTCTATGGTGTAAAAGGAAAT ATCTTCACCACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGTGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGTTACTTCCACATGCACATGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACATCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCKTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTTGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACCACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACTGCCAAGGTCGTGGAGTCTGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACATCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAAAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATTATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAAACACAAGCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCAGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAA GGAACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATC CGCACCACCAATCCCGTGGCTACGGAGCAGTACGRATATGTGTCAAATAATTTGCAAAAC TCAAATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTG TGGCAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGAT GGACACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAG ATCATGATCAAAAACACTCCAGTTCCTTCTCCGCTGATGGGAGGTTTTGGGCTCAAACAC CCGCCTCCTCAGATCACACAGTATTCCACGGGGCAAGTCAGCGTGGAGATCGAGTGGGAG CTGCAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAAC AAATCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCC ATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAA TTCGTTCCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTA CGTAGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTT GGCCACTCCCTCTCTGCGCGCTCGCTCGAGGAAAAAACTTTTCTTCATTTTGTGCACTGA GGCCGTTTTTGCTTTCTTAAGTAATAGGCTTGGAATTTATCCCGGAATACATCTCTTAAA GTT SEQ ID NO: 107 >#704_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGGG CGTCGGGCGACCTTGGCTTGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGAGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTAAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAAGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTATTTCCACATGCACGTGC TTGTGGAGACCACCGGAGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACCCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGATCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTATTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATTTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCGTTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGAGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCAACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATTATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTTCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAGATC ATGATCAAAAACACTCCAGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATGTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 108 >#714_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGTCCAAAGGTCGCC CGACGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATGTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGATCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAAGACATTT CCAGCAATCGGATTTATAAAATTTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTTGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAAAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAAGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCAAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAATCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAAGCG GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACCGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGATGACGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCAGG ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCACCCTTCTCCACTGATGGGAGGTTTTGGACTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAATTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAAATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAGTATACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGTGTACTTCTTTTCTTATATAGTTTCCATGGCTACGT AGATAAGTAGCATGGCGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCGCGGGCAAAGCCCGGCCGTCGG GCGACCTTTGCCCGGGCGACCTTAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 109 >#3086_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGG CGTCGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCTGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCTCAATTCTGACGCGC CGGTTATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATTCAGGAAGACCAGGCTTCATACATATCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCTTGGACAATGCGGGAAAGATTA TGAGCCTCACTAAAACTGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTTCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTAGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTTACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACAAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATATGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACAACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAGCCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAACAGCCT GCGAAAAAAAGACTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGA CCCACCAACATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTTTATCAAAGCAGGCAAACGACAACAATAACAGCAACTTTCCCTGGACTGCAGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGTCAT AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCCAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACAAATCCTGTAGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATATGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGACAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCTAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTTTGCGTACTTATTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTGCCATGGTGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCGG GCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGATTCAAACAGAGAGGGAGTGGCCAA SEQ ID NO: 110 >#3142_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGG CGTCGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGATCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTAAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAAAAGCTGCAGCGCGAGTTTCTGACGGAATGGCGCCGTGTGAGTAAAGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCCGAGAAGCAGTGGATTCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGTCAGCAGCCCGTGGAGGACATTT CCGGCAATCGGATTTATAAGATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGAAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTTT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCGTTCAATGACTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCTTCGGCCCAGATCGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC ATCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTTACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGAAGACTTATCAGAAACTGTGTCCAA TTCATCACATTTTGGGAAGAGCACCCGAGATTGCGTGTTCGGCCTGCGATCTGGCCAATG TGGACTTGGATGACTGTGTTTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGAT GGTTATCTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAG CTCAAACCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGT CTTGTGCTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCG GTCAACGAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGAC AGCGGAGACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTT AAAGAAGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGG GTTCTTGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGG CCGGTAGAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCAAC CAGCCTGCAAGAAAAAGACTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGAC CCCCAGCCTATCGGACAGCCACCAGCAGCCCCCACAAGTTTGGGATCTACTACAATGGCT ACAGGCAGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCC TCAGGAAATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATTACCACCAGCACC CGAACCTGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAGATCTCCAGCCAATCA GGAGCTTCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTC AACAGATTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAATTGG GGATTCCGGCCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACG CAGAATGACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACT GACTCGGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCG TTTCCAGCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTAAACAACGGGAGT CAGGCGGTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGT ACTGGAAACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTAT GCTCACAGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTAT CTGAACAAGACACAATCAAATAGTGGAACTGTTCAGCAGTCTCGGCTACTGTTTAGCCAA GCTGGACCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGA CAGCAGCGTCTGTCAAAGCAGGCAAGCGACAACAACAACAGCAACTTTCCCTGGACTGCG GCTACAAAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCC AGTCACAAGGATGACGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAA GAAGGAACAACTTCTAACAACGCGGATTTGGAACATGTCATGATTACAGATGAAGAAGAA ATCAGGACCACTAATCCAGTGGCTACGGAGCAGTACGGAAATGTGTCAAATAATTTGCAA AACTCAAATACTGGTCCAACTACTGAAAATGTCAATAACCAAGGAGCGTTACCTGGTATG GTGTGGCAGGATAGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCACACACG GACGGACACTTTCATCCTTCTCCGCTTATGGGAGGTTTTGGACTCAAACACCCACCTCCT CAAATCATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTGCGGCA AAGTTTGCTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGG GAGCTGCAGAAAGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAATTAC AACAAATCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGC CCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTT TAATTCGTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTTATTATCTAGTTTCCATGG CTACGTAGATAAGTAGCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGA GTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGG GCGTCGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGT GGCCAA SEQ ID NO: 111 >#1024_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGTATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAAG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTAGCCGAGAAACTGCAGCGCGACTTTCTGACAGAATGGCGCCGTGTGAGTAAGGCCC CCGAGGCCCTCTTTTTTGTGCAATTTGAAAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAGTCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAATTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGACGAGTGCTACATCC CCAATTACCTGCTCCCTAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAACCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACCCAGGAGCAGAACAAAGAAAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCCGAGAAACAGTGGATTCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCTCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATTA TGAGCCTCACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCGGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACGGTGCCCTTCT ACGGGTGCGTAAACTGGACCAACGAGAACTTTCCCTTTAACGACTGCGTCGACAAGATGG TGATTTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAATCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGACATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCGTGCAAAACCTGCGAGAGAATGA ATCAGATTTCAAATGTCTGTTTCACGCACGGTGTCAAAGACTGTGGGGAGTGCTTTCCCG TGTCAAAATCTCAACCCGTTTCTGTCGTCAAAAAGAAGACTTATCAGAAACTGTGTCCAA TTCATCACATTTTGGGAAGAGCACCCGAGATTGCGTGTTCGGCCTGCGATATGGCCAATG TGGACTTGGATGACTGTGTTTCTGAACAATAAATGACTTAAACCAGGTATGGCTGCCGAT GGTTATCTTCCAGATTGGCTCGAGGACAACCTCAGTGAAGGAATTCGCGAGTGGTGGGCT TTGAAACCTGGAGCCCCTCAACCCAAGGCAAATCAACAACATCAAGACAACGCTCGGGGT CTTGTGCTTCCGGGTTACAAATACCTTGGACCCGGCAACGGACTCGACAAGGGGGAGCCG GTCAACGCAGCAGACGCGGCGGCCCTCGAGCACGACAAGGCATACGACAAGCAGCTCAAG GCCGGAGACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTT AAAGAAGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGG GTTCTCGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGG CCGGTAGAGCACTCTCCTGCGGAGCCAGATTCCTCCTCCGGAACTGGAAAGTCGGGCCAA CAGCCTGCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGAC CCCCAGCCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCT ACAGGCAGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCC TCAGGAAATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACC CGAACCTGGGCCCTGCCCACCTACAACAATCACCTCTACAAGCAAATCTCCAGCCAATCA GGAGCTTCGAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTC AACAGATTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGG GGATTCCGACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACG CAGAATGACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACT GACTCGGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCG TTTCCAGCGGACGTCTTCATGGTGCCACAGTATGGATACCTCACCCTAAACAACGGGAGT CAGGCGGTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGT ACAGGAAACAACTTTCAGTTCAGCTACACTTTTGAAGACGTGCCTTTCCACAGCAGCTAC GCTCACAGCCAGAGTCTGGATCGGCTAATGAATCCTCTGATCGACCAGTACCTGTATTAT CTAAACAGGACACAAACAGCCAGTGGAACTCAGCAGTCTCGGCTACTGTTTAGCCAAGCT GGACCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAA CAGCGTTTGTCAAAGCAGGCAAACGACAACAACAATAGCAACTTTCCCTGGACTGCGGCT ACAAAGTACCACCTCAATGGCAGAGACTCTCTGGTGAATCCGGGCCCTGCTATGGCCAGT CACAAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAAGAA GGAACAAATGCTACCAACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATC CGCACCACAAATCCTGTAGCTACGGAGCAGTATGGATATGTGTCAAATAATTTGCAAAAC TCAAATACTGCTGCAACTACTGAAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTG TGGCAGGATAGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAAATTCCTCACACCGAT GGACACTTTCATCCTTCTCCGCTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAG ATCATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTTAGTGCGGCAAAG TTTGCTTCTTTCATCACACAGTATTCCACGGGGCAAGTCAGCGTGGAGATCGAGTGGGAG CTGCAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAAC AAATCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCC ATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATTAATAAACCGTTTAA TTCGTTTCAGTTAAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTAC GTAGATAAGTACCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTG GCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGT CGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCC AA SEQ ID NO: 112 >#790_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGG CGTCGGGCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGAG GTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCGA CCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGGA ATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGAC CGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCCC GGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGCT TGTGGAAACTACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCGA AAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGGT CACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCCC CAATTACCTGCTCCCCAAAACCCAACCTGAGCTCCAGTGGGCGTGGACTAATATGGAACA GTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGAC GCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGCC GGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTTGTCGGGTGGCTCGTGGATAA GGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCAA TGCGGCCTCCAACTCGCGGTCTCAAATCAAGGCTGCTCTGGACAATGCGGGGAAGATTAT GAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTTC CAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATATGCGGCTTC CGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTGG GCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCTA CGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAATGATTGCGTCGACAAGATGGT GATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTCT CGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGAC TCCCGTGATCGTCACTTCAAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGAC CTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTCT GGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTGAAAGACTTTTTCCGGTGGGCAAA GGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAAG ACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCACA GCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAATG TTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGAA TCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCGT GTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTCA TCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATTT GGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTATC TTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAAC CTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTGC TTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAACG AGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGAG ACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAAG ATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTTG AACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTAG AGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCAACCAGCCTG CAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAGC CTCTCGGACAACCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGCA GTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGAA ATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACCT GGGCTCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCTT CAAACGACAACCACTATTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGAT TCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTCC GACCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAATG ACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCGG AGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCAG CGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCGG TAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGAA ACAACTTTCAGTTTAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCACA GCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTAAACA AGACACAATCAAATAGTGGAACTCTTCAACAGTCTCGGCTACTGTTTAGTCAAGCTGGAC CCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAGC GTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACAA AGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCACA AAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGAA CAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGCA CCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCAA ATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGGC AGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGAC ACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATCA TGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTTG CTTCTTTCATCACACAGTACTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTGC AGAAGGAGAACAGCAAACGCTGGAACCCCGAGATTCAGTACACTTCCAACTACAACAAAT CTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATTG GCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTCG TTTCAGTTGAACTTTGGTCTCTGCGTACTTTTTTCTTATCTAGTTTCCATGGCTACGTAG ATAAGTAGCATGGCGGGGTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCCA CTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGGGCGTCGCC CGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 113 >#976_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATTTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAATGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAAACCACCGGGGTGAAATCTATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCATGTATCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTTGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCCTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCGCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACGGCCCCCGACTACCTGGTGGGCCAGCAACCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTATGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCTACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCTATAGCCCACACTGTGCCCTTTT ACGGGTGCGTGAACTGGACCAATGAGAACTTTCCTTTCAACGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTCCCACAGTATGGATATCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTTAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCAGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGTGTGCTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTACCATGGCGGGTTAATCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACGC CCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 114 >#1286_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTATAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCTCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAATAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCCTTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGATACGATCCCCATTACGCGGCTT CCGTCTTTCTGGGATGGGCCACTAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCGTTCAATGATTGCGTCGACAAGATGG TGATTTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGCGGAAGCAAGGTGCGCGTGGACCAAAAGTGCAAGTCTTCGGCCCAGATCGACCCGA CTCCCGTGATAGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTGTGCTACATTC ATCACATCATGGGAAAGGTGCCAGACGCTTGCACTGCTTGCGACCTGGTCAATGTGGACT TGGATGACTGTGTTTCTGAACAATAAATGACTTAAACCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCTCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC AGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACAACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCA GTAGGACGCTCTTCATTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAAACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTTATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AACACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACGGACGGA CATTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCTACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTA CAGAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAGTATACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGAGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGACG CCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 115 >#163_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAATTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA GGTTTGAACGCGCAGCCGCCATGCCGGGATTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCCCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TTGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGAATCGAGCCGACTTTGCCAAACTGGTTCGCGG TCACAAAGACCAGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACTCAGGAGCAGAACAAGGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACGTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCTCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGACCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCCATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCTTTCAATGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCATGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGAAGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAAAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAGTGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCT TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAGAAACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCTAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTCTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTAAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGACTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGCAATCTGTAATTGCTTGTTAATCAATAAACCGTTTGATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAACCTCTCTGCGCGC TCGCTCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 116 >#685_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTTACGCAGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTAAAGCGGGA GGTTTGAACACGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATTTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGGATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGTGTGAGTAAGGCCC CGGAGGCTCTTTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAACTGGTTTGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAGATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTAACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAACTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCTACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATTGCGGAGGCTATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCATTCAATGATTGCGTCGACAAGATGG TGATCTGGTGGGAGGAGGGAAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGCAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGAAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCAAGTGACGCAGATATAAGTGAGCCCAAACGGGTGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTATTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATTTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCATATCAGAAACTGTGCTACATTC ATCATATCATGGGAAAGGTGCCAGACGCTTGCACTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGTATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTCAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAAACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGCGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTTTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCAACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATTTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCTTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTCTTTATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTAAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTAAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACAAATGCCAACGACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGGCTCAAACACCCGCCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCAACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGACAGGTCAGCGTGGAGATTGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAATCCCGAGATTCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTCTTATCTAGTTTCCATGGCTACGT AGATAAGTAGCATGGTGGGTTTATCATTAACTATAAGGAACCCCTAGTGATGGAGTTGGC CACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCG GGCGACCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 117 >#442_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGGTCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCTGGGTATTTAAGCCCGAGTGAGCACGCAGGGTCTCCATTTTAAAGCGGGA GGTTTGAACGGGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGCACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGAATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACGGAGTGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAGAGCTACTTCCACATGCACGTGC TGGTGGAGACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAGTTTACCGCGGGATCGAGCCGACTTTGCCAAATTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAATCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACGCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCAC CGGTGATCAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGACA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAACTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCAGACTACCTAGTGGGCCAGCAGCCCGTGGAGGACATTT CCAGCAATCGGATTTATAAAATCTTGGAATTGAACGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAGGCTATAGCCCACACTGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGTAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAACACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTCACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTCAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCCAAGAAAA GACCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAAGTGCCAGACGCTTGCAGTGCCTGCGATCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTTAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGCCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCTCCGGGAAAAAAGAGGCCGGTA GAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAAGCGGGCCAGCAGCCT GCAAGAAAGAGATTGAATTTCGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAACCACCAGCAGCCCCCTCTGGTCTGGGATCTACTACAATGGCTACAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCC TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGGCCCAAGAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAAGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTCCCA GCAGACGTTTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCTTGGAGTACTTTCCTTCTCAGATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATCGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACACTTCAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAATTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAAACGACAACAACAACAGCAACTTTCCCTGGACTGCGGCTACA AAGTATCATCTCAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGATGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACTGGAAGAGACAACGCGGATTTGGACAATGTCATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AACACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAGATC ATGATTAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTCAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAGGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAA TCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTC GTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTA GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCC ACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGCCCGGGCGTCGG GCGACCTTTGGTCGCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA SEQ ID NO: 118 >#2320_AAV.FL.linear [organism = Adeno-associated virus][mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCC CGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTG GCCAACTCCATCACTAGGGGTTCCTGGAGGGGTGGAGTCGTGACGTGAAGTACGTCATAG GGTTAGGGAGGTCCTGTATTAGAGATCACGTGAGTGTTTTGCGACATTTTGCGACACCAT GTGGTCACGCCGGTTAGTTAAGCTCGAGTGAGCACGCAGGGTCTCCATTTTGAAGCGGGA AGTTTGAACGCGCAGCCGCCATGCCGGGGTTTTACGAGATTGTGATTAAGGTCCCCAGCG ACCTTGACGAGCATCTGCCCGGCATTTCTGACAGCTTTGTGAACTGGGTGGCCGAGAAGG AATGGGAGTTGCCGCCAGATTCTGACATGAATCTGAATCTGATTGAGCAGGCACCCCTGA CCGTGGCCGAGAAGCTGCAGCGCGACTTTCTGACAGAATGGCGCCGCGTGAGTAAGGCCC CGGAGGCCCTCTTCTTTGTGCAATTTGAGAAGGGAGAAAGCTATTTCCACATGCACGTGC TGGTGGAAACCACCGGGGTGAAATCCATGGTTTTGGGACGTTTCCTGAGTCAGATTCGCG AAAAACTGATTCAGAGAATTTACCGCGGGATCGAGCCGACTTTGCCAAATTGGTTCGCGG TCACAAAGACCCGAAATGGCGCCGGAGGCGGGAACAAGGTGGTGGATGAGTGCTACATCC CCAATTACCTGCTCCCCAAAACCCAGCCTGAGCTCCAGTGGGCGTGGACTAATATGGAAC AGTATTTAAGCGCCTGTTTGAACCTCGCGGAGCGTAAACGGTTGGTGGCGCAGCATCTGA CGCACGTGTCGCAGACCCAGGAGCAGAACAAAGAGAATCAGAATCCCAATTCTGACGCGC CGGTGATTAGATCAAAAACCTCAGCCAGGTACATGGAGCTGGTCGGGTGGCTCGTGGATA AGGGGATTACCTCGGAGAAGCAGTGGATCCAGGAGGACCAGGCTTCATACATCTCCTTCA ATGCGGCCTCCAATTCGCGGTCCCAAATCAAGGCTGCTCTGGACAATGCGGGAAAGATCA TGAGCCTGACTAAAACCGCCCCCGACTACCTGGTGGGCCAGCAGCCCGTGGAGGACATTT CCGGCAATCGAATTTATAAAATCTTGGAACTGAATGGGTACGATCCCCAATACGCGGCTT CCGTCTTTCTGGGATGGGCCACGAAAAAGTTCGGCAAGAGGAACACCATCTGGCTGTTTG GGCCTGCAACTACCGGGAAGACCAACATCGCGGAAGCCATAGCCCACACGGTGCCCTTCT ACGGGTGCGTAAACTGGACCAATGAGAACTTTCCCTTCAACGACTGTGTCGACAAGATGG TGATCTGGTGGGAGGAGGGGAAGATGACCGCCAAGGTCGTGGAGTCGGCCAAAGCCATTC TCGGAGGAAGCAAGGTGCGCGTGGACCAGAAATGTAAGTCCTCGGCCCAGATAGACCCGA CTCCCGTGATCGTCACCTCCAACACCAACATGTGCGCCGTGATTGACGGGAACTCAACGA CCTTCGAGCACCAGCAGCCGTTGCAAGACCGGATGTTCAAATTTGAACTTACCCGCCGTC TGGATCATGACTTTGGGAAGGTCACCAAGCAGGAAGTGAAAGACTTTTTCCGGTGGGCAA AGGATCACGTGGTTGAGGTGGAGCATGAATTCTACGTCAAAAAGGGTGGAGCTAAGAAAA GGCCCGCCCCCAGTGACGCAGATATAAGTGAGCCCAAACGGGCGCGCGAGTCAGTTGCGC AGCCATCGACGTCAGACGCGGAAGCTTCAATCAACTACGCGGACAGGTACCAAAACAAAT GTTCTCGTCACGTGGGCATGAATCTGATGCTGTTTCCCTGCAGACAATGCGAGAGAATGA ATCAGAATTCAAATATCTGCTTCACTCACGGACAGAAAGACTGTTTAGAGTGCTTTCCCG TGTCAGAATCTCAACCCGTTTCTGTCGTCAAAAAGGCGTATCAGAAACTTTGCTACATTC ATCATATCATGGGAAAGGTACCAGACGCTTGCACTGCTTGCGACCTGGTCAATGTGGATT TGGATGACTGCATCTCTGAACAATAAATGATTTAAATCAGGTATGGCTGCCGATGGTTAT CTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATAAGACAGTGGTGGAAGCTYAAA CCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAGGACGACAGCAGGGGTCTTGTG CTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTCGACAAGGGAGAGCCGGTCAAC GAGGCAGACGCCGCGGCCCTCGAGCACGACAAGGCCTACGACCGGCAGCTCGACAGCGGA GACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAGTTTCAGGAGCGTCTTAAAGAA GATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTCCAGGCGAAAAAGAGGGTTCTT GAAACTCTGGGCCTGGTTGAGGAACATGTTAAGACGGCTCCGGGTAAAAAGAGGGCGGTA GAGCATGCTCATGTGGAGCCAGACTCCTCCTCGGGAACCGGAAAGGCGGGCCAGCAGCCT GCAAGAAAAAGATTGAATTTTGGTCAGACTGGAGACGCAGACTCCGTACCTGACCCCCAG CCTCTCGGACAGCCACCAGCAGCCCCCTYTGGTYTGGGATCTACTACAATGGCTTCAGGC AGTGGCGCACCAATGGCAGACAATAACGAGGGTGCCGATGGAGTGGGTAATTCCTCAGGA AATTGGCATTGCGATTCCCAATGGCTGGGCGACAGAGTCATCACCACCAGCACCCGAACC TGGGCCCTGCCCACCTACAACAACCACCTCTACAAGCAAATCTCCAGCCAATCAGGAGCT TCAAACGACAACCACTACTTTGGCTACAGCACCCCCTGGGGGTATTTTGACTTCAACAGA TTCCACTGCCACTTTTCACCACGTGACTGGCAAAGACTCATCAACAACAACTGGGGATTC CGACCCAAAAGACTCAACTTCAAGCTCTTTAACATTCAAGTCAAGGAGGTCACGCAGAAT GACGGTACGACGACGATTGCCAATAACCTTACCAGCACGGTTCAGGTGTTTACTGACTCG GAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAAGGATGCCTCCCGCCGTTTCCA GCGGACGTCTTCATGGTCCCACAGTATGGATACCTCACCCTGAACAACGGGAGTCAGGCG GTAGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCTTCTCAAATGCTGCGTACTGGA AACAACTTTCAGTTCAGCTACACCTTTGAAGACGTTCCTTTCCACAGCAGCTACGCTCAC AGCCAGAGTCTGGATCGGCTGATGAATCCTCTGATTGACCAGTACCTGTATTATCTGAAC AAGACACAATCAAATAGTGGAACTCTTCAGCAGTCTCGGCTACTGTTTAGTCAAGCTGGA CCCACCAGCATGTCTCTTCAAGCTAAAAACTGGCTGCCTGGACCTTGCTACAGACAGCAG CGTCTGTCAAAGCAGGCAACGGATAACAACAACAGTGAATTTCCCTGGACTGCGGCTACA AAGTATCATCTCAATGGCCGGGACTCGTTGGTTAATCCAGGACCAGCTATGGCCAGCCAC AAAGACGATGAAGAAAAGTTTTTCCCCATGCATGGAACCCTGATATTTGGTAAACAAGGA ACTAAATGCAACGACGCGGATTTGGACAATGTTATGATTACAGATGAAGAAGAAATCCGC ACCACCAATCCCGTGGCTACGGAGCAGTACGGATATGTGTCAAATAATTTGCAAAACTCA AATACTGGTCCAACTACTGGAACTGTCAATCACCAAGGAGCGTTACCTGGTATGGTGTGG CAGGATCGAGACGTGTACCTGCAGGGACCCATTTGGGCCAAGATTCCTCACACCGATGGA CACTTTCATCCTTCTCCACTGATGGGAGGTTTTGGACTCAAACACCCACCTCCTCAGATC ATGATCAAAAACACTCCCGTTCCAGCCAATCCTCCCACAAACTTTAGTTCTGCCAAGTTT GCTTCTTTCATCACACAGTATTCCACGGGGCAAGTCAGCGTGGAGATCGAGTGGGAGCTG CAGAAGGAGAACAGCAAACGCTGGAACCCCGAGATCCAGTACACTTCCAACTACAACAAG TCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATT GGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTGTAATTC GTTTCAGTTGAACTTTGGTCTCCGCGTACTTCTTTTTCTTATCTAGTTTCCATGGCTACG TAGATAAGTAGCATGGCGGGTGAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGG CCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGCGACCAAAGGTCGCCCGAC GCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCA A SEQ ID NO: 119 >#1055_AAV.FL.linear_Capsid sequence_ [organism = Adeno-associated virus] [mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] GGTATGGCTGCCGATGGTTATCTTCCAGATTGGCTCGAGGACACTCTCTCTGAAGGAATA AGACAGTGGTGGAAGCTCAAACCTGGCCCACCACCACCAAAGCCCGCAGAGCGGCATAAG GACGACAGCAGGGGTCTTGTGCTTCCTGGGTACAAGTACCTCGGACCCTTCAACGGACTC GACAAGGGAGAGCCGGTCAACGAGGCAGACGCCGCGGCCCTCGAGCACGACAAAGCCTAC GACCGGCAGCTCGACAGCGGAGACAACCCGTACCTCAAGTACAACCACGCCGACGCGGAG TTTCAGGAGCGCCTTAAAGAAGATACGTCTTTTGGGGGCAACCTCGGACGAGCAGTCTTC CAGGCGAAAAAGAGGGTTCTTGAACCTCTGGGCCTGGTTGAGGAACCTGTTAAGACGGCT CCGGGAAAAAAGAGGCCGGTAGAGCACTCTCCTGTGGAGCCAGACTCCTCCTCGGGAACC GGAAAGGCGGGCCAGCAGCCTGCAAGAAAAAGATTGAATTTTGGTCAGACTGGACCTTAT GCTTCCGTACCTGACCCCCAGCCTCTCGGACAGCCACCAGCAGCCCCCTCTGGTCTGGGA ACTAATACGATGGCTACAGGCAGTGGCGCACCAATGGCAGACAATAACGAGGGCGCCGAC GGAGTGGGTAATTCCTCGGGAAATTGGCATTGCGATTCCACATGGATGGGCGACAGAGTC ATCACCACCAGCACCCGCACCTGGGCTCTGCCCACCTACAACAACCATCTGTACAAGCAG ATTTCCAGCCAGTCTGGAGCCAGCAACGACAACCACTACTTTGGCTACAGCACCCCCTGG GGGTATTTTGACTTCAACAGATTCCACTGCCACTTTTCGCCACGCGACTGGCAGAGACTC ATCAACAACAACTGGGGATTCCGGCCCAAAAGACTCAACTTCAAGCTGTTTAACATTCAA GTCAAGGAGGTCACGCAGAATGACGGTACGACGACGATTGCCAATAACCTTACCAGCACG GTTCAGGTGTTTACTGACTCGGAGTACCAGCTCCCGTACGTCCTCGGCTCGGCGCATCAA GGATGCCTCCCGCCGTTCCCAGCAGACGTCTTCATGGTGCCACAGTATGGATACCTCACC CTGAACAACGGGAGTCAGGCGGTCGGACGCTCTTCCTTTTACTGCCTGGAGTACTTTCCT TCTCAGATGCTTCGTACAGGAAACAACTTTACCTTCAGCTACACCTTTGAAGACGTTCCT TTCCACAGCAGCTACGCTCACAGCCAGAGTCTGGACCGTCTCATGAATCCTCTCATCGAC CAGTACCTGTATTACTTGAGCAGAACAAACACGCCGAGCGGAACCACCACGCAGTCCAGG CTTCAGTTTTCTCAGGCCGGAGCGAGTGACATTCGGGACCAGTCTAGGAACTGGCTTCCT GGACCCTGTTACCGCCAGCAGCGAGTATCAAAGACAGCTGCGGATAACAACAACAGTGAA TACTCGTGGACTGGAGCTACCAAGTACCACCTCAATGGCAGAGACTCTTTGGTGAATCCG GGCCCGGCCATGGCCAGCCACAAGGACGATGAAGAAAAGTTTTTTCCTCAAAGCGGGGTT CTCATCTTTGGGAAGCAAGGCTCAGAGAAAACAAATGTGGACATTGAAAAGGTCATGATT ACAGACGAAGAGGAAATCAGGACCACCAATCCCGTGGCTACGGAGCAGTATGGTGCTGTA TCTACCAACCTCCAGAGCGGCAACACACAAGCAGCTACCTCAGATGTCAACACACAAGGC GTTCTTCCAGGCATGGTCTGGCAGGACAGAGACGTGTACCTGCAGGGGCCCATCTGGGCA AAGATTCCACACACGGACGGACATTTTCACCCCTCTCCCCTCATGGGCGGATTTGGACTG AAGCACCCTCCTCCACAGATTCTCATTAAGAATACCCCAGTACCTGCGAATCCTTCTACC ACTTTCAGCGCGGCAAAGTTTGCTTCCTTCATCACACAGTATTCCACGGGGCAGGTCAGC GTGGAGATCGAATGGGAGCTGCAAAAGGAGAACAGCAAACGCTGGAATCCCGAAATTCAG TACACTTCAAACTACAACAAATCTGTTAATGTGGACTTTACTGTGGACACTAATGGTGTG TATTCAGAGCCTCGCCCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTT AATCAATAAACCGTGTAATTCGTTTCAGTTGAACTTTGGTCTCTGCGTACTTCTTTCTTA TCTAGTTTCCATGGCTACGTAGATAAGTAGCATGGCGGGTTAATCATTAACACAAGGAAC CCCTAGTGATGGAGTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGC GACCAAAGGTCGCCCGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGC GCAGAGAGGGAGTGGCCAA SEQ ID NO: 120 >#M258_AAV.FL.linear_Capsid sequence_ [organism = Adeno-associated virus] [mol_type = genomic DNA][isolation_source = liver tissue][topology = linear] TTTAAATCAGGTATGGCTGCCGATGGTTATCTTCCAGATTGGCTCGAGGACACTCTCTCT GAAGGAATAAGACAGTGGTGGAAGCTCAAACCTGGCCCACCACCGCCAAAGCCCGCAGAG CGGCATAAGGACGACAGCAGGGGTCTTGTGCTTCCTGGGTACAAGTACCTCGGACCCTTC AACGGACTCGACAAGGGAGAGCCGGTCAACGAGGCAGACGCCGCGGCCCTCGAGCACGAC AAGGCCTACGACCGGCAGCTCGACAGCGGAGACAACCCGTACCTCAAGTACAACCACGCC GACGCGGAGTTTCAGGAGCGCCTTAAAGAAGATACGTCTTTTGGGGGCAACCTCGGACGA GCAGTCTTCCAGGCAAAAAAGAGGGTTCTTGAACCTCTGGGCCTGGTTGAGGAGCCTGTT AAGACGGCTCCGGGAAAAAAGAGGCCGGTAGAGCACTCTCCTGCGGAGCCAGACTCCTCC TCGGGAACCGGAAAAGCGGGCAACCAGCCTGCAAGAAAAAGATTGAATTTCGGTCAGACT GGAGACGCAGACTCCGTACCTGACCCCCAGCCTCTCGGAGAACCACCAGCAGCCCCCACA AGTTTGGGATCTACTACAATGGCTTCAGGCGGTGGCGCACCAGTGGCAGACAATAACGAG GGTGCCGATGGAGTGGGTAATTCCTCGGGGAAATTGGCATTGCGATTCCCAATGGCTGGG CGACAGAGTCATTACCACCAGCACCCGAACCTGGGCCCTGCCCACCTACAACAACCATCT GTACAAGCAAATTTCCAGCCAATCAGGAGCCAGCAACGACAACCACTAATCTTGGCTCAC TGCAACCCCTGGGGGTATTTTGACTTCAACAGATTCCACTGCCACTTTTCACCACGTGAC TGGCAAAGACTCATCAACAACAACTGGGGATTCCGGCCCAAAAGACTCAACTTCAAGCTC TTTAACATTCAAGTCAAAGAGGTCACGCAGAATGACGGTACGACGACGATTGCCAATAAC CTTACCAGCACGGTTCAGGTGTTTACTGACTCGGAGTACCAGATCCCGTACGTCCTCGGC TCGGCGCATCAAGGATGCCTCCCGCCGTTCCCAGCAGACGTCTTCATGGTGCCACAGTAT GGATACCTCACCCTGAACAACGGGAGTCAGGCGGTAGGACGCTCTTCCTTTTACTGCTTG GAGTACTTTCCTTCTCAGATGCTGCGTACTGGAAACAACTTCCAATTCAGCTACACCTTT GAAGACGTTCCTTTCCACAGCAGCTACGCTCACAGCCAGAGTCTGGATCGGCTGATGAAT CCTCTGATCGACCAGTACCTGTATTATCTGAACAAGACACAATCAGCCAGTGGAACTGTT CAGCAGTCTCGGCTACTGTTTAGCCAAGCTGGACCCACCAGCATGTCTCTTCAAGCTAAA AACTGGCTGCCTGGACCTTGCTACAGACAGCAGCGTCTGTCAAAGCAGGCAAACGAAAAC AACAACAGCAACTTTCCCTGGACTGCGGCTACAAAGTATCATCTCAATGGCCGGGACTCG TTGGTTAATCCAGGACCAGCTATGGCCAGTCACAAGGATGACGAAGAAAAGTTTTTCCCC ATGCATGGAACCCTGATATTTGGTAAACAAGGAACTGGAAGAGACAACGCGGATTTGGAC AATGTCATGATTACAGATGAAGAAGAAATCCGCACCACCAATCCCGTGGCTACGGAGCAG TACGGATATGTGTCAAATAATTTGCAAAACTCAAACACTGCTCCGAGTACTGGAACTGTC AATCACCAAGGAGCGTTACCTGGTATGGTGTGGCAGGATAGAGACGTGTACCTGCAGGGA CCCATTTGGGCCAAGATTCCTCACACCGATGGACACTTTCATCCTTCTCCGCTGATGGGA GGTTTTGGACTCAAACACCCACCTCCTCAGATCATGATCAAAAACACTCCCGTTCCAGCC AATCCTCCTACAAACTTCAGTGCGGCAAAATTTGCTTCCTTTATCACACAGTATTCCACG GGACAGGTCAGCGTGGAGATCGAGTGGGAGCTGCAGAAGGAGAACAGCAAACGCTGGAAC CCCGAGATCCAGTACACTTCCAACTACAACAAGTCTGTTAATGTGGACTTTACTGTGGAC ACTAATGGTGTGTATTCAGAGCCTCGCCCCATTGGCACCAGATACCTGACTCGTAATCTG TAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTTGAACTTTGGTCTCTGCGT ACTTCTTTTCTTATCTAGTTTCCATGGCTACGTAGATAAGTAGCATGGCGGGTTAATCAT TAACTCTAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCTCTGCGCGCTCGCYMSCY SMCTSWGSCYSKSAAA SEQ ID NO: 122 >>consensus AAV2 atggctgccgatggttatcttccagattggctcgaggacactctctctgaaggaataagacagtggtggaagct caaacctggcccaccaccaccaaagcccgcagagcggcataaggacgacagcaggggtcttgtgcttcctgggt acaagtacctcggacccttcaacggactcgacaagggagagccggtcaacgaggcagacgccgcggccctcgag cacgacaaggcctacgaccggcagctcgacagcggagacaacccgtacctcaagtacaaccacgccgacgcgga gtttcaggagcgccttaaagaagatacgtcttttgggggcaacctcggacgagcagtcttccaggcgaaaaaga gggttcttgaacctctgggcctggttgaggaacctgttaagacggctccgggaaaaaagaggccggtagagcac tctcctgcggagccagactcctcctcgggaaccggaaaagcgggccaccagcctgcaagaaaaagattgaattt cggtcagactggagacgcagactccgtacctgacccccagcctctcggacagccaccagcagccccctctggtc tgggaactaatacgatggctacaggcagtggcgcaccaatggcagacaataacgagggcgccgacggagtgggt aattcctcgggaaattggcattgcgattccacatggatgggcgacagagtcatcaccaccagcacccgaacctg ggctctgcccacctacaacaaccatctgtacaagcagatttccagccaatcaggagcctcaaacgacaaccact actttggctacagcaccccctgggggtattttgacttcaacagattccactgccacttttcaccacgtgactgg caaagactcatcaacaacaactggggattccgacccaagagactcaacttcaagctctttaacattcaagtcaa agaggtcacgcagaatgacggtacgacgacgattgccaataaccttaccagcacggttcaggtgtttactgact cggagtaccagctcccgtacgtcctcggctcggcgcatcaaggatgcctcccgccgttcccagcagacgtcttc atggtgccacagtatggatacctcaccctgaacaacgggagtcaggcagtaggacgctcttcattttactgcct ggagtactttccttctcagatgctgcgtaccggaaacaactttaccttcagctacacctttgaggacgttcctt tccacagcagctacgctcacagccagagtttggaccgtctcatgaatcctctcatcgaccagtacctgtattac ttgagcagaacaaacactccaagcggaaccaccacgcagtccaggcttcagttttctcaggccggagcgagtga cattcgggaccagtctaggaactggcttcctggaccctgttaccgccagcagcgagtatcaaagacagctgcgg ataacaacaacagtgaatactcgtggactggagctaccaagtaccacctcaatggcagagactctctggtgaat ccgggcccggccatggccagccacaaggacgatgaagaaaagttttttcctcagagcggggttctcatctttgg gaagcaaggctcagagaaaacaaatgtggacattgaaaaggtcatgattacagacgaagaggaaatcaggacca ccaatcccgtggctacggagcagtatggttctgtatctaccaacctccagagcggcaacacacaagcagctacc tcagatgtcaacacacaaggcgttcttccaggcatggtctggcaggacagagacgtgtacctgcaggggcccat ctgggcaaagattccacacacggacggacattttcacccctctcccctcatgggcggatttggacttaaacacc ctcctccgcagattctcatcaagaacaccccggtacctgcgaatccttcgaccaccttcagtgcggcaaagttt gcttccttcatcacacagtactccacggggcaggtcagcgtggagatcgagtgggagctgcagaaggagaacag caaacgctggaatcccgagatccagtacacttccaactacaacaaatctgttaatgtggactttactgtggaca ctaatggtgtgtattcagagcctcgccccattggcaccagatacctgactcgtaatctgtaa

AAV Comprising a Capsid Protein of the Present Invention:

A further object of the present invention relates to an adeno-associated virus (AAV) that comprises at least one capsid protein of the present invention.

In some embodiments, the AAV is a wildtype AAV. In some embodiments, the AAV comprises a genome sequence as set forth in SEQ ID NO: 62-120.

A further object of the present invention relates to an AAV wherein the amino acid sequence of VP1 capsid protein is encoded by the nucleotides 2203-4410 of in SEQ ID NO: 85 (i.e. capsid #3013), SEQ ID NO: 68 (i.e. capsid #2087), SEQ ID NO: 79 (i.e. capsid #1449), SEQ ID NO: 69 (i.e. capsid #2206), SEQ ID NO: 71 (i.e. capsid #1534), SEQ ID NO: 115 (i.e. capsid #163), SEQ ID NO: 82 (i.e. capsid #1343), SEQ ID NO: 112 (i.e. capsid #790), SEQ ID NO:65 (i.e. capsid #1017), SEQ ID NO: 70 (i.e. capsid #877), SEQ ID NO: 67 (i.e. capsid #1273), SEQ ID NO: 62 (i.e. capsid #2497); SEQ ID NO: 119 (i.e. capsid #1055); SEQ ID NO: 73 (i.e. capsid #1919), SEQ ID NO:63, SEQ ID NO:64; SEQ ID NO:66, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO:98, SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:103, SEQ ID NO:104; SEQ ID NO:105, SEQ ID NO: 106; SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO: 110; SEQ ID NO:111, SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO:116, SEQ ID NO: 117; SEQ ID NO:118 or SEQ ID NO:120; or, the amino acid sequence of VP2 capsid protein is encoded by nucleotides 2614-4410 of in SEQ ID NO: 85 (i.e. capsid #3013), SEQ ID NO: 68 (i.e. capsid #2087), SEQ ID NO: 79 (i.e. capsid #1449), SEQ ID NO: 69 (i.e. capsid #2206), SEQ ID NO: 71 (i.e. capsid #1534), SEQ ID NO: 115 (i.e. capsid #163), SEQ ID NO: 82 (i.e. capsid #1343), SEQ ID NO: 112 (i.e. capsid #790), SEQ ID NO:65 (i.e. capsid #1017), SEQ ID NO: 70 (i.e. capsid #877), SEQ ID NO: 67 (i.e. capsid #1273), SEQ ID NO: 62 (i.e. capsid #2497); SEQ ID NO: 119 (i.e. capsid #1055); SEQ ID NO: 73 (i.e. capsid #1919), SEQ ID NO:63, SEQ ID NO:64; SEQ ID NO:66, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO:98, SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:103, SEQ ID NO:104; SEQ ID NO:105, SEQ ID NO: 106; SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO: 110; SEQ ID NO:111, SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO:116, SEQ ID NO: 117; SEQ ID NO:118 or SEQ ID NO:120 and the amino acid sequence of VP3 capsid protein is encoded by nucleotides 2809-4410 of in SEQ ID NO: 85 (i.e. capsid #3013), SEQ ID NO: 68 (i.e. capsid #2087), SEQ ID NO: 79 (i.e. capsid #1449), SEQ ID NO: 69 (i.e. capsid #2206), SEQ ID NO: 71 (i.e. capsid #1534), SEQ ID NO: 115 (i.e. capsid #163), SEQ ID NO: 82 (i.e. capsid #1343), SEQ ID NO: 112 (i.e. capsid #790), SEQ ID NO:65 (i.e. capsid #1017), SEQ ID NO: 70 (i.e. capsid #877), SEQ ID NO: 67 (i.e. capsid #1273), SEQ ID NO: 62 (i.e. capsid #2497); SEQ ID NO: 119 (i.e. capsid #1055); SEQ ID NO: 73 (i.e. capsid #1919), SEQ ID NO:63, SEQ ID NO:64; SEQ ID NO:66, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:87; SEQ ID NO:88; SEQ ID NO:89; SEQ ID NO:90; SEQ ID NO: 91; SEQ ID NO:92; SEQ ID NO:93; SEQ ID NO:94; SEQ ID NO:95; SEQ ID NO:96; SEQ ID NO:97; SEQ ID NO:98, SEQ ID NO: 99; SEQ ID NO:100; SEQ ID NO:101; SEQ ID NO:102; SEQ ID NO:103, SEQ ID NO:104; SEQ ID NO:105, SEQ ID NO: 106; SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO: 110; SEQ ID NO:111, SEQ ID NO:113; SEQ ID NO:114; SEQ ID NO:116, SEQ ID NO: 117; SEQ ID NO:118 or SEQ ID NO:120.

In some embodiments, the AAV of the present invention is a rAAV that comprises a heterologous nucleic acid comprising a transgene.

In some embodiments, the transgene encodes for a therapeutic protein. The term “therapeutic protein” refers to a protein which is defective or missing from the subject in question, thus resulting in a disease state or disorder in the subject, or to a protein which confers a benefit to the subject in question, such as an antiviral, antibacterial or antitumor function. A therapeutic protein can also be one which modifies any one of a wide variety of biological functions, such as endocrine, immunological and metabolic functions. Typically, the transgene may encode for a polypeptide involved in immune response, hematopoiesis, inflammation, cell growth and proliferation, cell lineage differentiation, or stress response.

In some embodiments, the transgene encodes for a site-specific endonuclease that provides for site-specific knock-down of gene function, e.g., where the endonuclease knocks out an allele associated with a disease. For example, where a dominant allele encodes a defective copy of a gene that, a site-specific endonuclease can be targeted to the defective allele and knock out the defective allele. In some embodiments, the rAAV of the present invention comprises a polynucleotide that encodes a site-specific endonuclease; and a polynucleotide that encodes a functional copy of a defective allele, where the functional copy encodes a functional protein. Site-specific endonucleases that are suitable for use include, e.g., zinc finger nucleases (ZFNs); transcription activator-like effector nucleases (TALENs), and CRISPR-associated endonuclease. As used herein, the term “CRISPR-associated endonuclease” has its general meaning in the art and refers to clustered regularly interspaced short palindromic repeats associated which are the segments of prokaryotic DNA containing short repetitions of base sequences. In particular, the CRISPR-associated endonuclease is Cas9 or a derivative thereof. The Cas9 nuclease can have a nucleotide sequence identical to the wild type Streptococcus pyrogenes sequence. Alternatively, the wild type Streptococcus pyrogenes Cas9 sequence can be modified. For instance, the Cas9 nuclease sequence can be for example, the sequence contained within a commercially available vector such as PX330 or PX260 from Addgene (Cambridge, Mass.). In some embodiments, the Cas9 endonuclease can have an amino acid sequence that is a variant or a fragment of any of the Cas9 endonuclease sequences of Genbank accession numbers KM099231.1 GL669193757; KM099232.1; GL669193761; or KM099233.1 GL669193765 or Cas9 amino acid sequence of PX330 or PX260 (Addgene, Cambridge, Mass.). The Cas9 nucleotide sequence can be modified to encode biologically active variants of Cas9, and these variants can have or can include, for example, an amino acid sequence that differs from a wild type Cas9 by virtue of containing one or more mutations (e.g., an addition, deletion, or substitution mutation or a combination of such mutations). For example the Cas9 nuclease can be mutated in the conserved FiNH and RuvC domains, which are involved in strand specific cleavage. For example, an aspartate-to-alanine (D10A) mutation in the RuvC catalytic domain allows the Cas9 nickase mutant (Cas9n) to nick rather than cleave DNA to yield single-stranded breaks, and the subsequent preferential repair through HDR can potentially decrease the frequency of unwanted indel mutations from off-target double-stranded breaks. In some embodiments, the rAAV of the present invention comprises one or more guide RNA. As used herein, the term “one or more guide RNA” refers to the RNAs that guide the insertion or deletion of residues. In the context of the invention, the guide RNA is used for recruiting Cas9 to specific genomic loci. In some embodiments, the guide RNA can be a sequence complementary to a coding or a non-coding sequence. In some embodiments, the subject is administered with a combination of at least one vectors comprising one polynucleotide encoding for a Cas9 endonuclease and at least one vector comprising the guide RNA.

In some embodiments, the transgene encodes for an interfering RNA (RNAi), in particular a siRNA. A “small interfering” or “short interfering RNA” or siRNA is a RNA duplex of nucleotides that is targeted to a gene interest (a “target gene”). An “RNA duplex” refers to the structure formed by the complementary pairing between two regions of a RNA molecule. siRNA is “targeted” to a gene in that the nucleotide sequence of the duplex portion of the siRNA is complementary to a nucleotide sequence of the targeted gene. In some embodiments, the length of the duplex of siRNAs is less than 30 nucleotides.

In some embodiments, the transgene encodes for an antisense oligonucleotide. As used herein, the term “antisense oligonucleotide” is understood to refer to a nucleotide sequence which is substantially complementary to a target nucleotide sequence in a pre-mRNA molecule, hnRNA (heterogenous nuclear RNA) or mRNA molecule. The degree of complementarity (or substantial complementarity) of the antisense sequence is preferably such that a molecule comprising the antisense sequence can form a stable hybrid with the target nucleotide sequence in the RNA molecule under physiological conditions.

Other transgenes of interest include, without limitation, synthetic long non-coding RNAs (SINEUPs; Carrieri et al., 2012, Nature 491: 454-7; Zucchelli et al., 2015, RNA Biol 12(8): 771-9; Indrieri et al., 2016, Sci Rep 6: 27315) and artificial microRNAs. Other specific transgene of interest useful in the practice of the present invention are described below.

In some embodiments, the transgene is operably linked to a constitutive promoter. In some embodiments the transgene is operably linked to an inducible promoter. In some embodiments, the transgene is operably linked to a tissue-specific or cell type-specific regulatory element.

Numerous methods are known in the art for production of rAAV vectors, including transfection, stable cell line production, and infectious hybrid virus production systems which include adenovirus-AAV hybrids, herpesvirus-AAV hybrids (Conway, J E et al., (1997) J. Virology 71(11):8780-8789) and baculovirus-AAV hybrids. rAAV production cultures for the production of rAAV virus particles all require; 1) suitable host cells, including, for example, human-derived cell lines such as HeLa, A549, or 293 cells, or insect-derived cell lines such as SF-9, in the case of baculovirus production systems; 2) suitable helper virus function, provided by wild-type or mutant adenovirus (such as temperature sensitive adenovirus), herpes virus, baculovirus, or a plasmid construct providing helper functions; 3) AAV rep and cap genes and gene products; 4) a transgene (such as a therapeutic transgene) flanked by at least one AAV ITR sequences; and 5) suitable media and media components to support rAAV production. Suitable media known in the art may be used for the production of rAAV vectors. These media include, without limitation, media produced by Hyclone Laboratories and JRH including Modified Eagle Medium (MEM), Dulbecco's Modified Eagle Medium (DMEM), custom formulations such as those described in U.S. Pat. No. 6,566,118, and Sf-900 II SFM media as described in U.S. Pat. No. 6,723,551, each of which is incorporated herein by reference in its entirety, particularly with respect to custom media formulations for use in production of recombinant AAV vectors. The rAAV particles can be produced using methods known in the art. See, e.g., U.S. Pat. Nos. 6,566,118; 6,989,264; and 6,995,006. In practicing the invention, host cells for producing rAAV particles include mammalian cells, insect cells, plant cells, microorganisms and yeast. Host cells can also be packaging cells in which the AAV rep and cap genes are stably maintained in the host cell or producer cells in which the AAV vector genome is stably maintained. Exemplary packaging and producer cells are derived from 293, A549 or HeLa cells. AAV vectors are purified and formulated using standard techniques known in the art.

In some embodiments, rAAV particles may be produced by a triple transfection method, such as the exemplary triple transfection method provided infra. Briefly, a plasmid containing a rep gene and a capsid gene, along with a helper adenoviral plasmid, may be transfected (e.g., using the calcium phosphate method) into a cell line (e.g., HEK-293 cells), and virus may be collected and optionally purified.

In some embodiments, rAAV particles may be produced by a producer cell line method, such as the exemplary producer cell line method provided infra (see also (referenced in Martin et al., (2013) Human Gene Therapy Methods 24:253-269). Briefly, a cell line (e.g., a HeLa cell line) may be stably transfected with a plasmid containing a rep gene, a capsid gene, and a promoter-transgene sequence. Cell lines may be screened to select a lead clone for rAAV production, which may then be expanded to a production bioreactor and infected with an adenovirus (e.g., a wild-type adenovirus) as helper to initiate rAAV production. Virus may subsequently be harvested, adenovirus may be inactivated (e.g., by heat) and/or removed, and the rAAV particles may be purified.

In some embodiments, a method is provided for producing any rAAV particle as disclosed herein comprising (a) culturing a host cell under a condition that rAAV particles are produced, wherein the host cell comprises (i) one or more AAV package genes, wherein each said AAV packaging gene encodes an AAV replication and/or encapsidation protein; (ii) a rAAV pro-vector comprising a transgene flanked by at least one AAV ITR, and (iii) an AAV helper function; and (b) recovering the rAAV particles produced by the host cell. rAAV vector particles of the invention may be harvested from rAAV production cultures by lysis of the host cells of the production culture or by harvest of the spent media from the production culture, provided the cells are cultured under conditions known in the art to cause release of rAAV particles into the media from intact cells, as described more fully in U.S. Pat. No. 6,566,118). Suitable methods of lysing cells are also known in the art and include for example multiple freeze/thaw cycles, sonication, microfluidization, and treatment with chemicals, such as detergents and/or proteases.

In some embodiments, the rAAV particles are purified. The term “purified” as used herein includes a preparation of rAAV particles devoid of at least some of the other components that may also be present where the rAAV particles naturally occur or are initially prepared from. Thus, for example, isolated rAAV particles may be prepared using a purification technique to enrich it from a source mixture, such as a culture lysate or production culture supernatant. Enrichment can be measured in a variety of ways, such as, for example, by the proportion of DNase-resistant particles (DRPs) or genome copies (gc) present in a solution, or by infectivity, or it can be measured in relation to a second, potentially interfering substance present in the source mixture, such as contaminants, including production culture contaminants or in-process contaminants, including helper virus, media components, and the like. rAAV particles may be isolated or purified using one or more of the following purification steps: equilibrium centrifugation; flow-through anionic exchange filtration; tangential flow filtration (TFF) for concentrating the rAAV particles; rAAV capture by apatite chromatography; heat inactivation of helper virus; rAAV capture by hydrophobic interaction chromatography; buffer exchange by size exclusion chromatography (SEC); nanofiltration; and rAAV capture by anionic exchange chromatography, cationic exchange chromatography, or affinity chromatography. These steps may be used alone, in various combinations, or in different orders. In some embodiments, the method comprises all the steps in the order as described below. Methods to purify rAAV particles are found, for example, in Xiao et al., (1998) Journal of Virology 72:2224-2232; U.S. Pat. Nos. 6,989,264 and 8,137,948; and WO 2010/148143.

Therapeutic Uses and Pharmaceutical Compositions:

The rAAV of the present invention are particularly suitable for delivering the transgene to a cell of interest. Accordingly, a further object of the present invention relates to a method of delivering a transgene to a cell comprising contacting the cell with an amount of a rAAV of the present invention.

In particular, the rAAV of the present invention are particularly suitable for gene therapy. Gene therapy consists in introducing in tissue of interest a functional copy of a transgene (e.g. a gene) that is deficient therein (gene replacement therapy), or by delivering to the tissue a transgene which will have a beneficial effect on the disease to be treated (symptomatic therapy). In some embodiments, the rAAV of the present invention is particularly suitable for delivering a transgene in liver.

Thus a further object of the present invention relates to a method for delivering a transgene to a tissue in a subject, the method comprising administering to the subject: an effective amount of a rAAV of the present invention.

More specifically, the present invention provides a method of therapy in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a rAAV of the present invention.

A further object of the present invention relates to a pharmaceutical composition comprising the rAAV of the present invention with pharmaceutically acceptable excipients, and optionally sustained-release matrices, such as biodegradable polymers. The pharmaceutical composition of the present invention thus comprises a pharmaceutically acceptable excipient, carrier, buffer, stabiliser or other materials well known to those skilled in the art. A pharmaceutically acceptable carrier or excipient refers to a non-toxic solid, semi-solid or liquid filler, diluent, encapsulating material or formulation auxiliary of any type. Such materials should be non-toxic and should not interfere with the efficacy of the active ingredient (i.e. the rAAV of the present invention of the invention). The precise nature of the carrier or other material may be determined by the skilled person according to the route of administration, i.e. here subretinal injection. The pharmaceutical composition is typically in liquid form. Liquid pharmaceutical compositions generally include a liquid carrier such as water, petroleum, animal or vegetable oils, mineral oil or synthetic oil. Physiological saline solution, magnesium chloride, dextrose or other saccharide solution or glycols such as ethylene glycol, propylene glycol or polyethylene glycol may be included. For injection, the active ingredient will be in the form of an aqueous solution, which is pyrogen-free and has suitable pH, isotonicity and stability. Those of relevant skill in the art are well able to prepare suitable solutions using, for example, isotonic vehicles such as Sodium Chloride Injection, Ringer's Injection, Lactated Ringer's Injection. Preservatives, stabilisers, buffers, antioxidants and/or other additives may be included, as required. For delayed release, the rAAV of the present invention may be included in a pharmaceutical composition, which is formulated for slow release, such as in microcapsules formed from biocompatible polymers or in liposomal carrier systems according to methods known in the art. Typically, the pharmaceutical composition of the present invention is supplied in a prefilled syringe. A “ready-to-use syringe” or “prefilled syringe” is a syringe which is supplied in a filled state, i.e. the pharmaceutical composition to be administered is already present in the syringe and ready for administration. Prefilled syringes have many benefits compared to separately provided syringe and vial, such as improved convenience, affordability, accuracy, sterility, and safety. The use of prefilled syringes results in greater dose precision, in a reduction of the potential for needle sticks injuries that can occur while drawing medication from vials, in pre-measured dosage reducing dosing errors due to the need to reconstituting and/or drawing medication into a syringe, and in less overfilling of the syringe helping to reduce costs by minimising drug waste. In some embodiments the pH of the liquid pharmaceutical composition of the present invention is in the range of 5.0 to 7.0, 5.1 to 6.9, 5.2 to 6.8, 5.3 to 6.7 or 5.4 to 6.6.

The invention will be further illustrated by the following figures and examples. However, these examples and figures should not be interpreted in any way as limiting the scope of the present invention.

FIGURES

FIG. 1. AAV Full-length sequences in 57 human liver tissues. A) Location of the two open reading frames encoding replication proteins (Rep78, Rep68, Rep52 and Rep40), structural proteins (VP1, VP2 and VP3) and AAP protein coding by AAV genome. Promoters (p5, p19 and p40) are indicated with arrows. B) Amino acid variations compared to the reference AAV2 are indicated. The triangles indicate genome location of specific AAV2/13 (top) or AAV2 (middle) variants in the series of 57 human liver AAV isolates. Common variants shared by both genotypes are shown (bottom). Grey and black colors refer to silent and missense AAV variants, respectively; numbers correspond to wild-type AAV2 nucleotide sequence coordinates (NC_001401).

FIG. 2. All new capsids detarget the liver in this mouse model

Luciferase activity of controls and new capsids capsids. Each column represents the average of activity in at least 3 mice expressed as fold change versus AAV2. Standard deviations are displayed. On the right, the phylogenetic tree of the VP1 amino acid sequences was constructed using the Neighbor-Joining method. The evolutionary distances were computed using the Poisson correction method and are in the units of the number of amino acid substitutions per site.

FIG. 3. The new capsids efficiently target the muscles

A-C). Luciferase activity of controls and new capsids. Each column represents the average of activity in at least 3 mice expressed as fold change versus AAV2. Standard deviations are displayed. Statistical analysis on fold change was performed using one-way ANOVA. Dunnett's multiple comparison test was used to compare the mean of each capsid with the mean of the controls (* versus PBS, # versus AAV2 and $ versus AAV*). *, #, $=p<0.05; **, ##, $$=p<0.01; ***, ###, $$$=p<0.001.

EXAMPLE 1: ADENO-ASSOCIATED VIRUS IN THE LIVER: NATURAL HISTORY

Results:

Identification of Two Major AAV Genotypes in the Liver

We screened frozen liver tissues from 1,319 patients for the presence of AAV viral DNA with 6 Taqman probes distributed along the genome that collectively recognize all known AAV genotypes 1 to 13. We identified AAV DNA in 18% of non-tumor liver tissues (n=233), 82 of which were further analyzed by viral capture with 120-mer oligonucleotide probes covering the entire genome of all known AAV genotypes (350 probes/genotype). After sequencing, a complete coverage of the viral genome was obtained in 57 samples, which allowed to reconstruct full-length AAV sequences (FIG. 1A). These sequences revealed two major AAV subtypes. The first subtype (n=25) is highly similar to AAV2 reference sequence (NC_001401) also corresponding to VP1 Clade B genotype isolated in human^(14, 43) (data not shown). The second subtype (n=32), here named AAV2/13, showed hybrid sequences including various parts of the AAV13 capsid and c-ter in the context of an AAV2 5′part (FIG. 1B). VP1 sequences of this subtype corresponded to various pieces of AAV13 and were previously termed Clade C (data not shown).^(14, 43) We identified several variants shared by both AAV subtypes, but different from the AAV2 reference NC_001401, corresponding mostly to positions common in AAV2, AAV3 or AAV13, silent at the protein level (n=42, 87.5%) and distributed along the viral genome (FIG. 1B). In contrast, several nucleotide variants leading to amino acid substitutions in AAV2/13 sequences were located in the hypervariable regions (HVRs) 5, 6 7 and 10 and originated from AAV13 sequence (FIG. 1B). By screening the overall series of 1,319 samples with two probes specific of AAV2/13 subtype and located in the CAP2 region (data not shown), we determined the AAV genotype in 143 samples and identified an equal number of the two AAV subtypes (47.6% AAV2 and 52.4% AAV2/13 genotypes).

AAV Infection and Episomal Form

In the 233 liver samples positive for AAV DNA, quantification of AAV followed a bimodal distribution with 97% of the tissues showing a low number of copy/cell (ranging from 4.6e-05 to 0.04) and only 8 patients with higher quantity of AAV ranging from 0.07 to 0.18 copy/cell (data not shown). Relationship between AAV detection, clinical and histological features of the patients showed that AAV was significantly enriched in female (p<0.001), young patients (p=0.016) and occurred more frequently in a background of non-fibrotic liver (p<0.001; data not shown).

In 64/233 (27.5%) of the tissues positive for AAV, all the genomic AAV regions were amplified suggesting the presence of the entire viral genome. In order to experimentally search for episomal AAV form, we designed a DNAse/TaqMan based assay (data not shown) which allowed to detected episomal AAV in 60 patients, corresponding to 26% of AAV positive samples and 4.5% of all patients. Using in silico analyses of the AAV capture sequencing, among the 57 cases with a complete reconstructed AAV genomic sequence, we identified 14 cases with 3′ITR-5′ITR junctions without clonal insertion. The 3′ITR-5′ITR junctions showed various sequences presenting a double-D ITR structure, in flip or flop configuration, with a 125 bp deletion confirmed by Sanger sequencing (data not shown).

AAV Transcription is Associated with Episomal Form

Then, we screened for AAV RNA expression in 101 non-tumor liver tissues positive for AAV by qRT-PCR. AAV transcript was identified in 64% of the tested liver tissues. We showed that either AAV REP or CAP expression were enriched in liver tissues with episomal form (p<0.001) and both transcripts were more frequently associated in presence of episomal than not-episomal AAV form (p=0.022), defining a population of patients with an “episomal-expressed AAV” (data not shown). A higher AAV copies per cell was identified in liver tissues with episomal-expressed AAV, supporting the hypothesis of a viral active infection in these liver samples (data not shown). Episomal AAV were also more frequent in female (p<0.001) and non-cirrhotic patients (p<0.001; data not shown). Analysis of AAV positivity in function of age showed a peak of frequency at 25% in the 30-40 years class. AAV episomal form was more frequent in young patients (<40 years old) reaching the highest frequency level in the twenties (data not shown). These results suggest that AAV active infection is more frequent in the second and third decade during life, while inactive not-episomal forms subsist after the primary infection.

Discussion:

In this study, we provided a comprehensive description at large scale of wild type AAV infection in the liver and of its oncogenic consequences in human. Despite the large number of studies available on recombinant AAV vectors (rAAV), the natural history of wild type AAV infection is still poorly understood. Here, we provided an extensive characterization of the different AAV viral forms in the largest series of tumor and non-tumor liver tissues to better understand the AAV infection in human.

The prevalence of AAV was observed in 21% of patients in non-tumor and/or tumor liver in agreement with the seroprevalence of antibody against AAV identified in 40 to 80% of the general population.¹⁰⁻¹² Our result showed that half of the patients demonstrate persistent AAV DNA in the liver during life, mainly in the population of young and female patients without liver fibrosis. However, since most of our liver tissues were sampled from patients with liver diseases, the exact prevalence of AAV DNA in the liver of healthy individuals remains to be evaluated.

Two major AAV genotypes, AAV2 and hybrids AAV2/13, were identified in our cohort. The classification of AAV viruses is currently based on their serological response and on the amino acid sequence of the VP1 region defined by Gao and colleagues.¹⁴ However, this classification in viral clades does not include all the AAV serotypes and the most recently isolated viral clones from non-human primates.^(16, 46) Moreover, most of the sequences isolated from human tissues were restricted to VP1 region, in particular only one full-length AAV sequence from clade C was publicly available.⁴³ Here, we provided the whole AAV genome sequences of 57 human clones classified with half of them belonging to the reference AAV2 sequence, whereas the others were hybrids between AAV2 in the 5′part and AAV13 in the 3′ corresponding to the previous clade C of the VP1 classification. Our work dramatically increased the number human AAV full-length sequences publicly available enlightening the genotypes and genomic variants associated with an efficient natural AAV infection of the liver.

In conclusion, these findings are important to understand wild type AAV biology. Our data are particularly relevant considering the large usage of AAV vector in liver-targeted gene therapy.

EXAMPLE 2: PRODUCTION, IN VITRO AND IN VIVO TESTING OF NATURAL VARIANTS IDENTIFIED

Material and Methods

Plasmid Construction for New Serotypes

To construct the plasmid containing AAV2 Rep sequence and the new Cap genes, the capsid sequences were synthesized (GENEWIZ). The fragment was inserted in the plasmid pAAV2 which contains AAV2 Rep and AAV2 Cap in order to replace the AAV2 Cap with the corresponding new Cap sequence.

AAV Production

HEK293T cells were grown in suspension in 50 mL of serum-free medium. The cells were transfected with 3 plasmids: i) a transgene plasmid, containing AAV2 ITRs flanking an expression cassette ii) the helper plasmid pXX6, containing adenoviral sequences necessary for AAV production, and iii) a plasmid containing AAV Rep and Cap genes, defining the serotype of AAV. Two days after transfection, the cells were lysed to release the AAV particles.

The viral lysate was purified by affinity chromatography. Viral genomes were quantified by a TaqMan real-time PCR assay using primers and probes corresponding to the ITRs of the AAV vector genome (Rohr et al., J. Virol. Methods, 2002, 106, 81-88).

In Vivo Studies

All mouse studies were performed according to the French and European legislation on animal care and experimentation (2010/63/EU) and approved by the local institutional ethical committee (protocol no. 2016-002C). AAV vectors were administered intravenously via the tail vein to 6 weeks old male C57B16/J mice. PBS-injected littermates were used as controls. 15 days after vector injections, tissues were harvested and homogenized in DNAse/RNAse free water using Fastprep tubes (6.5 m/s; 60 seconds).

Luciferase Activity

Luciferase assay was used to measure the expression of the reporter gene used as transgene. Tissue lysates were centrifuged at 10000 rpm for 10 min, the supernatant was diluted in lysis buffer in a white opaque 96-well plate. Luciferase activity was measured using EnSpire (PerkinElmer) through sequential injections of assay buffer containing ATP and luciferine.

Protein quantification was performed on the samples using BCA assay in order to normalize the RLU (relative luminescence unit) on the quantity protein. The final results were expressed as RLU/mg of protein and normalized as fold change versus AAV2 control.

Results:

Recombinant AAV vectors were produced by cloning the Cap genes identified in EXAMPLE 1 in a plasmid suitable for vector production. A transgene expression cassette flanked by AAV2 ITRs and expressing a luciferase reporter gene was encapsidated in the so derived AAV vectors. Triple transfection of HEK293 cells was used to produce the vectors followed by immunoaffinity column purification. The capsid sequences that were not efficiently produced as rAAV vectors were excluded. The vectors were tested in wild-type C57Bl6/J mice through intravenous injection of the different vectors at the dose of 1×10¹¹ vg/mice. Fifteen days post-injection, animals were sacrificed and the levels of expression of the transgene were measured in isolated tissues. All new capsids detargeted the liver (FIG. 2) and displayed a marked tropism for the tested tissues: heart, quadriceps and diaphragm. The average fold change of transgene expression in the three tissues tested was used to rank the capsids according to their efficiency. The capsids represented in FIG. 3A-3C are the top scoring in muscle targeting.

REFERENCES

Throughout this application, various references describe the state of the art to which this invention pertains. The disclosures of these references are hereby incorporated by reference into the present disclosure.

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1-45. (canceled)
 46. A variant VP1 capsid protein that consists of the amino acid sequence as set forth in SEQ ID NO: 2 comprising at least one mutation selected from Table 1; or a derived variant VP2 or variant VP3 capsid protein.
 47. A polynucleotide that encodes for a variant capsid protein according to claim
 46. 48. An adeno-associated virus (AAV) that comprises at least one capsid protein according to claim 46, in particular a rAAV further comprising a heterologous nucleic acid comprising a transgene.
 49. A method of delivering a transgene to a cell comprising contacting the cell with an amount of a rAAV comprising at least one capsid protein according to claim 46 and a heterologous nucleic acid comprising a transgene.
 50. A method of therapy in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a rAAV comprising at least one capsid protein according to claim 46 and a heterologous nucleic acid comprising a transgene.
 51. A pharmaceutical composition comprising a rAAV comprising at least one capsid protein according to claim 46 and a heterologous nucleic acid comprising a transgene, with pharmaceutically acceptable excipients, and optionally sustained-release matrices, such as biodegradable polymers.
 52. A variant VP1 capsid protein that has an amino acid sequence selected from the group consisting of SEQ ID NO: 26 (capsid #3013), SEQ ID NO: 9 (capsid #2087), SEQ ID NO: 20 (capsid #1449), SEQ ID NO: 10 (capsid #2206), SEQ ID NO: 12 (capsid #1534), SEQ ID NO: 56 (capsid #163), SEQ ID NO: 23 (capsid #1343), SEQ ID NO: 53 (capsid #790), SEQ ID NO: 6 (capsid #1017), SEQ ID NO: 11 (capsid #877), SEQ ID NO: 8 (capsid #1273), SEQ ID NO: 3 (capsid #2497), SEQ ID NO: 60 (capsid #1055), SEQ ID NO: 14 (capsid #1919), SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 13, SEQ ID NO: 15 to SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 27 to SEQ ID NO: 55, SEQ ID NO: 57 to SEQ ID NO: 59, or SEQ ID NO: 61; or a derived variant VP2 or variant VP3 capsid protein.
 53. A variant VP1 capsid protein that consists of the amino acid sequence as set forth in SEQ ID NO:2 comprising at least one mutation selected from the group consisting of V151A, Q164N; T200S; N201T; M211V; T233Q; M235L; T410Q; S446N; R447K; N449Q; T450S; P451N; T455L; T456Q; Q461L; A467P; S468T; D469S; I470M; R471S; D472L; S474A; R475K; V488L; T491Q; S492A; A493N; E499N; Y500F; S501P; G504A; Q536M; S537H; V539T; S547T; E548N; K549A; T550N; N551D; V552A; I554L; E555D; K556N; S578Y; T581N; R585N; R585S; G586S; R588T; Q589G; A590P; A591T; A593S; A593G; D594T; T597H; V600A; L647M; S658P; T660N; and A663S; or a derived variant VP2 or variant VP3 capsid protein. 